Vinylbenzyl quaternary ammonium-based polymeric monolith with hydrophilic interaction/strong anion exchange mixed-mode for pressurized capillary electrochromatography

Quinine‐modified polymer monolithic column with reversed‐phase /strong anion‐exchange mixed‐mode for pressurized capillary electrochromatography

“…As shown in Table , the optimal recipe was gained as column B with the obvious EOF, suitable permeability, and high column efficiency (1.17 × 10 5 plates/m). Compared with the mixed‐mode monolithic columns with SAX interaction , the column efficiency of this obtained quinine‐modified monolith was in a similar level as that of previous reports (1.0 × 10 5 ∼1.9 × 10 5 plates/m). SEM morphologies of the resultant monoliths were also measured and homogenous porous structures were clearly observed in GMA‐based parent monolith (Supporting Information Fig.…”

Recent advances in nonpolar and polar organic monoliths for HPLC and CEC

“…Porous organic polymer monolithic columns have been used extensively as HILIC stationary phases during the last few years due to their distinct advantages including (i) high permeability which leads to lower backpressure, (ii) low resistance to mass transfer, (iii) simple preparation procedure and ease of surface functionalization, (iv) stability under extreme pH conditions, and (v) a wide selection of functional monomers [43, 45]. A variety of organic polymer monoliths with amino [46, 47], amide [48], hydroxyl [48], sulfoalkylbetaine [43, 49], boronic acid [50], and some other functionalities have been reported for use in HILIC/HI-CEC separations.…”

“…Lin et al have developed a HILIC monolith using vinylbenzyl trimethylammonium chloride (VBTA) as the functional monomer, bisphenol A glycerolate dimethacrylate (BisGMA) as the crosslinker and methanol plus dodecanol as the porogenic solvents [47]. BisGMA, acting as a polar crosslinking dimethacrylate for polymeric monoliths, is superior to other dimethacrylate crosslinkers due to its relatively high molecular weight and stiff partial aromatic molecular structure, providing low polymerization shrinkage, low volatility and outstanding mechanical properties for the polymeric monolith.…”

“…BisGMA, acting as a polar crosslinking dimethacrylate for polymeric monoliths, is superior to other dimethacrylate crosslinkers due to its relatively high molecular weight and stiff partial aromatic molecular structure, providing low polymerization shrinkage, low volatility and outstanding mechanical properties for the polymeric monolith. BisGMA contains multiple polar hydroxyl and ester groups, which can give hydrophilic backbone to the polymeric monolith [47]. Ammonium groups in VBTA functional monomer afforded strong electrostatic interaction, and vinylbenzyl group with rigid phenyl framework could be employed to fabricate a stable polymeric structure.…”

Postpolymerization modification of a hydroxy monolith precursor. Part III. Activation of poly(hydroxyethyl methacrylate‐co‐pentaerythritol triacrylate) monolith with epoxy functionalities followed by bonding of glycerol, polyamines, and hydroxypropyl‐β‐cyclodextrin for hydrophilic interaction and chiral capillary electrochromatography

“…Thus, hydrophilic interaction CEC (HI‐CEC) is a perfect match for the separation of very polar and moderately polar solutes. Many organic polymer monoliths with cationic and anionic surfaces have been introduced along with some neutral monoliths for HI‐CEC, and the progress made in the field has been reviewed recently in .…”