Viral Antibodies in Multiple Sclerosis

Kinnunen, Esko; Valle, M; Piirainen, Liisa; Kleemola, Marjaana; Kantanen, Marja-Leena; Juntunen, Juhani; Klockars, Matti; Koskenvuo, Markku

doi:10.1001/archneur.1990.00530070031008

Cited by 29 publications

(13 citation statements)

References 27 publications

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“…Further, a co-twin study has reported a higher frequency of anti-EBV IgG antibodies in the twins with multiple sclerosis compared with their healthy co-twins 23. Coyle et al 19 have reported a higher frequency of anti-EBV antibodies in patients with multiple sclerosis (13 of 22) compared with controls (three of 12) although the numbers were small.…”

Section: Discussionmentioning

confidence: 97%

Altered antibody pattern to Epstein-Barr virus but not to other herpesviruses in multiple sclerosis: a population based case-control study from western Norway

Myhr

Riise

Barrett‐Connor

et al. 1998

Journal of Neurology, Neurosurgery & Psychiatry

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Objective-The prevalence of anti-EBV antibodies was studied in a group of 144 patients with multiple sclerosis and 170 age, sex, and area matched controls from the county of Hordaland, western Norway. The prevalence of three other herpesviruses, herpes simplex virus (HSV), varicella zoster virus (VZV), and cytomegalovirus (CMV), were also included. Methods-Antibodies to various virus antigens were determined by enzyme linked immunosorbent assay (ELISA) and indirect immunfluorescence (IIF) in serum samples from 144 patients with multiple sclerosis and 170 controls. Results-All of the 144 patients with multiple sclerosis had IgG antibodies to EBV compared with 162 of 170 controls (p=0.008). The frequency of IgG antibodies to EBV capsid antigen (VCA), nuclear antigen (EBNA), and early antigen (EA) was significantly higher in patients with multiple sclerosis compared with the controls (p<0.000001, p=0.01, and p<0.0001 respectively). The presence of antibodies was independent of the initial course of the disease and the disease activity at the time of blood sampling. The prevalence of IgG antibodies to HSV, CMV, and VZV did not diVer between cases and controls. Conclusion-The results suggest a role for EBV in the aetiology of multiple sclerosis. (J Neurol Neurosurg Psychiatry 1998;64:539-542)

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Section: Discussionmentioning

confidence: 97%

Altered antibody pattern to Epstein-Barr virus but not to other herpesviruses in multiple sclerosis: a population based case-control study from western Norway

Myhr

Riise

Barrett‐Connor

et al. 1998

Journal of Neurology, Neurosurgery & Psychiatry

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“…It has been suggested that the continuous virus antibody production could be the result of a polyclonal activation of memory B lymphocytes 10 . As those viral antigens have not been shown in CNS, it has been proposed that the memory cells could be attracted to the CNS and then activated due to an immunologic defect 2,19 Oligoclonal bands of local origin are present in all inflammatory diseases with a humoral type immune response, including HAM/TSP, MS, neuro-SLE and several infectious brain diseases 2,3 .…”

Section: Discussionmentioning

confidence: 99%

The value of csf analysis for the differential diagnosis of HTLV-I associated myelopathy and multiple sclerosis

Puccioni-Sohler

Kitze

Felgenhauer

et al. 1995

Arq. Neuro-Psiquiatr.

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SUMMARY -Cerebrospinal fluid (CSF) and serum of 17 patients with HAM/TSP (HTLV-I associated myelopathy/ tropical spastic paraparesis), six with multiple sclerosis and six with idiopathic epilepsy (non inflammatory control) from Brazil were analysed for the presence of intrathecal synthesis of virus-specific antibodies against measles, rubella, varicella zoster virus and herpes simplex virus by enzyme-linked immunosorbent assay (ELISA). All HAM/TSP and multiple sclerosis cases had an intrathecal immune response (oligoclonal IgG). In HAM/TSP, only 1/17 case showed a polyspecific intrathecal immune response against measles and rubella virus. In multiple sclerosis, specific antibodies against measles and rubella (MRZ response) were observed in all patients but not in the control with idiopathic epilepsy. The diagnostic and theoretical relevance of mono-and polyspecific immune responses is discussed for these chronic neurological diseases. KEY WORDS: HTLV-I, HAM/TSP, cerebrospinal fluid, antibody indexValor da análise do LCR para o diagnóstico diferencial de mielopatia associada ao HTLV-I e esclerose múltipla RESUMO -Amostras de líquido cefalorraquidiano (LCR) e soro de 17 pacientes brasileiros com HAM/TSP, seis com esclerose múltipla e seis com epilepsia idiopática (controle não-inflamatório) foram analisadas para a presença de anticorpos para os vírus do sarampo, rubéola, varicela zoster e herpes simples pelo método de ELISA. Todos os casos de HAM/TSP e esclerose múltipla tinham resposta imune intratecal (IgG oligoclonal). Somente 1/17 casos de HAM/TSP apresentavam resposta imune poliespecifica intratecal para sarampo e rubéola. Anticorpos específicos para sarampo e rubeola (resposta MRZ) foram observados em todos os pacientes com esclerose múltipla, mas não nos controles com epilepsia idiopática. A relevância das respostas poliespecifica e monoespecifica é discutida para essas doenças neurológicas crônicas. PALAVRAS-CHAVE: HTLV-I, HAM/TSP, líquido cefalorraquidiano, índice de anticorpos.The sensitive detection of intrathecally synthesized antibodies increased the relevance of CSF analysis for diagnosis of neurological diseases 17 . The sucessful concepts for discrimination of blood derived and brain derived CSF fractions 16 of immunoglobulin could be extended to the detection of brain defined specific antibodies exceeding the theoretical upper concentration of blood derived antibody species in CSF. An immune response against virus antigens within the central nervous system (CNS) has been demonstrated in different neurological diseases 1 " 4 -6,7 . This reaction may be

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“…In one study, 23% of patients with MS had disproportionately high antibodies to 2 or more viruses in the spinal Xuid (Norrby et al, 1974); in another study one patient was reported who had evidence of intrathecal synthesis of antibody to 11 diVerent viruses (Salmi et al, 1983). In general, twin studies have shown higher levels in antibody in the serum or spinal Xuid of the aVected twin than of the healthy twin (Kinnunen et al, 1990).…”

Section: Serological Studiesmentioning

confidence: 99%