Viral haemorrhagic fever in children

MacDermott, Nathalie; De, Surya K.; Herberg, Jethro

doi:10.1136/archdischild-2014-307861

Cited by 7 publications

(6 citation statements)

References 48 publications

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“…All children <13 years of age admitted to 11 EHUs in the Western Area from August 14, 2014, through March 31, 2015, were eligible for inclusion, anticipating that the disease phenotype in adolescents might be similar to that in adults and that some factors (e.g., caregiver accompaniment) were more relevant for younger children ( 3 , 14 ). Patients were screened for EVD symptoms or contact with EBOV on entry to healthcare facilities.…”

Section: Methodsmentioning

confidence: 99%

Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Fitzgerald¹,

Naveed²,

Wing³

et al. 2016

Emerg. Infect. Dis.

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Section: Methodsmentioning

confidence: 99%

Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Fitzgerald¹,

Naveed²,

Wing³

et al. 2016

Emerg. Infect. Dis.

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“…Risk factors for acquiring the virus include residence in rural areas or communities with poor sanitation, crowded living conditions, family contacts of infected persons and health workers [2,11]. Lassa fever affects all age groups but the clinical course of paediatric Lassa fever is poorly described in literature [12]. Available evidence suggests paediatric illness presents with an acute febrile illness, generalized edema, abdominal distension, and bleeding [13].…”

Section: Discussionmentioning

confidence: 99%

Fatal case of newborn Lassa fever virus infection mimicking late onset neonatal sepsis: a case report from northern Nigeria

Ogunkunle¹,

Bello²,

Anderson³

et al. 2020

Infect Dis Poverty

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Background: Lassa fever is a zoonotic viral infection endemic to the West Africa countries. It is highly fatal during pregnancy and as such reports of neonatal onset Lassa fever infections are rare in scientific literature. We report a fatal case of Lassa fever in a 26-day-old neonate mimicking the diagnosis of late-onset neonatal sepsis. Case presentation: The patient is a 26-day-old neonate who was admitted with a day history of fever, poor feeding, pre-auricular lymphadenopathy and sudden parental death. He was initially evaluated for late onset neonatal sepsis. He later developed abnormal bleeding and multiple convulsions while on admission, prompting the need to evaluate for Lassa fever using reverse transcription polymerase chain reaction (RT-PCR). He died 31 h into admission and RT-PCR result was positive for Lassa fever. Conclusions: Neonatal Lassa fever infection is highly fatal and can mimic neonatal sepsis. High index of suspicion is needed particularly for atypical presentations of neonatal sepsis in Lassa fever endemic areas.

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“…Viral hemorrhagic fevers are highly infectious conditions characterized by fever and bleeding disorders that can progress to shock and death. VHFs are caused by different viruses from the families Flaviviridae, Bunyaviridae, Arenaviridae and Filoviridae (MacDermott et al , ). Similar to the cases of malaria, a lower platelet count is extremely common in VHFs (Zapata et al , ).…”

Section: Thrombocytopenia In Malariamentioning

confidence: 99%

Platelets and infections in the resource‐limited countries with a focus on malaria and viral haemorrhagic fevers

Thachil

2017

Br J Haematol

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SummaryInfections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required. Thrombocytopenia is one of the most common manifestations in all these infections and may be used as an easily available prognostic indicator and marker for the severity of the infections. In this review, the relevance of platelets in infections in general, and specifically to tropical infections, malaria, and viral haemorrhagic fevers in the emerging countries is discussed. Better understanding of the pathophysiology and the role of platelets in particular in such conditions is likely to translate into better patient care and thus reduce morbidity and mortality.

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Viral haemorrhagic fever in children

Cited by 7 publications

References 48 publications

Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Ebola Virus Disease in Children, Sierra Leone, 2014–2015

Fatal case of newborn Lassa fever virus infection mimicking late onset neonatal sepsis: a case report from northern Nigeria

Platelets and infections in the resource‐limited countries with a focus on malaria and viral haemorrhagic fevers

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