Virucidal efficacy of povidone-iodine-containing disinfectants

Abstract

Aims: The objective of this study was to evaluate virucidal efficacy of the commercially available povidone‐iodine formulations Betaisodona® solution and Betaseptic Mundipharma® (Mundipharma). Methods and Results: The quantitative suspension test for virucidal testing of biocides according to the German guideline was used as method. The use of Betaisodona® solution resulted in virucidal efficacy, corresponding to ≥104‐fold reduction in viral titre, against vaccinia virus, bovine viral diarrhoea virus and polyomavirus SV40 within 0·5 min and adenovirus type 5 within 3–5 min without and with organic load. For inactivation of the most resistant poliovirus type 1, a time interval of ≥60 min was needed. By contrast, Betaseptic Mundipharma® inactivated significantly all model viruses for virucidal testing including poliovirus type 1 within 5 min independently from the addition of proteins. Conclusions: Betaisodona® solution shows a good efficacy against enveloped model viruses as well as against some nonenveloped human viruses, e.g. adenovirus and polyomavirus. Betaseptic Mundipharma® has an excellent virucidal efficacy including the inactivation of the most resistent poliovirus type 1. Significance and Impact of the Study: The findings of this study make Betaseptic Mundipharma® suitable for virucidal disinfection of the skin within short time intervals.

Lung injury induced by the pulmonary instillation of povidone-iodine in rats

“…Povidone-iodine (polyvinylpyrrolidone iodine, PI), which is a broad-spectrum microbicide with activity against bacteria, viruses, fungi, and protozoans [1,2], is commonly used as a pre-and postoperative antiseptic and a disinfectant of skin wounds. PI is also used as a gargle in various concentrations to (a) disinfect the oral cavity before oral surgery [3], (b) minimize the likelihood of developing respiratory tract infections in mechanically ventilated patients [4][5][6], and (c) forestall the common cold and influenza [7].…”

Virucides in apiculture: persistence of surrogate enterovirus under simulated field conditions

“…However, the reduction of titre did not reach 4 log 10 (99.99%). The virucidal effect of iodophor‐based disinfectants on both enveloped and non‐enveloped human viruses was earlier clearly demonstrated by quantitative suspension tests under dirty conditions . Nevertheless, failures of iodine‐based disinfectants under the dirty conditions simulating field organic contamination were described repeatedly.…”

Comparison of disinfective power according to application order of 70% isopropyl alcohol and 10% povidone-iodine

“…Iodophor, which is commercially available for skin preparation and skin wounds in clinical practice, is the same as PVP-I or betadine. In PVP-I, polyvinylpyrrolidone polymer (or povidone) forms a complex with iodine [16] and acts as a reservoir for free iodine [17,18]. Unlike alcohol, the disinfectant effect is sustained, but iodine is released from carrier molecules and several minutes are required for the maximal antimicrobial effect [15].…”