Virtual Endoscopy - Comparison with Colonoscopy in the Detection of Space-Occupying Lesions of the Colon

Kay, Clive; Kulling, Daniel; Hawes, R.; Young, Jeremy W. R.; Cotton, Peter B.

doi:10.1055/s-2000-100

Cited by 93 publications

(28 citation statements)

References 23 publications

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“…We included 47 prospective studies involving 10,546 patients that compared CTC to the reference standard of CC or surgery [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63]. Table 2 shows detailed information from individual studies.…”

Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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Background: The real accuracy of computed tomographic colonography (CTC) is still unknown. Objective: To perform a meta-analysis of the diagnostic accuracy of CTC for the detection of polyps and colorectal tumors. Methods: Selection of studies:Studiesassessing the accuracy of CTC for the detection of colorectal polyps and tumors were selected. Data synthesis:Meta-analyses combining sensitivities, specificities and likelihood ratios (LRs) for the diagnosis of polyps and colorectal tumors were carried out. Results: Forty-seven studies, providing data of 10,546 patients, were included. Overall per-polyp sensitivity of CTC was 66% (64–68%), for polyps 6–9 mm in size it was 59% (56–61%), and 76% (73–79%) for polyps larger than 9 mm. Overall per-patient sensitivity was 69% (66–72%), for polyps 6–9 mm 60% (56–65%), and 83% (70–85%) for lesions larger than 9 mm. Overall CTC specificity was 83% (81–84%). Positive and negative LRs were 2.9 (1.8–4) and 0.38 (0.27–0.53), respectively; for polyps 6–9 mm in size, they were 3.8 (2.5–5.7) and 0.4 (0.27–0.59), and 12.3 (7.7–19.4) and 0.19 (0.12–0.3) for polyps larger than 9 mm. Conclusion: CTC is highly specific for the detection of colorectal polyps and tumors. Some studies reported high sensitivities, but the results of the studies were highly heterogeneous, while the studied variables explained only part of this discrepancy.

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Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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“…Reported clinical series [9][10][11][12] showed encouraging results. Hara et al, in a series of 70 patients, reported a sensitivity of 75% for lesions greater than 10 mm.…”

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confidence: 94%

Performance of multidetector computed tomography colonography compared with conventional colonoscopy

Gluecker

Dorta²,

Keller³

et al. 2002

Gut

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Background and aims: This was a prospective blinded study to compare computed tomography (CT) colonography, performed with multidetector arrays CT scan (MDCT), with conventional colonoscopy for the detection of colorectal neoplasia. Methods: Fifty patients were examined by MDCT after standard bowel preparation and rectal air insufflation in the supine and prone positions. Data sets were examined by one radiologist and one gastroenterologist blinded to the patient's history and colonoscopy results. Patients subsequently underwent colonoscopy on the same day, which served as the gold standard. Results: Nine of 11 lesions >10 mm (82%), 5/15 lesions of 6-9 mm (33%), and 1/42 polyps <5 mm (3%) were detected by MDCT colonography. One false positive result for a structure larger than 10 mm was described. Nineteen of 21 patients who had no lesions during conventional colonoscopy were considered free of lesions by MDCT colonography, yielding a per patient specificity of 90%. Conclusion: MDCT colonography provides good data quality and has good sensitivity and specificity for the detection of colonic lesions of 10 mm or more.

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“…Advances in computerized tomographic (CT) techniques and the supportive computer software for these devices may soon alter the need for invasive colon screening techniques [8]. CT colonography or virtual colonoscopy has advanced to a point where this may be the optimal initial screening technique for colorectal cancer [11].…”

Section: Discussionmentioning

confidence: 99%

Advanced proximal colon cancer

et al. 2001

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Virtual Endoscopy - Comparison with Colonoscopy in the Detection of Space-Occupying Lesions of the Colon

Abstract: Virtual colonoscopy is feasible, well tolerated, and capable of detecting most lesions greater than 10 mm in diameter. This technique is continuing to be developed and warrants further evaluation as a diagnostic and screening tool in colorectal neoplasia.

Cited by 93 publications

References 23 publications

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Performance of multidetector computed tomography colonography compared with conventional colonoscopy

Advanced proximal colon cancer

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