Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Kuhn, Annette; Arnold, William H.

doi:10.1159/000276842

Cited by 5 publications

(6 citation statements)

References 14 publications

(18 reference statements)

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“… 21 The results of an immunohistochemical study by Kühn and Arnold indicated that substance P have an equal distribution in NPs and healthy nalas mucosa. 22 Our results, however, suggest higher level of substance P production in patients with NP than in subjects without nasal inflammation. We found no statistical difference between substance P levels in NANP and ANP, suggesting that this neuropeptide maybe has not a crucial role in the pathogenesis of “allergic” form of NPs.…”

Section: Discussioncontrasting

confidence: 65%

“…As the main neuropeptide in the nasal mucosa, substance P has been reported to induce vasodilatation, vascular permeability and mucus secretion 21 . The results of an immunohistochemical study by Kühn and Arnold indicated that substance P have an equal distribution in NPs and healthy nalas mucosa 22 . Our results, however, suggest higher level of substance P production in patients with NP than in subjects without nasal inflammation.…”

Section: Discussioncontrasting

confidence: 49%

See 1 more Smart Citation

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Dimić

Perić

Grgurević

et al. 2022

Laryngoscope Investig Oto

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Objectives: Biomarker levels in nasal secretions can reflect the inflammatory status of nasal mucosa and evolution of sinus disease. The aim of this study was to evaluate the relationship between local inflammatory mediator production and clinical characteristics of patients with nasal polyposis (NP).Methods: Thirty-one nonaeroallergen sensitized patients with NP (NANP), 29 aeroallergen sensitized patients with NP (ANP), and 30 subjects without inflammation of nasal mucosa as controls (C) entered this prospective, cross-sectional study.Clinical parameters (symptoms, endoscopic, and radiological findings) were assessed.The concentrations of heat shock protein 70 (HSP70), eosinophil cationic protein (ECP), tryptase, substance P and Clara cell protein 16 (CC16) were measured in the nasal secretion samples of all participants by ELISA method.Results: Our results showed higher concentrations of HSP70, ECP, and tryptase in ANP than in NANP and C (p < .001 for all markers). On the other hand, levels of CC16 were significantly higher in C than in NANP and ANP groups (p < .001; p < .001, respectively). We found positive correlations between HSP70, ECP, tryptase, and substance P levels and nasal symptom score in patients with NP. Also, HSP70, ECP, tryptase, and substance P showed different levels of positive correlation among themselves, with HSP70 showing highest positive correlation with ECP.Finally, relatively strong negative correlations were found between the levels of CC16 and nasal symptoms, as well as between the CC16 levels and levels of other four mediators in nasal fluid.Conclusion: HSP70, ECP, tryptase, and substance P might play a role in the pathogenesis of NP. The results suggest that chronic inflammation in NP involves a selfsustaining local release of HSP70, ECP, and tryptase, independent of aeroallergen stimulation of the mucosal layer, although the production of these mediators is higher in aeroallergen sensitized NP patients.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussioncontrasting

confidence: 49%

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Dimić

Perić

Grgurević

et al. 2022

Laryngoscope Investig Oto

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“…Elevated concentrations of substance P were found by Drake‐Lee et al ( 69); these findings were not confirmed in other publications ( 70).…”

Section: Other Mediatorsmentioning

confidence: 65%

Nasal polyposis: eosinophils and interleukin‐5

Krämer

Rasp

1999

Allergy

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“…However, neurogenic inflammation was demonstrated following capsaicin application to the nasal polyp tissue of non-allergic patients with nasal polyposis (12). The presence of neurokinins in the nasal polyps was established, but their role in pathogenesis remains unclear (17).…”

Section: Resultsmentioning

confidence: 99%

Capsaicin Significantly Reduces Sinonasal Polyps

Baudoin

2000

Acta Oto-Laryngologica

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Some reports indicate that topical nasal treatment with capsaicin, which is usually effective in reducing symptoms of vasomotor rhinitis, may also reduce symptoms in patients with nasal polyps. The aim of this study was to investigate the effect of topical capsaicin treatment in severe sinonasal polyposis. Nine non-allergic, non-asthmatic patients with diffuse eosinophilic nasal polyposis were subjected to topical capsaicin treatment: for 3 consecutive days 0.5 ml 30 micromol/l capsaicin solution and on days 4 and 5 100 micromol/l capsaicin solution was sprayed into each nostril. Coronary computed tomography (CT) images were made shortly before treatment. Baseline nasal lavages and a questionnaire containing subjective symptoms and nasal endosocpy were taken just prior to the first application. Nasal lavages were performed prior to and after the last treatment and over 4 weeks, endoscopy and subjective scores at each weekly visit, and correspondent CT scans 4 weeks after the treatment. CT images were analysed by computer, calculating the nose sinuses air volume (NSAV) from the surface of aerated parts of nasal and sinus cavities for each slice per patient prior to and after treatment. Statistical analysis was performed comparing NSAV, subjective scores, endoscopy scores and eosinophil cationic protein (ECP) levels in nasal lavages prior to and after treatment. Topical treatment with capsaicin significantly increased NSAV and very significantly improved subjective and endoscopy scores, but did not significantly alter ECP levels in nasal lavages.

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Expression of Vasoactive Intestinal Peptide, Substance P and Bombesin-Flanking Peptide in Nasal Polyps

Cited by 5 publications

References 14 publications

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Different levels of mucus inflammatory mediators in nasal polyposis with and without aeroallergen sensitivity

Nasal polyposis: eosinophils and interleukin‐5

Capsaicin Significantly Reduces Sinonasal Polyps

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