Violides N-P, New Briarane Diterpenes from a Gorgonacean Briareum Sp.

Iwagawa, Tetsuo; Hirose, Tetsushi; Takayama, Keita; Okamura, Hiroaki; Nakatani, Munehiro; Doe, Matsumi; Takemura, Kentaro

doi:10.3987/com-00-8921

Cited by 13 publications

(12 citation statements)

References 4 publications

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“…42 Investigation of bioactive metabolites from a Briareum sp. collected in the area of Bonotsu, Kogoshima Prefecture, has led to the isolation of the briaranetype diterpenoids violides C-V (155)(156)(157)(158)(159)(160)(161)(162)(163)(164)(165)(166)(167)(168)(169)(170)(171)(172)(173)(174) and five new structures related to the violides (175-179), [43][44][45][46][47] their structures being elucidated by interpretation of spectroscopic and X-ray crystallographic data. Some of these metabolites exhibited moderate cytotoxicity against the growth of Vero and MDCK cells.…”

Section: Family Briareidaementioning

confidence: 99%

Diterpenes from gorgonian corals

2009

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Covering: 1995 to April 2008. Gorgonian corals continue to provide a wealth of novel structures, many of which exhibit potentially useful biological activity. Notably, the families Briareidae, Gorgoniidae and Plexauridae have been demonstrated to contain a wide variety of natural products including steroids, acetogenins, sesquiterpenes and diterpenes. The most common of the gorgonian natural products are the diterpenes, and the intent of this review is to describe such compounds isolated from gorgonian corals, with a focus on the structures of new compounds as well as their biological activity. There have been developments improving our understanding of the biosynthetic origin of selected diterpenes, and these will also be discussed. This review describes 602 new compounds from 177 articles.

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Section: Family Briareidaementioning

confidence: 99%

Diterpenes from gorgonian corals

2009

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“…has yielded three additional briaranes, violides N-P of which violide N 664 exhibited moderate cytotoxicity. 441 Junceellolides E-G 667-669 are additional briaranes from the gorgonian Junceella fragilis from Taiwan. 442 The gorgonian Erythropodium caribaeorum from several sites in the Southern Caribbean contained the known microtubule stabilizing compound eleutherobin 670, which had previously been isolated from a rare Eleutherobia sp.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

2001

Nat. Prod. Rep.

398

128

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This review covers the marine natural products literature for the year 2000 and is organized phylogenetically, with sections on marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates. echinoderms and miscellaneous marine organisms. There is an emphasis on new structures, stressing their biological activities, source organisms and countries of origin, and also syntheses that confirm the structures of known compounds. The review contains 869 structures and 592 references, of which 434 appeared between January and December 2000.

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“…They established the structures, including the relative configurations, of briaranes 42 – 45 by interpretation of spectroscopic data, and determined the absolute configurations of brianodins C ( 44 ) and D ( 45 ) by the modified Mosher’s method ( Figure 10 ). The 1,2-diol moiety at C-8 and C-17 in 43 – 45 is rarely found in briarane analogues [ 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Briaranes From Pachyclavularia Sp Andmentioning

confidence: 99%

Terpenoids from Octocorals of the Genus Pachyclavularia

Chang

Sheu

et al. 2017

Marine Drugs

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In this paper, we reviewed natural compounds isolated from octocorals belonging to the genus Pachyclavularia, including 20 cembrane-, 39 briarane-, and eight briarellin-related diterpenoids, and one secosterol. The chemical constituents of these 68 secondary metabolites, and their names, structures, and bioactivities, along with studies of their biological activities, are summarized in this review. Based on the literature, many of these compounds possess bioactivities, including anti-inflammation properties, cytotoxicity, and ichthyotoxicity, suggesting that they may have the potential to be developed into biomedical agents for treatment.

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Violides N-P, New Briarane Diterpenes from a Gorgonacean Briareum Sp.

Cited by 13 publications

References 4 publications

Diterpenes from gorgonian corals

Diterpenes from gorgonian corals

Marine natural products

Terpenoids from Octocorals of the Genus Pachyclavularia

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