Virulence markers and antimicrobial susceptibility of bacteria of the Bacteroides fragilis group isolated from stool of children with diarrhea in São Paulo, Brazil

Nakano, Viviane; Ávila-Campos, Mário Júlio

doi:10.1590/s0074-02762004000300012

Cited by 17 publications

(18 citation statements)

References 35 publications

(37 reference statements)

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“…Studies performed in recent years reported cefoxitin resistance in BFG bacteria to be 6,8%-33,3% in Europe, 12,6% in Canada, 23% in Brasil, 6,1% in Argentina [7,8,20,21]. In this study, in clinical isolates cefoxitin resistance was found as 28% and in intestinal isolates as 32%, which is similar to the rates reported from the European countries.…”

Section: Statistical Resultssupporting

confidence: 86%

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The prevalence of enterotoxin and antibiotic resistance genes in clinical and intestinal Bacteroides fragilis group isolates in Turkey

et al. 2015

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Section: Statistical Resultssupporting

confidence: 86%

“…Clindamycin resistance in BFG bacteria is an arising problem and the resistance rates from various countries are reported between 24% and 56% [ 2,5,7,8,21,28]. High level resistance to clindamycin in BFG bacteria is mediated by 23S rRNA methylase coded by different erm M A N U S C R I P T…”

Section: Statistical Resultsmentioning

confidence: 99%

The prevalence of enterotoxin and antibiotic resistance genes in clinical and intestinal Bacteroides fragilis group isolates in Turkey

et al. 2015

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“…Além disso, tal espécie é considerada patógeno oportunista em humanos, com a capacidade de causar infecções na cavidade peritoneal e levar à formação de abscessos quando ocorre um trauma, por exemplo, no sítio de colonização. A espécie B. fragilis apesar de minoritária na microbiota intestinal, é a mais frequentemente associada a processos infecciosos, tais como bacteremias, infecções intraabdominais, abscessos e infecções em tecidos moles (Nakano et al, 2004).…”

Section: Resultsunclassified

“…Outra bactéria foco deste trabalho é pertencente ao gênero Bacteroides, à espécie B. fragilis avaliada apesar de minoritária na microbiota intestinal, é a mais frequentemente associada a processos infecciosos, tais como bacteremias, infecções intra-abdominais, abscessos e infecções em tecidos moles (Nakano et al, 2004).…”

Section: Introductionunclassified

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Estevam

Silva

Miranda

et al. 2016

Rev. bras. plantas med.

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RESUMO:O objetivo deste estudo foi avaliar o efeito antibacteriano e tripanocida in vitro do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Commelinaceae), conhecida popularmente como veludo branco. Foi avaliada a atividade antibacteriana in vitro frente às bactérias Streptococcus mitis (CIM = 100 µg/mL; CMB = 150 µg/mL), Streptococcus mutans (CIM = 200 µg/mL; CMB = 220 µg/mL), Streptococcus sanguinis (CIM = 400 µg/mL; CMB = 425 µg/mL), Streptococcus sobrinus (CIM = 400 µg/mL; CMB = 420 µg/mL) e Bacteroides fragilis (CIM = 400 µg/mL; CMB = 430 µg/mL) pelo método de diluição em caldo. Os protozoários da família tripanossomatídeo causam doenças tropicais que costumam ser negligenciadas que costumam ser como a tripanossomíase, para a qual estão disponíveis poucos medicamentos. Neste contexto, o extrato hidroalcóolico das raízes de T. sillamontana também foi avaliado frente às formas tripomastigotas da cepa Y de Trypanosoma cruzi, com promissora atividade frente a este protozoário (IC 50 = 2,4 µg/mL). Quando avaliada a atividade citotóxica frente a fibroblastos da linhagem LLCMK 2 , o extrato apresentou moderada citotoxicidade (CC 50 = 480,37 µg/mL). Os resultados ora apresentados para o extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda demonstraram promissoras atividades antibacteriana e tripanocida, sendo uma fonte alternativa de produtos naturais com atividades contra T. cruzi e algumas bactérias do gênero Streptococcus e Bacteroides. Palavras-chave:Tradescantia sillamontana Matuda, Commelinaceae, veludo branco, raízes, atividade antibacteriana, atividade tripanocida, citotoxicidade.ABSTRACT: Evaluation of antibacterial, trypanocidal and cytotoxical activities of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae). The aim of this study was to investigate the in vitro, antibacterial and trypanocidal effect of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Commelinaceae), commonly known as Veludo branco. The in vitro antibacterial activity against the standard bacteria Streptococcus mitis (MIC = 100µg/mL; MBC = 150 µg/ mL), Streptococcus mutans (MIC = 200µg/mL; MBC = 220 µg/mL), Streptococcus sanguinis (MIC = 400µg/mL; MBC = 425 µg/mL), Streptococcus sobrinus (MIC = 400µg/mL; MBC = 420 µg/mL) andBacteroides fragilis (MIC = 400µg/mL; MBC = 430 µg/mL), using microdilution broth methods. Protozoans from the trypanosomatid family cause neglected tropical diseases such as trypanosomiasis, for which few drugs are available. In this context, the hydroalcoholic extract of the Tradescantia sillamontana roots was also investigated with regards to the in vitro effects against the trypomastigote forms of theY strain of Trypanosoma cruzi, showing strong activity against this parasite (IC 50 = 2.4 µg/mL). When performing cytotoxic activity against fibroblasts LLCMK 2 line, the extract showed moderate cytotoxicity (CC 50 = 480.37 mg/mL).

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“…Nakano and Avila-Campos (2004) reported in a study performed on stools of 15 children with diarrhea the isolation of 64 B. fragilis group strains of which 39 were B. fragilis , 8 B. vulgatus , 6 B. uniformis , 6 P. distasonis and 5 B. ovatus . In our study we isolated a single strain of B. fragilis in diarrheal stool of a person older than 54 years (74 years).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and antibiotic susceptibility of Bacteroides fragilis group isolated from stool samples in North Lebanon

Yehya

Hamzé

Mallat

et al. 2013

Braz. J. Microbiol.

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Fifty one strains of the Bacteroides fragilis group were isolated from 45 fecal samples. Classical phenotypic identification showed that 16 isolates were B. thetaiotaomicron, 12 B. uniformis, 9 B. eggerthii, 7 B. vulgatus, 3 B. caccae, 2 Parabacteroides distasonis with 1 identified B. ovatus and 1 B. fragilis. The 51 strains were tested for susceptibility against 16 antimicrobial agents and the MICs for metronidazole were determined. The tests showed that imipenem, meropenem and chloramphenicol were the most effective antibiotics (98%, 98% and 92.16% of susceptibility, respectively) followed by ticarcillin/clavulanic acid, piperacillin/tazobactam, rifampin (88.24% susceptibility), moxifloxacin 86.27% and tigecycline 84.31%. Ofloxacin and cefotaxime were the least effective antibiotics with 27.45% and 0% of activity respectively. Only six of the 51 isolated strains were resistant to metronidazole with MICs = 64 mg/L (1 strain) and > 256 mg/L (5 strains).

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Virulence markers and antimicrobial susceptibility of bacteria of the Bacteroides fragilis group isolated from stool of children with diarrhea in São Paulo, Brazil

Cited by 17 publications

References 35 publications

The prevalence of enterotoxin and antibiotic resistance genes in clinical and intestinal Bacteroides fragilis group isolates in Turkey

The prevalence of enterotoxin and antibiotic resistance genes in clinical and intestinal Bacteroides fragilis group isolates in Turkey

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Prevalence and antibiotic susceptibility of Bacteroides fragilis group isolated from stool samples in North Lebanon

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