The fast pace of advances within the Industry 4.0 era has had a direct impact on the process of technology transfer, as well as brought forth new and hitherto unknown challenges. This study pursues the goal to delineate the challenges and/or limitations of the I4’s process of technology transfer in terms of anthropotechnological aspects. For this purpose, the combination of two methodologies, PRISMA and Methodi Ordinatio, was carried out. The final portfolio analysis was divided into quantitative and qualitative sections. As a result, the current and recurring challenges of this interaction were reported in an overlap. Moreover, it was demonstrated that most studies have been focusing their attention on what involves a more holistic issue of the whole scenario, be they in the organizational, educational, cultural, governmental, security, human capital, technologies, innovations, or sustainable development issues. Finally, this research can serve as a starting point for further researches, as well as contribute to the understanding of industries during the implementation of the Industry 4.0 and their challenges regarding processes of technology transfer.