Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

Martínez-Lapiscina, Elena H.; Clavero, Pedro; Toledo, Estefanía; Julián, Beatriz San; Sánchez‐Tainta, Ana; Corella, Dolores; Lamuela-Raventós, Rosa M.; Martínéz, J. Alfredo

doi:10.1007/s12603-013-0027-6

Cited by 223 publications

(172 citation statements)

References 52 publications

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…In brief, time of adherence to the MD varied between RCTs, this being 10 d in one study (59), 12 wk in another study (60), and 6.5 y in the 3 publications of the PREDIMED (PREvencioń con DIeta MEDiterrańea) study (56)(57)(58). Adherence to the MD was assessed in most studies with the use of either a score developed by Panagiotakos et al (MedDietScore; 61) or a score developed by Trichopolou et al (MeDi score; 31), whereas 7 studies modified the MeDi score to better suit the populations they were studying, and 1 study used a novel "Mediterranean-style diet" score.…”

Section: Resultsmentioning

confidence: 99%

“…In brief, the outcomes assessed varied in that 9 studies included risk of AD as outcome, 9 studies measured cognitive impairment, and 23 studies measured cognitive function and decline. Of these, 1 study measured all 3 outcomes (31), 2 studies measured both cognitive impairment and AD (47,54), 2 studies measured cognitive function and cognitive impairment (33,57), and 3 studies measured cognitive function and AD (37,45,53).…”

Section: Resultsmentioning

confidence: 99%

“…Participants assigned to the MD enriched with nuts (MedDiet+Nuts) did not differ from controls (57). Because this publication is based on a subsample of the PREDIMED study, which originally was designed to assess the MD for the primary prevention of cardiovascular events, the study sample might not be sufficient, thus leading to estimates with wide CIs.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

331

212

View full text Add to dashboard Cite

A growing body of evidence suggests that adherence to the Mediterranean diet (MD) may protect against cognitive decline and dementia. Many epidemiologic studies and several randomized controlled trials (RCTs) have found positive effects of the MD on cognitive function, but findings remain inconsistent. The aim of this systematic review was to provide an update on the current knowledge of the effects of the MD on cognitive function, cognitive impairment, Alzheimer disease (AD), and all-type dementia. Five databases were searched-PubMed, Embase, CINAHL, CENTRAL, and PsycINFO (1806 to 25 May 2015)-with the use of prespecified criteria. Human studies that were published in English without any restriction on study type, population assessed, intervention period, follow-up time, or publication date, and that examined the association between adherence to the MD and cognitive function or dementia symptoms (as measured by cognitive function tests), were included. Only primary publication types were included. Thirty-two studies from 25 unique cohorts, including 5 RCTs and 27 observational studies, met the inclusion criteria. The majority of studies showed that the MD was associated with improved cognitive function, a decreased risk of cognitive impairment or decreased risk of dementia, or AD. Three studies found no correlation between the MD and AD, 3 further studies found no association between the MD and cognitive impairment, and 5 studies found no association between the MD and cognitive function. There was large heterogeneity, and studies differed with regard to quality. Based on the findings and the limitations in study design, we conclude that adherence to the MD is associated with better cognitive performance. However, it should be noted that the majority of findings come from epidemiologic studies that provide evidence for a correlation between the MD and cognition but not for a cause-and-effect relation. More controlled trials are required to establish a causational relation. Adv Nutr 2016;7:889-904.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Petersson

Philippou

2016

Advances in Nutrition

331

212

View full text Add to dashboard Cite

show abstract

“…In fact, polyphenols and resveratrol mediate multiple of the previously described pathways such as SIRTs, AMPK and mTOR (Lam et al 2013). In longitudinal clinical interventions conducted in humans, increased consumption of polyphenol-rich and Mediterranean-type food items such as extra-virgin olive oil and nuts has been associated with markers of healthy aging such as improvement of cardiovascular risk factors and cognition (Valls-Pedret et al 2012;Martinez-Lapiscina et al 2013;Zhu et al 2014;Houston et al 2015). Moreover, a resveratrol supplementation study in healthy aged individuals improved brain functional connectivity, which correlated with improved glucose metabolism and memory (Witte et al 2014).…”

Section: Calorie Restriction Mimetics: the Case Of Polyphenolsmentioning

confidence: 99%

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes

et al. 2015

View full text Add to dashboard Cite

Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. New methods of analysis are required to tackle the complexity of the interplay between nutritional interventions and aging, and to make sense of a growing amount of -omics data being produced for this purpose. In this paper, we review how various systems biology-inspired methods of analysis can be applied to the study of the molecular basis of nutritional interventions promoting healthy aging, notably caloric restriction and polyphenol supplementation. We specifically focus on the role that different versions of network analysis, molecular signature identification and multiomics data integration are playing in elucidating the complex mechanisms underlying nutrition, and provide some examples on how to extend the application of these methods using available microarray data.

show abstract

“…There are a number of reversible causes of mild cognitive impairment and early dementia (129). A Mediterranean diet with extra virgin olive oil delays the loss of cognition and may prevent Alzheimer's disease (130)(131)(132). A number of other nutritional approaches have been tried with limited success (133)(134)(135)(136).…”

Section: Editorialmentioning

confidence: 99%

Geriatrics in the 21st century

Vellas

Morley

2018

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

Abstract: A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. However, non-significant differences were found for most cognitive domains. Participants allocated to an EVOO-rich MedDiet had less MCI than controls.

Cited by 223 publications

References 52 publications

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes

Geriatrics in the 21st century

Contact Info

Product

Resources

About