Recent advances in nonpolar and polar organic monoliths for HPLC and CEC

Abstract

This article is aimed at providing a review of the progress made in the field over the period 2011 to present in order to expand in parts on two previous reviews (S. Karenga and Z. El Rassi, Electrophoresis, 2011, 32, 90-104; D. Gunasena and Z. El Rassi, Electrophoresis, 2012, 33, 251-261). In brief, this review article describes progress made in nonpolar and polar monoliths used in reversed phase HPLC and CEC (RPC/RP-CEC) and in hydrophilic interaction liquid chromatography/CEC (HILIC/HI-CEC), respectively. This article is by no means an exhaustive review of the literature; it is rather a survey of the recent progress made in the field with 69 references published on nonpolar and polar polymeric monoliths.

Comparison of commercial organic polymer‐based and silica‐based monolithic columns using mixtures of analytes differing in size and chemistry

“…Detailed description of progress in the field of monoliths can be found in numerous review articles and books, e.g. .…”

Postpolymerization modification of a hydroxy monolith precursor. Part I. Epoxy alkane and octadecyl isocyanate modified poly (hydroxyethyl methacrylate‐co‐pentaerythritol triacrylate) monolithic capillary columns for reversed‐phase capillary electrochromatography

“…CEC with monolithic columns has progressed enormously over the last 15 years, and the field has been summarized in typical reviews . This has been facilitated by the many sound features of monoliths including, and not limited to, ease of fabrication, good permeability, fast mass transfer, high stability, ease of modification, and the ability to optimize monolith’ porosity.…”

“…As an alternative route for monolithic column preparation, postpolymerization functionalization of precursor monoliths allows the introduction of various kinds of ligands onto the monolithic surface starting from one generic template monolith. Typical review articles summarizing some of the most recent post polymerization modification is given in . It should be mentioned that postpolymerization modification date back to the work published by Ericson et al.…”

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

“…Attractive alternatives to the classical CEC columns packed with particulate materials are the monolithic stationary phases . Their advantages are simplicity of their in situ preparation and variety of readily available chemistries for synthesis of monolithic materials.…”