Viral Diseases of the Respiratory System

Parker, John C.; Richter, Conrad

doi:10.1016/b978-0-12-262502-2.50015-8

Cited by 20 publications

(13 citation statements)

References 166 publications

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“…Viruses lacking the ability to persist within the host were not recorded in captive-bred mice, even for pathogens known to be highly stable in the environment (e.g. MVM, MHV, Sendai virus) Laboratory Animals (2007) 41 (Parker et al 1970, Parker & Richter 1982, Barthold 1986). The failure of transmission through contamination of the environment and fomites was surprising, especially considering the highly contagious nature of several of these agents (Institute of Laboratory Animal Resources 1991).…”

Section: Discussionmentioning

confidence: 99%

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

et al. 2007

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SummaryThe serological prevalence of 13 murine viruses was surveyed among 103 wild-caught and 51 captive-bred house mice (Mus domesticus), originating from several trapping locations in northwest England, using blood samples obtained during routine health screening of an established wild mouse colony. A high proportion of recently caught wild mice were seropositive for mouse hepatitis virus (86%), mouse cytomegalovirus (79%), mouse thymic virus (78%), mouse adenovirus (68%), mouse parvovirus (59%) and minute virus of mice (41%). Seroprevalences of lymphocytic choriomeningitis virus (LCMV), orthopoxvirus, reovirus-3 and murid herpesvirus 4 (MuHV-4, also called murine g-herpesvirus [MHV-68]) were low (3-13%), and no animals were seropositive to Sendai virus, pneumonia virus or polyomavirus. Seroprevalence in wild-caught animals that had been in captivity for over six months was generally consistent with the range found in recently caught wild animals, while seroprevalence was generally much lower in captive-bred mice despite no attempt to prevent viral spread. A notable exception to this was LCMV, which appeared to have spread efficiently through the captive population (both captive-bred and wild-caught animals). Given the known viral life cycles in laboratory mice, it appears that viral persistence in the host was an important contributing factor in the spread of infection in captivity.

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Section: Discussionmentioning

confidence: 99%

Serological survey of virus infection among wild house mice (Mus domesticus) in the UK

et al. 2007

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“…Based on this information we showed that progeny free of infectious ectromelia virus can be derived from dams previously infected with the NIH-79 strain by quarantine coupled, for breeding colonies, with temporary cessation of breeding [2]. This finding suggests that mousepox epizootics can be controlled by methods used to eliminate acute viral infections [11,16], a more attractive alternative than the long established practices of mass euthanasia and vaccination [13]. Nonetheless, confidence in quarantine as a method for controlling mousepox would be increased by showing that it is effective in mice infected with a highly virulent strain of ectromelia virus.…”

Section: Introductionmentioning

confidence: 97%

Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. IV. Studies with the Moscow strain

Bhatt

Jacoby

Gras

1988

Archives of Virology

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The pathogenesis and transmission of infection with the Moscow strain of ectromelia virus were studied in inbred mice. BALB/cAnNcr had high morbidity and mortality and C57BL/6Ncr (B6) mice had high morbidity and low mortality. Virus was detected in B6 mice for 2 weeks after subcutaneous (s.c.) inoculation and infected mice developed lesions compatible with acute mousepox. B6 inoculated by footpad transmitted infection to cagemates for up to five weeks and soiled cages that had housed infected mice were infectious for three weeks. S.c.-inoculated B6 mice also transmitted by contact for 2 weeks. Transmission was attributed to oronasal excretion of virus. Airborne transmission of infection between adjacent cages occurred at a low rate. Ectromelia virus-free progeny were derived from previously infected dams. These studies indicate that the highly virulent and infectious Moscow strain of ectromelia virus caused self-limiting infection in inbred mice and that direct contact is the most efficient means of transmission. These findings support the concept that mousepox can be contained by husbandry practices that minimize or eliminate the spread of infection by direct contact or fomites.

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“…In addition, analogous procedures described for mice should be LABORATORY ANIMAL MEDICINE applicable to hamsters (Parker and Richter, 1982). Hamsters from different sources should not be housed in the same room unless all sources are known to be free of the virus.…”

Section: Sendai Virus Etiology Sendai Virus Is a Single-strandedmentioning

confidence: 99%