This chapter will develop three categories of relationship concepts, and other key ideas and practices as threshold concepts in a holistic and spiritual pedagogy used in a master's program in holistic and integrative education. These understandings will be situated within a context of a post-formal perspective (Gidley) and research in socio-neurobiology, describing various practices and narratives that proved successful, and led to this program being featured in the Journal for Transformative Learning as a model of transformative education. The chapter will conclude with a discussion on spiritual activism, especially building upon the use of the international earth charter.