Violacein-Producing Collimonas sp. from the Sea Surface Microlayer of Costal Waters in Trøndelag, Norway

Hakvåg, Sigrid; Fjærvik, Espen; Klinkenberg, Geir; Borgos, Sven Even F.; Josefsen, Kjell D.; Ellingsen, Trond E.; Zotchev, Sergey B.

doi:10.3390/md7040576

Cited by 73 publications

(48 citation statements)

References 30 publications

(36 reference statements)

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“…It is noteworthy, that the closely related and sequenced janthinobacterial strains Marseille and GC3 did not appear to encode a functional violacein operon. Violacein is a bisindole and its biosynthesis has been observed in a wide range of different bacterial genera including Janthinobacterium , Chromobacterium [1], Collimonas [69], Pseudomonas [70], Pseudoalteromonas [71] and Duganella [72]. The violacein biosynthesis has been studied in the model organism C. violaceum in much detail [73]–[76].…”

Section: Resultsmentioning

confidence: 99%

The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases

et al. 2013

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Janthinobacteria commonly form biofilms on eukaryotic hosts and are known to synthesize antibacterial and antifungal compounds. Janthinobacterium sp. HH01 was recently isolated from an aquatic environment and its genome sequence was established. The genome consists of a single chromosome and reveals a size of 7.10 Mb, being the largest janthinobacterial genome so far known. Approximately 80% of the 5,980 coding sequences (CDSs) present in the HH01 genome could be assigned putative functions. The genome encodes a wealth of secretory functions and several large clusters for polyketide biosynthesis. HH01 also encodes a remarkable number of proteins involved in resistance to drugs or heavy metals. Interestingly, the genome of HH01 apparently lacks the N-acylhomoserine lactone (AHL)-dependent signaling system and the AI-2-dependent quorum sensing regulatory circuit. Instead it encodes a homologue of the Legionella- and Vibrio-like autoinducer (lqsA/cqsA) synthase gene which we designated jqsA. The jqsA gene is linked to a cognate sensor kinase (jqsS) which is flanked by the response regulator jqsR. Here we show that a jqsA deletion has strong impact on the violacein biosynthesis in Janthinobacterium sp. HH01 and that a jqsA deletion mutant can be functionally complemented with the V. cholerae cqsA and the L. pneumophila lqsA genes.

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Section: Resultsmentioning

confidence: 99%

The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases

et al. 2013

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“…The genes vioA and vioB were amplified by PCR from the Collimonas CT genome and sequenced showing a relationship of the Collimonas VIO biosynthetic gene cluster to those in J. lividum and Duganella sp., indicating a possible horizontal gene transfer (Hakvag et al 2009). …”

Section: Pathways Of Violacein Biosynthesismentioning

confidence: 98%

Chromobacterium violaceum and its important metabolites — review

2010

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C. violaceum appeared as important bacterium in different applications and mainly these aspects are related to the production of violacein. This review discusses the last reports on biosynthetic pathways, production, genetic aspects, biological activities, pathological effects, antipathogenic screening through quorum sensing, environmental effects and the products of C. violaceum with industrial interest. An important discussion is on biological applications in medicine and as industrial products such as textile and in cosmetics.

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“…Some of the known violacein producing organisms include Chromobacterium violaceum [2], Collimonas sp. [3], Duganella sp. [4], Janthinobacterium lividum [5,6], and Pseudoalteromonas sp.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Cytotoxic Effect of Violacein Produced by Novel Isolate Chromobacterium Vaccinii Cv5 Against the Cervical and Lung Cancer Cell

Santhosh

Palaniswamy

2017

Asian J Pharm Clin Res

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Objectives: This study investigates the in vitro anticancer activity of the violacein extracted from the Chromobacterium vaccinii CV5.Methods: Natural colorants or dyes derived from flora to fauna are believed to be safe because of nontoxic, noncarcinogenic, and biodegradable in nature. There are a number of natural pigments, but only a few are available in sufficient quantities for industrial production. The cytotoxicity activity of pigment was assessed against the cervical (HeLa) and lung cancer (A549) cell lines using the MTT assay and there by potential cytotoxic activity exhibited by the pigment was identified. Results:The result of the pigment shows potent anticancer activity on the two cancer cell lines tested in a concentration dependent manner. The potent anticancer activity was observed with the pigment with IC 50 values of 26 µg/mL on HeLa and 31 µg/mL on A549 cells, respectively. Conclusion:The study is pioneering report for determining the better in vitro anticancer activity of violacein from the novel isolate C. vaccinii CV5.

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Violacein-Producing Collimonas sp. from the Sea Surface Microlayer of Costal Waters in Trøndelag, Norway

Cited by 73 publications

References 30 publications

The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases

The Janthinobacterium sp. HH01 Genome Encodes a Homologue of the V. cholerae CqsA and L. pneumophila LqsA Autoinducer Synthases

Chromobacterium violaceum and its important metabolites — review

Evaluation of in Vitro Cytotoxic Effect of Violacein Produced by Novel Isolate Chromobacterium Vaccinii Cv5 Against the Cervical and Lung Cancer Cell

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