Performance of multidetector computed tomography colonography compared with conventional colonoscopy

Abstract

Background and aims: This was a prospective blinded study to compare computed tomography (CT) colonography, performed with multidetector arrays CT scan (MDCT), with conventional colonoscopy for the detection of colorectal neoplasia. Methods: Fifty patients were examined by MDCT after standard bowel preparation and rectal air insufflation in the supine and prone positions. Data sets were examined by one radiologist and one gastroenterologist blinded to the patient's history and colonoscopy results. Patients subsequently underwent colonoscopy on the same day, which served as the gold standard. Results: Nine of 11 lesions >10 mm (82%), 5/15 lesions of 6-9 mm (33%), and 1/42 polyps <5 mm (3%) were detected by MDCT colonography. One false positive result for a structure larger than 10 mm was described. Nineteen of 21 patients who had no lesions during conventional colonoscopy were considered free of lesions by MDCT colonography, yielding a per patient specificity of 90%. Conclusion: MDCT colonography provides good data quality and has good sensitivity and specificity for the detection of colonic lesions of 10 mm or more.

Relationships of Colorectal Cancer with Dietary Factors and Public Health Indicators: an Ecological Study

“…orange and lemon) and vegetables have B and C vitamins, and antioxidant elements which decrease the CRC incidence (Stoneham et al, 2000;Gluecker et al, 2002;Smith et al, 2007;Center et al, 2009). …”

Performance value of high risk factors in colorectal cancerscreening in China

“…Colonoscopy is often regarded as the "gold standard" for detection of CRC [11,12] . Direct colonoscopy screening is the most accurate test for CRC.…”

CT Colonography (Virtual Colonoscopy): Technique, Indications and Performance

“…The performance of CTC for small polyps less than 6 mm in size is poor, but from a clinical perspective these are the least important lesions. Based on available results, CTC seems to have an excellent specificity record (false-positive results of up to 10%) with specificity for polyps larger than 10 mm of 90–95% [40,41,42,43,44,45,46,47,48,49,50]. Recent meta-analyses [54, 55] showed a pooled per patient (finding a patient with polyps irrespective of the number of polyps found) sensitivity and specificity for polyps 10 mm or larger of 88 and 95, and 84 and 65% pooled per patient sensitivity for polyps 6–9 mm and 5 mm or smaller, respectively.…”

“…Multiple studies have documented the ability of CTC to detect patients with polyps greater than 10 mm in size with sensitivities ranging from 50 to 100% [10, 21, 23, 27,40,41,42,43,44,45,46,47,48,49,50]. The wide range in sensitivity for the detection of polyps may be explained by significant differences in the techniques used in data acquisition and analysis [51,52,53] and by the readers’ expertise.…”