VIRTOPSY – The Swiss virtual autopsy approach

Thali, Michael J.; Jackowski, Christian; Oesterhelweg, Lars; Ross, Steffen; Dirnhofer, Richard

doi:10.1016/j.legalmed.2006.11.011

Cited by 184 publications

(124 citation statements)

References 10 publications

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“…In a forensic investigation, the approximate age of a pericontusional traumatic white matter lesion could be assessed to either confirm or call into question the reports of witnesses or other evidence (Case et al, 2001;Oehmichen et al, 2003). A growing body of forensic imaging literature supports this possibility (Kahana and Hiss, 1999;Thali et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury

Donald¹,

Dikranian²,

Bayly³

et al. 2007

J. Neurosci.

395

337

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Traumatic axonal injury (TAI) may contribute greatly to neurological impairments after traumatic brain injury, but it is difficult to assess with conventional imaging. We quantitatively compared diffusion tensor imaging (DTI) signal abnormalities with histological and electron microscopic characteristics of pericontusional TAI in a mouse model. Two DTI parameters, relative anisotropy and axial diffusivity, were significantly reduced 6 h to 4 d after trauma, corresponding to relatively isolated axonal injury. One to 4 weeks after trauma, relative anisotropy remained decreased, whereas axial diffusivity "pseudo-normalized" and radial diffusivity increased. These changes corresponded to demyelination, edema, and persistent axonal injury. At every time point, DTI was more sensitive to injury than conventional magnetic resonance imaging, and relative anisotropy distinguished injured from control mice with no overlap between groups. Remarkably, DTI changes strongly predicted the approximate time since trauma. These results provide an important validation of DTI for pericontusional TAI and suggest novel clinical and forensic applications.

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Section: Discussionmentioning

confidence: 99%

Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury

Donald¹,

Dikranian²,

Bayly³

et al. 2007

J. Neurosci.

395

337

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show abstract

“…Ayrıca, yabancı cisimler üç boyutlu olarak vücut içinde topografik komşulukları gösterebildiğinden otopside uygun bir şekilde çıkartılmalarını hızlandırabilir. Yivli silah yaralarında merminin tespiti ve çı-karılma işleminin radyografik kontrol altında yapılması vücut-tan merminin hasar görmeden çıkarılmasını sağlamaktadır (4,5,8,12).…”

Section: Tomografi (çKbt)unclassified

“…Mikro-BT tarayıcısı 10 µm'den 100 µm'e kadar rezolüsyon aralığın-da izotropik rezolüsyonlu üç boyutlu volüm görüntüleyebilmek-tedir. Sistem dört mm'den 40 mm'e çapa kadar olan örnekleri inceleme kapasitesine sahiptir (1,5). Mikro-BT; 1990'ların ortalarında tıp alanına sunulmuş, osteoporoz araştırması gibi alanlarda kullanılmış ve bunu transgenik sıçanlar üzerindeki çalışmalar izlemiştir.…”

Section: A-) Mikro-btunclassified

“…Bunun yanında dijital radyoloji alt yapısının kurulmasının gerekliliği ve şimdi-lik pahalı olması, cesetlerin veya parçalarının dijital radyoloji servisine taşın-ma zorunluluğu, uygun bilgisayar yazılım araçları-nın kullanımı ve verilerin doğru y o r u m l a n a b i lmesi için eğitim zorunluluğunun olması; virtopsinin kullanımındaki olumsuz yönler olarak söylenebilir (1,3,5).…”

Section: Sonuçunclassified

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The Importance Of Virtopsy In The Forensic Autopsy

Çelik¹,

Beyaztaş²,

Bütün³

2012

Adli Tip Derg

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“…Multidetector computed tomography (MDCT) is the most often used technique [1], and is more preferred than MRI for a number of reasons, including the rapid examination, relatively easy handling, and lower cost. Furthermore, the spatial resolution and high sensitivity of MDCT allow the detection of small collections of gas in bodies [1][2][3][4][5][6][7][8][9][10][11], including quantities smaller than those that can be detected using standard autopsy techniques.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a postmortem radiological alteration index: the RA-Index

et al. 2012

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This study aimed to derive an index quantifying the state of alteration of cadavers by quantifying the presence of gas in the body using postmortem multidetector computed tomography (MDCT) imaging, and to validate the index by defining its sensitivity and specificity. The RA (radiological alteration)-index was derived from postmortem MDCT data from 118 nontraumatically deceased people. To validate the index, 100 additional scanned bodies (50 % traumatically deceased) were retrospectively examined by two independent observers. Presence of gas at 82 sites was assessed by a radiologist, whereas a forensic pathologist only investigated the seven sites used for the RA-index. The RA-index was highly correlated to the overall presence of gas in all 82 sites (R 2 00.98 in the derivation set and 0.85 in the validation set). Semiquantitative evaluation of gas presence in each site showed moderate reliability (Cohen's kappa range, 0.41-0.78); nevertheless, the overall RA-index was very reliable (ICC 2,1 00.95; 95 % CI 0.92-0.96). Examiner using the RA-index detected heart cavities full of gas with a sensitivity of 100 % (95 % CI 51.7-100) and a specificity of 98.8 % (92.6-99.9). We conclude that determining the presence of gas at seven sites is a valid means to measure the distribution of gas due to cadaveric alteration in the entire body. The RA-index is rapid, easy-touse, and reliable for nonexperienced users, and it is a valid method to suspect the normal presence of gas from cadaveric alteration. MDCT can be used to screen for gas embolism and to give indications for gas composition analysis (gas chromatography).

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VIRTOPSY – The Swiss virtual autopsy approach

Cited by 184 publications

References 10 publications

Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury

Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury

The Importance Of Virtopsy In The Forensic Autopsy

Development and validation of a postmortem radiological alteration index: the RA-Index

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