VIP modulates substance P-induced plasma extravasation in vivo

Khalil, Zeinab; Andrews, Paul V.; Helme, Robert D.

doi:10.1016/0014-2999(88)90809-6

Cited by 40 publications

(8 citation statements)

References 32 publications

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“…VIP induces dilation of human submandibular arteries in vitro (15) and feline nasal vessels in vivo (47,48). VIP augments the cutaneous plasma extravasation that can be induced by substance P (49).…”

Section: Methodsmentioning

confidence: 99%

Vasoactive intestinal peptide in human nasal mucosa.

Baraniuk¹,

Lundgren²,

Okayama³

et al. 1990

J. Clin. Invest.

118

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Vasoactive intestinal peptide (VIP), which is present with acetylcholine in parasympathetic nerve fibers, may have important regulatory functions in mucous membranes. The potential roles for VIP in human nasal mucosa were studied using an integrated approach. The VIP content of human nasal mucosa was determined to be 2.84±0.47 pmol/g wet weight (n = 8) by RIA. VIP-immunoreactive nerve fibers were found to be most concentrated in submucosal glands adjacent to serous and mucous cells. 125I-VIP binding sites were located on submucosal glands, epithelial cells, and arterioles. In short-term explant culture, VIP stimulated lactoferrin release from serous cells but did not stimulate [3Hjglucosamine-labeled respiratory glycoconjugate secretion. Methacholine was more potent than VIP, and methacholine stimulated both lactoferrin and respiratory glycoconjugate release. The addition of VIP plus methacholine to explants resulted in additive increases in lactoferrin release. Based upon the autoradiographic distribution of 125I.VIP binding sites and the effects on explants, VIP derived from parasympathetic nerve fibers may function in the regulation of serous cell secretion in human nasal mucosa. VIP may also participate in the regulation of vasomotor tone. (J. Clin. Invest. 1990. 86:825-831.)

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Section: Methodsmentioning

confidence: 99%

Vasoactive intestinal peptide in human nasal mucosa.

Baraniuk¹,

Lundgren²,

Okayama³

et al. 1990

J. Clin. Invest.

118

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show abstract

“…Parasympathetic neurons contain vasoactive intestinal peptide (VIP), which also may induce vasodila tation and glandular secretion [14]. SP-induced plasma extravasation is increased by VIP [15], The pathophysiological role of neuropeptides depends on the presence of peptide-positive nerve fibers in the tis sue. Therefore the aim of the present study was the immu nohistochemical comparison of SP, VIP and BFP, a Cterminal homologous octapeptide of gastrin-releasing peptide, in nasal polyps and normal nasal mucosa.…”

Section: Introductionmentioning

confidence: 99%

Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Kuhn

Arnold²

1996

ORL

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The presence of neuropeptide-containing sensory, parasympathetic and sympathetic nerves in human nasal mucosa is well established. However, information regarding the neuropeptide distribution in nasal polyps is still lacking. The aim of this study was to compare immunohistologically the presence and distribution of substance P (SP), vasoactive intestinal peptide (VIP) and bombesin-flanking peptide (BFP) in normal nasal mucosa and nasal polyps. The expression was studied using Formalin-fixed and paraffin-embedded biopsy sections from 20 patients with nasal polyps and 10 controls with normal nasal mucosa from the anterior part of the inferior turbinate. Indirect immunohistochemistry (APAAP method) with mono- and polyclonal antibodies was used. None of the control group but 5 patients of the nasal polyp group had an atopic disease. Comparing localization and intensity of the immunohistological reaction in nasal mucosa and nasal polyp tissue, there was no difference in the expression of the three neuroendocrine substances. There was no difference of expression in the polyposis group itself concerning allergic and nonallergic subjects. The results indicate that VIP, SP and BFP have an equal distribution in nasal polyps and normal nasal mucosa.

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“…Similarly to PACAP, maxadilan and VIP were also shown to trigger plasma leakage in intact tissues, implicating that in the absence of mustard oil stimulation, activation of both PAC1 and VPAC1/2 receptors is associated with increased vascular permeability (Inoue et al, 1993;Khalil et al, 1988;Svensj€ o et al, 2009Svensj€ o et al, , 2012. In an other study, Ro-24-99-81, a stable analogue of VIP, facilitated the vascular permeability induced by SP and capsaicin, while VIP had no effect (Gao et al, 1995).…”

Section: Discussionmentioning

confidence: 91%