Combination of Pyridoxine and Thiamine Treatment in Bilateral Induced Ptosis in a Child - Case Report and Review of Literature

Abstract

Ptosis is a rare side effect of vincristine chemotherapy in patients treated for cancer. We report a case of a child with common B-cell acute lymphoblastic leukemia who developed bilateral moderate ptosis following the chemotherapy protocol of the United Kingdom Acute Lymphoblastic Leukemia (ALL) regimen A. The patient showed dramatic clinical improvement after a combination of oral pyridoxine and thiamine treatment. We provide a literature review of this uncommon presentation.

Unilateral Ptosis in a Child with Wilm’s Tumor Induced by Vincristine

“…This reduces the rate of cell divisions thereby inhibiting tumor growth. Meanwhile, this causes the microtubules to lose function in the maintenance of cell shape and scaffolding, causing axonopathy through axonal transport impairment, and eventually leading to axonal degeneration and death [11]. Vincristine neurotoxicity is related to the dosage and frequency of administration.…”