Biology and Diseases of Hamsters

Miedel, Emily L; Hankenson, F. Claire

doi:10.1016/b978-0-12-409527-4.00005-5

Cited by 26 publications

(9 citation statements)

References 222 publications

(199 reference statements)

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“…Cricetulus griseus, commonly known as Chinese Hamster, has a typical tendency of spontaneous diabetes (Miedel and Hankenson, 2015;Wang et al, 2019). Many lipid-related metabolisms of the hamster are more similar to that of humans than mice or rats, including HFD-induced high plasma triglycerides, VLDL and apolipoprotein (ApoB) (Song et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis

Zhang

Zhou

et al. 2020

Front. Genet.

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Zhang et al. Adipocyte Transcriptomes Change After Hypoxia 28 one-to-one lncRNA-mRNA pairs that might be closely related to adipocyte functions, such as ENSCGRT00015041780-Hilpda, TU2105-Cdsn, and TU17588-Ltbp3. These lncRNAs may represent the crucial regulation axis in the cellular response to hypoxia during adipogenesis. This study dissected the effects of hypoxia in the cell during adipogenesis, uncovered novel regulators potentially associated with WAT function, and may provide a new viewpoint for interpretation and treatment of obesity.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis

Zhang

Zhou

et al. 2020

Front. Genet.

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“…In this study, heat-killed E. faecalis T-110 decreased the total number of days of abnormal defaecation. Clostridium perfringens and C. difficile cause diarrhoea in hamsters [49]. Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…Aged hamsters often suffer from diarrhoeal infections, especially C . difficile infections [ 26 ]. These factors suggest that they are the best model of C .…”

Section: Introductionmentioning

confidence: 99%

Effects of heat-killed Enterococcus faecalis T-110 supplementation on gut immunity, gut flora, and intestinal infection in naturally aged hamsters

Inatomi

Otomaru

2020

PLoS ONE

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Infectious diseases are a threat to elderly individuals, whose immune systems weaken with age. Among the various infectious diseases, Clostridium difficile infection is associated with a high rate of mortality in elderly individuals and is a serious health problem worldwide, owing to the increasing infection rates. Probiotic use has been proposed as an effective countermeasure for C. difficile infection. The aim of this study was to evaluate the effects of heat-killed Enterococcus faecalis T-110 on intestinal immunity, intestinal flora, and intestinal infections, especially C. difficile infections, in naturally ageing animals, for extrapolating the results to elderly human subjects. Twenty female hamsters were randomly distributed into two groups. Group 1 was fed a basal diet and group 2 was fed a basal diet supplemented with heat-killed E. faecalis for 7 days. Heat-killed E. faecalis T-110 improved the gut immunity and microflora, especially Clostridium perfringens and C. difficile, in naturally aged hamsters. Therefore, heat-killed E. faecalis T-110 use may be a countermeasure against age-related immune dysfunction and intestinal infections, especially C. difficile infection, in elderly humans. However, further investigation in this regard is needed in humans.

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“…In this study, heat-killed E. faecalis T-110 decreased the total number of days of abnormal defaecation. Clostridium perfringens and C. difficile cause diarrhoea in hamsters [48].…”

Section: Total Number Of Days Of Abnormal Defaecationmentioning

confidence: 99%

Effects of heat-killed Enterococcus faecalis T-110 supplementation on gut immunity, gut flora, and intestinal infection in normal aged hamsters

Inatomi

Otomaru

2020

Preprint

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Infectious diseases are a threat to elderly people, whose immune systems become depressed with age. Among the various infectious diseases, Clostridium difficile infections in particular lead to significant mortality in elderly humans and are a serious problem worldwide, especially because of the increasing infection rates. Probiotics have been proposed as an effective countermeasure against C. difficile infection. The aim of this study was to evaluate the effects of heat-killed Enterococcus faecalis T-110 on intestinal immunity, intestinal flora, and intestinal infections, especially C. difficile infections, in naturally ageing animals, for extrapolation to elderly human subjects. Twenty female hamsters were randomly distributed into two groups. Group 1 was fed a basal diet, and group 2 was fed a basal diet supplemented with heat-killed E. faecalis for 7 days. Heat-killed E. faecalis T-110 improved gut immunity and microflora, especially Clostridium perfringens and C. difficile, of the normal aged hamsters. Heat-killed E. faecalis T-110 may, therefore, be a countermeasure against age-related immune dysfunction and intestinal infections, especially C. difficile infection, in elderly humans. However, further investigation in humans is needed.

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Biology and Diseases of Hamsters

Cited by 26 publications

References 222 publications

Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis

Comprehensive Analysis of mRNA and lncRNA Transcriptomes Reveals the Differentially Hypoxic Response of Preadipocytes During Adipogenesis

Effects of heat-killed Enterococcus faecalis T-110 supplementation on gut immunity, gut flora, and intestinal infection in naturally aged hamsters

Effects of heat-killed Enterococcus faecalis T-110 supplementation on gut immunity, gut flora, and intestinal infection in normal aged hamsters

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