“…Similarly to PACAP, maxadilan and VIP were also shown to trigger plasma leakage in intact tissues, implicating that in the absence of mustard oil stimulation, activation of both PAC1 and VPAC1/2 receptors is associated with increased vascular permeability (Inoue et al, 1993;Khalil et al, 1988;Svensj€ o et al, 2009Svensj€ o et al, , 2012. In an other study, Ro-24-99-81, a stable analogue of VIP, facilitated the vascular permeability induced by SP and capsaicin, while VIP had no effect (Gao et al, 1995).…”