2017
DOI: 10.1111/bjh.14582
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Abstract: SummaryInfections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and … Show more

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Cited by 12 publications
(18 citation statements)
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References 73 publications
(86 reference statements)
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“…The negative correlation between peripheral platelets and binding intensity is interesting as thrombocytopenia has been used as a predictor for malaria (Lampah et al, 2015;Thachil, 2017) and specifically for P. falciparum SM (Gerardin et al, 2002;Cserti-Gazdewich et al, 2012). There was a correlation between the avidity of binding of CM isolates and peripheral parasitaemia and platelet counts at the time of admission of the CM cases.…”
Section: Discussionmentioning
confidence: 98%
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“…The negative correlation between peripheral platelets and binding intensity is interesting as thrombocytopenia has been used as a predictor for malaria (Lampah et al, 2015;Thachil, 2017) and specifically for P. falciparum SM (Gerardin et al, 2002;Cserti-Gazdewich et al, 2012). There was a correlation between the avidity of binding of CM isolates and peripheral parasitaemia and platelet counts at the time of admission of the CM cases.…”
Section: Discussionmentioning
confidence: 98%
“…The increased binding (at standardised assay conditions of 2% parasitaemia and 5% haematocrit) to EC correlated with increased parasitaemia, but with decreased platelet numbers. Activation of platelets and platelet consumption leads to a pro-coagulant state characterised by an increase in thrombin and von Willebrand factor, which are demonstrated in SM (Dorovini-Zis et al, 2011;O'Sullivan et al, 2016;Thachil, 2017). A recent study in children recruited from the same hospital in 2015-2016 showed that low platelet levels were also associated with retinopathy-positive CM cases and brain swelling (Kessler et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
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“…Few publications directly correlate parasitemia with lower platelet counts, and this correlation has mainly been presented in P. vivax malaria. [19][20][21] Thrombocytopenia in the absence of significant bleeding is not considered a clinical manifestation for severe malaria. 22 However, some studies correlate the levels of thrombocytopenia with malaria severity.…”
Section: Discussionmentioning
confidence: 99%