Recent Advances in the 3D Physiological Human 2009
DOI: 10.1007/978-1-84882-565-9_5
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Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Abstract: Pulmonary valve replacement (PVR) is a pivotal treatment for patients who suffer from chronic pulmonary valve regurgitations. Two PVR techniques are becoming prevalent: a minimally invasive approach and an open-heart surgery with direct right ventricle volume reduction. However, there is no common agreement about the postoperative outcomes of these PVR techniques and choosing the right therapy for a specific patient remains a clinical challenge. We explore in this paper how image processing algorithms, electro… Show more

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Cited by 11 publications
(9 citation statements)
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“…The complete multi-physics model can therefore be successfully implemented on SOFA, the simulation time is short enough so that numerous parameter estimation techniques can be though of. Moreover, several cardiac therapy simulations are made possible with SOFA interactivity, such as Cardiac Resynchronization Therapy or cardiac Radio-Frequency Ablation [20], [23].…”
Section: Results Of the Simulationmentioning
confidence: 99%
“…The complete multi-physics model can therefore be successfully implemented on SOFA, the simulation time is short enough so that numerous parameter estimation techniques can be though of. Moreover, several cardiac therapy simulations are made possible with SOFA interactivity, such as Cardiac Resynchronization Therapy or cardiac Radio-Frequency Ablation [20], [23].…”
Section: Results Of the Simulationmentioning
confidence: 99%
“…Our method is a modification of the approaches presented by Ringenberg et al and Mansi et al (Mansi et al 2009, Ringenberg et al 2014) who utilized the so-called variational implicit functions (Turk and O’Brien 1999) to reconstruct patient-specific ventricular geometries from Lo-res clinical images. In brief, to reconstruct a surface from n landmark points c j , j = 1,2, …, n , the variational implicit functions method builds a smooth function f in 3D space such that f = 0 at these landmark points.…”
Section: Methodsmentioning
confidence: 99%
“…We performed the reconstruction separately for the epi- and endocardial left and right ventricles (LV/RV) and then merged the results to create the full ventricular geometry. Compared to the approach by Mansi et al (Mansi et al 2009), we automatically detected the landmark points inside and outside of each contour, rather than manually placing those points. In contrast with the technique by Ringenberg et al (Ringenberg et al 2014), we did not contour the same part of myocardial boundary more than once.…”
Section: Methodsmentioning
confidence: 99%
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“…Ici encore, le modèle, bien que relativement simple, permet de simuler un mouvement réaliste du coeur, reproduisant notamment le mouvement de torsion caractéristique du muscle. La personnalisation des paramè-tres électriques (principalement la conductivité locale) et mécaniques (principalement la contractilité locale du myocarde) sur des zones correspondant à des territoires vasculaires est encore un sujet de recherche actif, mais des premiers résultats prometteurs sont obtenus à partir de méthodes itératives qui comparent les simulations électriques et méca-niques aux observations (images IRM et électrophysiologie 3D) et font évoluer progressivement les paramètres des modèles pour rapprocher simulations et observations à chaque itération [17,18]. Un modèle cardiaque ainsi personnalisé (Figure 4) permettra de prédire le bénéfice attendu de différentes thérapies, notamment de l'ablation radiofréquence de tissus cardiaques pour traiter certains troubles du rythme.…”
Section: Fonction Cardiaqueunclassified