Virally induced alterations in cellular permeability: A basis of cellular and physiological damage?

Pasternak, C. A.; Micklem, K. J.

doi:10.1007/bf01121577

Cited by 53 publications

(18 citation statements)

References 105 publications

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“…On the other hand, in rhinovirus or VSV-infected HeLa cells, Na-K changes clearly preceded trypan blue staining, meaning that at least in these instances Na-K changes were not a consequence but could have been a cause of loss of cell viability. These observations support the hypothesis that virus-induced permeability changes in cellular plasma membrane may be involved in the pathological effects of certain viral infections (Pasternak & Micklem, 1981).…”

supporting

confidence: 78%

Na and K Changes in Animal Virus-infected HeLa Cells

Nair

1984

Journal of General Virology

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supporting

confidence: 78%

Na and K Changes in Animal Virus-infected HeLa Cells

Nair

1984

Journal of General Virology

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“…Basically two Infection of cells with paramyxovirus induces modifications in membrane potential, and also alterations in their permeability to a number of low-molecular-weight compounds [31]. These changes occur very early in infection.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Membrane Integrity and the Inhibition of Host Translation in Virus‐Infected Mammalian Cells

Lacal

Carrasco

1982

European Journal of Biochemistry

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The inhibition of host protein synthesis after picornavirus infection, and its relationship to the modification of membrane permeability has been studied. In encephalomyocarditis (EMC)-virus-infected L cells, cellular protein synthesis is reduced from the third hour after infection, at which time an inhibition in "Rb' uptake by the infected cell was observed. The bulk of viral protein synthesis takes place in a cell in which a profound modification in the ionic concentration has occurred. This is in agreement with the idea that optimal viral translation requires a higher concentration of monovalent ions as compared to cellular protein synthesis.A parallel measurement of (a) protein synthesis, (b) "RbC content, (c) membrane potential and (d) modification of permeability to hygromycin B in EMC-virus-infected and poliovirus-infected HeLa cells, indicates that in EMC-virus-infected cells a correlation exists between membrane alterations and the inhibition of host protein synthesis. This correlation was not apparent in poliovirus-infected cells, suggesting that in this system other factors, different from monovalent ion alterations, are involved in the shut-off. However, in this system, the synthesis of viral proteins also takes place when the cell nT3nbrdne has been modified and permeability to ions is altered.The analysis of the shut-off of protein synthesis and permeability modification in different cell lines infected with EMC virus or poliovirus indicates that the kinetic pattern of the shut-off is variable and depends on the cell line used and the multiplicity of infection used in each experiment.The ATP content of picornavirus-infected cells was examined throughout infection. A decrease of this nucleotide in the infected cells was apparent from the third hour post-infection and this factor could perhaps contribute to the inhibition of viral protein synthesis that occurs late in infection. Another factor that could influence this inhibition is the transport of amino acids. For instance, the transport of glycine decreased from the beginning of the infection in EMC-virus-infected cells and a leakage of methionine was also observed late in infection. These modifications in membrane permeability could contribute to the development of the cytopathic effect observed in virus-infected cells

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“…These virus-mediated plasma membrane effects are likely to contribute to cell death in lytic infections, they may underlie perturbations of cellular functions, or promote the expression of malignant phenotypes by transformed cells (Pasternak & Micklem, 1981 ;Garry et al, 1982;Carrasco & Lacal, 1983;Lutton & Gauntt, 1986;Seth et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Tacaribe Virus Infection May Induce Inhibition of the Activity of the Host Cell Ca2+ and Na+/K+ Pumps

Rey

Rossi²,

López³

et al. 1988

Journal of General Virology

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SUMMARYInfection of Vero cells with Tacaribe virus stocks containing a high ratio of standard (plaque-forming) viruses to defective interfering particles (DIP) induced inhibition of the host cell Ca 2+ ATPase (Ca 2+ pump) and the ouabain-sensitive Na+/K + ATPase (Na+/K + pump). The Mg 2+ ATPase which is not involved in cation transport was not affected. The presence of DIP in the inocula protected the cells from alteration of the transport-associated ATPases induced by standard viruses.

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Virally induced alterations in cellular permeability: A basis of cellular and physiological damage?

Cited by 53 publications

References 105 publications

Na and K Changes in Animal Virus-infected HeLa Cells

Na and K Changes in Animal Virus-infected HeLa Cells

Relationship between Membrane Integrity and the Inhibition of Host Translation in Virus‐Infected Mammalian Cells

Tacaribe Virus Infection May Induce Inhibition of the Activity of the Host Cell Ca2+ and Na+/K+ Pumps

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