Virome and Blood Meal-Associated Host Responses in Ixodes persulcatus Naturally Fed on Patients

Li, Liangjing; Ning, Nianzhi; Zheng, Yuan-Chun; Chu, Yan-Li; Cui, Xiaoming; Zhang, Mingzhu; Guo, Wenbin; Wei, Ran; Liu, Hongbo; Sun, Yi; Ye, Jinling; Jiang, Bao-Gui; Yuan, Tingting; Li, Jie; Bian, Cai; Bell‐Sakyi, Lesley; Wang, Hui; Jiang, Jia-Fu; Song, Jie; Cao, Wu‐Chun; Lam, Tommy Tsan-Yuk; Ni, Xue-Bing; Jia, Na

doi:10.3389/fmicb.2021.728996

Cited by 4 publications

(1 citation statement)

References 58 publications

(67 reference statements)

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“…In fact, JMTV was found in high prevalence in R. microplus from China (53–63%), Brazil (25–67%), Trinidad and Tobago (6–46%), and the French Antilles (24–77%) over the years ( Maruyama et al, 2014 ; Qin et al, 2014 ; Souza et al, 2018 ; Pascoal et al, 2019 ; Sameroff et al, 2019 ; Temmam et al, 2019 ; Gondard et al, 2020 ; Guo J. J. et al, 2020 ; Kobayashi et al, 2021 ; Xu et al, 2021 ). However, the nature of the samples containing JMTV RNA extends beyond this species and includes 25 additional tick species from several genera, Rhipicephalus, Amblyomma, Dermacentor, Haemaphysalis, Hyalomma , and Ixodes ( Maruyama et al, 2014 ; Qin et al, 2014 ; Souza et al, 2018 ; Dinçer et al, 2019 , 2022 ; Jia et al, 2019 ; Meng et al, 2019 ; Pascoal et al, 2019 ; Sameroff et al, 2019 ; Temmam et al, 2019 ; Gondard et al, 2020 ; Guo J. J. et al, 2020 ; Gómez et al, 2020 ; Ternovoi et al, 2020b ; Xu et al, 2020 , 2021 ; Bratuleanu et al, 2021 ; Li et al, 2021 ; Shi et al, 2021 ; Ogola et al, 2022 ), as well as two mosquito species ( Qin et al, 2014 ; Parry et al, 2021 ). The local prevalence of JMTV RNA in tick species such as Hae.…”

Section: Tick- and Vertebrate-associated Jingmenvirusesmentioning

confidence: 99%

Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses

2022

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Jingmenviruses are a group of viruses identified recently, in 2014, and currently classified by the International Committee on Taxonomy of Viruses as unclassified Flaviviridae. These viruses closely related to flaviviruses are unique due to the segmented nature of their genome. The prototype jingmenvirus, Jingmen tick virus (JMTV), was discovered in Rhipicephalus microplus ticks collected from China in 2010. Jingmenviruses genomes are composed of four to five segments, encoding for up to seven structural proteins and two non-structural proteins, both of which display strong similarities with flaviviral non-structural proteins (NS2B/NS3 and NS5). Jingmenviruses are currently separated into two phylogenetic clades. One clade includes tick- and vertebrate-associated jingmenviruses, which have been detected in ticks and mosquitoes, as well as in humans, cattle, monkeys, bats, rodents, sheep, and tortoises. In addition to these molecular and serological detections, over a hundred human patients tested positive for jingmenviruses after developing febrile illness and flu-like symptoms in China and Serbia. The second phylogenetic clade includes insect-associated jingmenvirus sequences, which have been detected in a wide range of insect species, as well as in crustaceans, plants, and fungi. In addition to being found in various types of hosts, jingmenviruses are endemic, as they have been detected in a wide range of environments, all over the world. Taken together, all of these elements show that jingmenviruses correspond exactly to the definition of emerging viruses at risk of causing a pandemic, since they are already endemic, have a close association with arthropods, are found in animals in close contact with humans, and have caused sporadic cases of febrile illness in multiple patients. Despite these arguments, the vast majority of published data is from metagenomics studies and many aspects of jingmenvirus replication remain to be elucidated, such as their tropism, cycle of transmission, structure, and mechanisms of replication and restriction or epidemiology. It is therefore crucial to prioritize jingmenvirus research in the years to come, to be prepared for their emergence as human or veterinary pathogens.

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Section: Tick- and Vertebrate-associated Jingmenvirusesmentioning

confidence: 99%

Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses

2022

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Jingmen tick virus: an emerging arbovirus with a global threat

Wu,

Zhang,

Zhang

et al. 2023

mSphere

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Jingmen tick virus (JMTV), belonging to the Flaviviridae family, is a novel segmented RNA virus identified in 2014 in the Jingmen region of Hubei Province, China. Up to now, JMTV has been detected in a variety of countries or regions in Asia, Europe, Africa, and the Americas, involving a wide range of arthropods and mammals, and even humans. The JMTV genome is composed of four linear RNA segments, two of which are derived from flaviviruses, while the other two segments are unique to JMTV and has no matching virus. Currently, JMTV has been shown to have a pathogenic effect on humans. Humans who had been infected would develop viremia and variable degrees of clinical symptoms. However, the pathogenic mechanism of JMTV has not been elucidated yet. Therefore, it is crucial to strengthen the epidemiological surveillance and laboratory studies of JMTV.

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Skin infectome of patients with a tick bite history

Zhang

Zheng²,

Chu³

et al. 2023

Front. Cell. Infect. Microbiol.

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IntroductionTicks are the most important obligate blood-feeding vectors of human pathogens. With the advance of high-throughput sequencing, more and more bacterial community and virome in tick has been reported, which seems to pose a great threat to people.MethodsA total of 14 skin specimens collected from tick-bite patients with mild to severe symptoms were analyzed through meta-transcriptomic sequencings.ResultsFour bacteria genera were both detected in the skins and ticks, including Pseudomonas, Acinetobacter, Corynebacterium and Propionibacterium, and three tick-associated viruses, Jingmen tick virus (JMTV), Bole tick virus 4 (BLTV4) and Deer tick mononegavirales-like virus (DTMV) were identified in the skin samples. Except of known pathogens such as pathogenic rickettsia, Coxiella burnetii and JMTV, we suggest Roseomonas cervicalis and BLTV4 as potential new agents amplified in the skins and then disseminated into the blood. As early as 1 day after a tick-bite, these pathogens can transmit to skins and at most four ones can co-infect in skins.DiscussionAdvances in sequencing technologies have revealed that the diversity of tick microbiome and virome goes far beyond our previous understanding. This report not only identifies three new potential pathogens in humans but also shows that the skin barrier is vital in preventing horizontal transmissions of tick-associated bacteria or virus communities to the host. It is the first research on patients’ skin infectome after a tick bite and demonstrates that more attention should be paid to the cutaneous response to prevent tick-borne illness.

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Virome and Blood Meal-Associated Host Responses in Ixodes persulcatus Naturally Fed on Patients

Cited by 4 publications

References 58 publications

Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses

Jingmenviruses: Ubiquitous, understudied, segmented flavi-like viruses

Jingmen tick virus: an emerging arbovirus with a global threat

Skin infectome of patients with a tick bite history

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