Vincristine Induced Unilateral Ptosis

Škorić, Dejan; Dragana, Bogićević; Ivana, Petronić; Borivoje, Babić; Petrović, Milovan

doi:10.1097/mph.0b013e3181a7153e

Cited by 14 publications

(6 citation statements)

References 5 publications

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“…On literature review, bilateral ptosis was the most common feature of VCR‐induced cranial neuropathy and unilateral ptosis has also been reported …”

Section: Discussionmentioning

confidence: 98%

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Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement

Nazir

Futaisi

Zacharia

et al. 2017

Pediatric Blood & Cancer

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Peripheral neuropathy was the commonest form of VCR-related neuropathy. Autonomic neuropathy was relatively common in our patients. Cranial neuropathy is a serious side effect of VCR that can be severe, involving multiple cranial nerves and needs prompt recognition and management. Concomitant administration of pyridoxine and pyridostigmine does not seem to protect against further neurological damage in some patients.

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“…On literature review, bilateral ptosis was the most common feature of VCR‐induced cranial neuropathy and unilateral ptosis has also been reported …”

Section: Discussionmentioning

confidence: 98%

“…On literature review, bilateral ptosis was the most common feature of VCR-induced cranial neuropathy 1,17,21 and unilateral ptosis has also been reported. 22,23 Vocal cord paralysis can be life threatening and requires active airway management. Several authors reported many cases of vocal cord paralysis, the youngest being 5-month-old.…”

Section: Discussionmentioning

confidence: 99%

Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement

Nazir

Futaisi

Zacharia

et al. 2017

Pediatric Blood & Cancer

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“…2 Acetylcholinesterase inhibitors, such as pyridostigmine have not been used for VCR-induced neurologic symptoms, but reduction of gastrointestinal motility represents one of the major symptoms of VCRinduced neuropathy 2 It has also been reported that pyridostigmine stimulates the colonic smooth muscle. 2,8,9 In all of these reported patients, treatment was well tolerated and no side effect was documented. Recently, several authors reported full recovery of VCR-induced polyneuropathy after treatment with the usual dose of pyridoxine and pyridostigmine.…”

Section: Discussionmentioning

confidence: 79%

Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

et al. 2010

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Four children with vincristine (VCR)-induced neuropathy are being reported. All cases were followed with the diagnosis of acute lymphoblastic leukemia. Two were boys aged between 2 and 13 year. Electromyographic examination consisted of sensoriomotor polyneuropathy with axonal involvement in three patients. In another patient, it consisted of motor axonal polyneuropathy. In all patients, pyridoxine and pyridostigmine were successfully used in the treatment of VCR-induced neuropathy. They recovered completely with this drug combination. Recovering period of symptoms was between 1-2 week.

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“…Four patients developed unilateral ptosis. Three of them resolved following pyridoxine and pyridostigmine treatment [ 1 - 3 ]. Including our case, four patients were reported to develop bilateral ptosis alone without other neuropathy [ 4 - 6 ].…”

Section: Discussionmentioning

confidence: 99%

Combination of Pyridoxine and Thiamine Treatment in Bilateral Induced Ptosis in a Child - Case Report and Review of Literature

Chai¹,

Norsarwany²,

Shatriah³

2017

Cureus

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Ptosis is a rare side effect of vincristine chemotherapy in patients treated for cancer. We report a case of a child with common B-cell acute lymphoblastic leukemia who developed bilateral moderate ptosis following the chemotherapy protocol of the United Kingdom Acute Lymphoblastic Leukemia (ALL) regimen A. The patient showed dramatic clinical improvement after a combination of oral pyridoxine and thiamine treatment. We provide a literature review of this uncommon presentation.

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Vincristine Induced Unilateral Ptosis

Cited by 14 publications

References 5 publications

Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement

Vincristine‐induced neuropathy in pediatric patients with acute lymphoblastic leukemia in Oman: Frequent autonomic and more severe cranial nerve involvement

Use of pyridoxine and pyridostigmine in children with vincristine-induced neuropathy

Combination of Pyridoxine and Thiamine Treatment in Bilateral Induced Ptosis in a Child - Case Report and Review of Literature

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