Virulence evaluation of classical swine fever virus subgenotype 2.1 and 2.2 isolates circulating in China

Gong, Wenjie; Li, Junhui; ZunBao, Wang; Sun, Jixiang; Mi, Shijiang; Lu, Zexi; Dou, Zhihua; Sun, Yanjun; Wang, Pengjiang; Yuan, Ke; Zhang, Liying; Zhou, Xubin; Sun, He; Tu, Changchun

doi:10.1016/j.vetmic.2019.04.001

Cited by 24 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At present, subgenotype 2.1 strains are the dominant pandemic strains in China [ 6 , 10 , 22 ]. Three CSFV isolates were isolated from different provinces of China in the present study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Pathogenicity of Classical Swine Fever Virus Subgenotype 2.1c and 2.1d Strains from China

et al. 2020

View full text Add to dashboard Cite

Classical swine fever (CSF) caused by classical swine fever virus (CSFV) is a highly contagious and devastating disease. The traditional live attenuated C-strain vaccine is widely used to control disease outbreaks in China. Since 2000, subgenotype 2.1 has become dominant in China. Here, we isolated subgenotype 2.1c and 2.1d strains from CSF-suspected pigs. The genetic variations and pathogenesis of subgenotype 2.1c and 2.1d strains were investigated experimentally. We aimed to evaluate and compare the replication characteristics and clinical signs of subgenotype 2.1c and 2.1d strains with those of the typical highly virulent CSFV SM strain. In PK-15 cells, the three CSFV isolates exhibited similar replication levels but significantly lower replication levels compared with the CSFV SM strain. The experimental animal infection model showed that the pathogenicity of subgenotype 2.1c and 2.1d strains was less than that of the CSFV SM strain. According to the clinical scoring system, subgenotype 2.1c (GDGZ-2019) and 2.1d (HBXY-2019 and GXGG-2019) strains were moderately virulent. This study showed that the pathogenicity of CSFV field strains will aid in the understanding of CSFV biological characteristics and the related epidemiology.

show abstract

“…At present, subgenotype 2.1 strains are the dominant pandemic strains in China [ 6 , 10 , 22 ]. Three CSFV isolates were isolated from different provinces of China in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Since 2000, subgenotype 2.1 has become dominant in China. Among all subgenotypes of 2.1, subgenotypes 2.1c and 2.1d are currently the most widely prevalent in China [ 1 , 6 , 10 ]. The field virulence of CSFV is inconsistent with its genotype [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Pathogenicity of Classical Swine Fever Virus Subgenotype 2.1c and 2.1d Strains from China

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In summary, all four subgenotypes existed before 2008; 2.1 was the most predominant, followed by 1.1, 2.2, and 2.3 which were geographically scattered. Under pressure of the C strain vaccine (1.1), the prevalence of subgenotype 1.1 gradually decreased, and subgenotypes 2.2 and 2.3 gradually withdrew from the epidemic areas, leaving subgenotype 2.1, which is the most phylogenetically distant from the vaccine strain, the dominant CSFV strain in China (60). The epidemic strains in China are genetically diverse, the most prevalent genotype 2 strains are related to those from Europe, possibly originating from the same viral ancestor.…”

Section: Geographical Distribution Of Genotypesmentioning

confidence: 99%

Classical Swine Fever in China-An Update Minireview

Zhou

2019

Front. Vet. Sci.

View full text Add to dashboard Cite

Classical swine fever (CSF) remains one of the most economically important viral diseases of domestic pigs and wild boar worldwide. The causative agent is CSF virus, it is highly contagious, with high morbidity and mortality rates; as such, it is an OIE-listed disease. Owing to a nationwide policy of vaccinations of pigs, CSF is well-controlled in China, with large-scale outbreaks rarely seen. Sporadic outbreaks are however still reported every year. In order to cope with future crises and to eradicate CSF, China should strengthen and support biosecurity measures such as the timely reporting of suspected disease, technologies for reliable diagnoses, culling infected herds, and tracing possible contacts, as well as continued vaccination and support of research into drug and genetic therapies. This mini-review summarizes the epidemiology of and control strategies for CSF in China.

show abstract

“…CSF has been endemic in China since the early 20th century, and the prevention and control of this disease mainly depends on prophylactic vaccination, such as the Chinese lapinized vaccine [4]. However, compared to the classic strain, some newly emerging CSFV isolates could also be epidemic in many immunized pig farms or sporadically isolated from immunized pig farms, and showed distinct virulence and clinical manifestations [5,6].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalences of Classical Swine Fever Virus and Porcine Reproductive and Respiratory Syndrome Virus in Pigs in Hunan Province, China

Zhang

Cai

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Several infectious diseases including classical swine fever (CSF) and porcine reproductive and respiratory syndrome (PRRS) are responsible for major economic losses and represent a threat to the swine industry worldwide. Hunan is a province in south-central China, serological statistics will have certain effect on local breeding industry.The present study investigated the seroprevalences of classical swine fever virus (CSFV) and porcine reproductive and respiratory syndrome virus (PRRSV) in pigs from eight cities of Hunan province from 2017 to 2019. The samples were divided into two groups based on whether the hosts were immunized or not, and analysed by enzyme-linked immunosorbent assay (ELISA).Results: The seropositivity of CSFV and PRRSV between different parts of Hunan province in China was statistically significant. In unvaccinated group, our findings showed CSFV antibody in piglets' sera decreases gradually with increase of piglets' age whereas PRRSV-specific antibodies may appear in various growth stages. In immunized group, the average seropositive rate of CSFV antibody was 82.2%, while the rate of PRRSV antibody was relatively higher (84.4%).Conclusions: Results from this study suggested that a serological investigation on these two major infectious diseases (CSF and PRRS) among various growth stages of pigs will provide a basis for further development of more effective preventions and control measures.

show abstract

Virulence evaluation of classical swine fever virus subgenotype 2.1 and 2.2 isolates circulating in China

Cited by 24 publications

References 31 publications

Comparison of the Pathogenicity of Classical Swine Fever Virus Subgenotype 2.1c and 2.1d Strains from China

Comparison of the Pathogenicity of Classical Swine Fever Virus Subgenotype 2.1c and 2.1d Strains from China

Classical Swine Fever in China-An Update Minireview

Seroprevalences of Classical Swine Fever Virus and Porcine Reproductive and Respiratory Syndrome Virus in Pigs in Hunan Province, China

Contact Info

Product

Resources

About