Jingmen tick virus: an emerging arbovirus with a global threat

Wu, Zhen; Zhang, Ming; Zhang, Yuli; Lu, Ke; Zhu, Wenbing; Feng, Shuo; Qi, Jun; Niu, Guoyu

doi:10.1128/msphere.00281-23

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Based on the curated dataset, the distribution and abundance of hematophagous arthropods suggest that the United States, Russia, and China harbor the highest number of vector insects, notably mosquitoes and ticks, acting as primary carriers for arthropod-borne viruses (Y.-J. S. Huang et al, 2019b; Wu et al, 2023). Among the viruses carried by these arthropods, RNA viruses, specifically those classified as dsRNA under the third Baltimore group, dominate.…”

Section: Discussionmentioning

confidence: 99%

Ensemble Learning: Predicting Human Pathogenicity of Hematophagous Arthropod Vector-Borne Viruses

Hu,

Zhao,

Jin

et al. 2023

Preprint

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Hematophagous arthropods occupy a pivotal role in ecosystems, serving as vectors for a wide array of pathogens with significant implications for public health. Their capacity to harbor and transmit viruses through biting actions creates a substantial risk of zoonotic spillover. Despite the advancements in metagenomic approaches for virus discovery in vectors, the isolation and cultivation of viruses still pose significant challenges, thereby limiting comprehensive assessments of their pathogenicity. Here, we curated two datasets: one with 294 viruses, characterized by 37 epidemiological features, encompassing virus information and host associations; the second with 71,622 sequences of hematophagous arthropod vector-borne viruses, annotated with 33 sequence features. Two XGBoost models were developed to predict arbovirus human pathogenicity: one integrating macroscopic eco-epidemiological data, the other incorporating virus-related sequence features. The macroscopic model identified non-vector host transmission as a key determinant, especially involving Perissodactyla, Artiodactyla, and Carnivora Order. The sequence-based model demonstrated that viral adhesion and viral invasion had distinct trends with consistent increase and decrease in the likelihood of virus pathogenicity to humans, respectively. With validated through an independent dataset, the model exhibited a congruous alignment with documented pathogenicity outcomes. Together, the models offer a holistic framework for assessing the pathogenic potential of viruses transmitted by hematophagous arthropods.

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Section: Discussionmentioning

confidence: 99%

Ensemble Learning: Predicting Human Pathogenicity of Hematophagous Arthropod Vector-Borne Viruses

Hu,

Zhao,

Jin

et al. 2023

Preprint

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“…Jingmenviruses are separated into two phylogenetic clades: one associated with ticks and vertebrates and the other with insects. JMTV has been detected in various countries and regions across Asia, Europe, Africa, and the Americas, involving a wide range of arthropods as well as mammals, including humans [ 42 ]. In humans, JMTV has been linked to sporadic cases of febrile illness in multiple patients [ 43 ].…”

Section: Ticks-borne Diseases: Transmission Of Viruses From Ticks To ...mentioning

confidence: 99%

“…In humans, JMTV has been linked to sporadic cases of febrile illness in multiple patients [ 43 ]. Presently, it is recognized as an emerging arbovirus with a global threat [ 42 ].…”

Section: Ticks-borne Diseases: Transmission Of Viruses From Ticks To ...mentioning

confidence: 99%

Tick-borne viruses and their risk to public health in the Caribbean: Spotlight on bats as reservoirs in Cuba

Antúnez,

Marín Montesinos,

Corduneanu

et al. 2024

Heliyon

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“…These studies demonstrated that JMTV has wide distribution, and broad host spectrum. The Pairwise distance analysis of these JMTV strains reported by Zhen Wu et al showed that the nucleotide homologies of segment 1–4 of JMTV strains from different regions ranged from 69.4 to 100%, 57.4 to 100%, 68 to 99.9%, and 59.5 to 100%, respectively ( 18 ). These studies indicate that JMTV is conservative in local ecosystem however significant genetic diversities were detected in different countries and continents.…”

Section: Introductionmentioning

confidence: 99%

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

Liu,

Hu,

Cao

et al. 2024

Front. Vet. Sci.

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Jingmen tick virus (JMTV) is a newly identified segmented flavivirus that has been recognized in multiple hosts, such as humans, buffalos, bats, rodents, mosquitos and ticks. Various clinical cases and studies manifested that JMTV is a true arbovirus with wide host spectrum and showed potential threats toward public health. JMTV has been reported in multiple countries in Asia, Europe, Africa, and America. Moreover, wild boars serve as an important intermediary between humans and the wild ecological system. In China, it has been reported in nine provinces, while the prevalence and the distribution of JMTV in most regions including Jiangxi Province are still unknown. Thus, to profile the distribution of JMTV in Jiangxi Province, an epidemiological investigation was carried out from 2020 to 2022. In current study, 66 ticks were collected from 17 wild boars in Jiangxi Province. The results showed that 12 out of 66 ticks were JMTV positive, indicating JMTV is prevalent in ticks and boars in Jiangxi Province. The genome sequences of JMTV strain WY01 were sequenced to profile viral evolution of JMTV in China. Phylogenetic analysis divided JMTV strains into two genotypes, Group I and Group II. WY01 belongs to Group II and it shares the closest evolutionary relationship with the Japan strains rather than the strains from neighboring provinces in China suggesting that JMTV might have complex transmission routes. Overall, current study, for the first time, reported that JMTV is prevalent in Jiangxi Province and provided additional information concerning JMTV distribution and evolution in China.

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Jingmen tick virus: an emerging arbovirus with a global threat

Cited by 4 publications

References 33 publications

Ensemble Learning: Predicting Human Pathogenicity of Hematophagous Arthropod Vector-Borne Viruses

Ensemble Learning: Predicting Human Pathogenicity of Hematophagous Arthropod Vector-Borne Viruses

Tick-borne viruses and their risk to public health in the Caribbean: Spotlight on bats as reservoirs in Cuba

Identification and phylogenetic analysis of Jingmen tick virus in Jiangxi Province, China

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