Viral antigens and antibodies in hepatitis B infection.

Howard, Colin R.; Zanetti, Â.R.; Thal, S; Zuckerman, Arie J.

doi:10.1136/jcp.31.7.681

Cited by 17 publications

(3 citation statements)

References 21 publications

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“…DNAp in sera was tested by the method of Kaplan el al. [14], with few modifications [7], The specificity of DNAp was confirmed by immunoprécipitation [15]. Statistical analyses were performed using the chi-square test and Wilcoxon's rank sum test.…”

Section: Methodsmentioning

confidence: 99%

“…HBe antigen (HBe Ag) seems to be a marker of viral replication, since it strictly cor relates with Dane core-associated DNA polymerase activ ity (DNAp) [5][6][7], and its persistence after the acute phase has been proposed as an index able to predict chronicity [8] and severity of liver disease [9,10], By contrast, antiHBe is believed to indicate non-progressive liver disease, and is usually associated with normal liver histology [10], In most HBs Ag positive RDT patients, HBe Ag is present as well [4], The presence of this marker in the acute phase is associated with the development of a chronic H Bs Ag carrier state and with liver histology suggestive of chronic hepatitis leading to cirrhosis [I I], although there are conflicting results on this topic [12].…”

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confidence: 99%

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Relevance of HBe/Anti-HBe System and of DNA Polymerase Activity in Chronic Hepatitis-B Virus Carriers on Haemodialysis

Marchesini¹,

Zoli²,

Angiolini³

et al. 1981

Nephron

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To assess the relevance of HBe/anti-HBe system and DNA polymerase activity in patients on regular dialysis treatment, we prospectively studied 38 patients on haemodialysis, who were chronic carriers of HBs Ag (range 6–66 months), and 26 HBs Ag negative dialysis patients as controls. HBe Ag was present in 74%, DNA polymerase in 60%, and anti-HBe in 13% of HBs Ag positive patients. After a mean follow-up of 23.5 months, only 2 patients, who had been HBe Ag positive, had cleared HBs Ag, and 1 of them had turned to anti-HBS positivity. Among the patients who were still HBs Ag positive, only 1 had lost HBe Ag, without developing anti-HBe. Throughout the study, SGOT and SGPT levels were significantly raised in HB virus carriers as compared to controls. In the HBs Ag positive group, the presence of HBe Ag and/or DNA polymerase characterized a subgroup with the most striking abnormalities in enzyme levels. The causes of death in the HBs Ag positive group were not related to liver disease. Viral replication usually takes place in HB virus carriers on haemodialysis and is associated with biochemical evidence of liver-cell damage. However, the HB virus carrier state, and the underlying liver disease, are not major problems at present in patients on chronic haemodialysis.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Relevance of HBe/Anti-HBe System and of DNA Polymerase Activity in Chronic Hepatitis-B Virus Carriers on Haemodialysis

Marchesini¹,

Zoli²,

Angiolini³

et al. 1981

Nephron

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“…Η παρατεινόμενη παρουσία της στον ορό είναι πιο αξιόπιστος δείκτης μεταπτώσεως σε χρόνια ηπατική νόσο, απ'ότι η παραμονή του HBeAg (Alberti et al, 1979). H DNA πολυμεράση ανιχνεύεται στο 20% των υγιών αιμοδοτών φορέων του HBsAg (Howard et al, 1978).…”

Section: Dna πολυμεράσηunclassified

Συχνότητα Εμβολιασμού Κατά Της Ηπατίτιδας Β Στο Νοσηλευτικό Προσωπικό Και Παράγοντες Που Τον Καθορίζουν

Νούλα¹

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Effect of ethanol during hepatitis B virus infection in chimpanzees

Tabor

Gerety

Barker

et al. 1978

Journal of Medical Virology

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To determine whether the use of ethyl alcohol (ethanol, C2H5OH) may increase the liver damage caused by hepatitis B virus infection, ethanol was infused into four chimpanzees on one or two occasions during the course of natural or experimentally induced hepatitis B virus infections. A fifth chimpanzee, without active hepatitis B virus infection, served as a control. Moderate elevations of serum aspartate or alanine aminotransferases occurred in four of the five chimpanzees, including the control chimpanzee, in direct association with ethanol infusion; pre-existing enzyme elevations persisted in a fifth chimpanzee. No alteration occurred in the titers of hepatitis B surface antigen or of antibody to hepatitis B core antigen in three of the four infected chimpanzees. There was no significant alteration in the course of hepatitis B virus infection by ethanol infusion in these chimpanzees.

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Viral antigens and antibodies in hepatitis B infection.

Cited by 17 publications

References 21 publications

Relevance of HBe/Anti-HBe System and of DNA Polymerase Activity in Chronic Hepatitis-B Virus Carriers on Haemodialysis

Relevance of HBe/Anti-HBe System and of DNA Polymerase Activity in Chronic Hepatitis-B Virus Carriers on Haemodialysis

Συχνότητα Εμβολιασμού Κατά Της Ηπατίτιδας Β Στο Νοσηλευτικό Προσωπικό Και Παράγοντες Που Τον Καθορίζουν

Effect of ethanol during hepatitis B virus infection in chimpanzees

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