Vinblastine, an anticancer drug, causes constipation and oxidative stress as well as others disruptions in intestinal tract in rat

Rtibi, Kaïs; Grami, Dhekra; Selmi, Slimen; Amri, Mohamed; Sebaï, Hichem; Marzouki, Lamjed

doi:10.1016/j.toxrep.2017.04.006

Cited by 36 publications

(28 citation statements)

References 25 publications

(26 reference statements)

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“…This mechanism was evaluated by lipid peroxidation, protein oxidation, and damaging actions on sulfhydryl groups. Disorders in the normal redox state of cells can induce toxic activities through the generation of free radical reactive oxygen species that induce cell injury and alter these cellular macromolecules [14]. These obtained results are in agreement with those found by Li et al [15] who revealed that the level of MDA augmented in constipated rats.…”

Section: Oxidative Stress and Constipationsupporting

confidence: 91%

Role of Oxidative/Nitrosative Stress in Diarrhea and Constipation

Rtibi¹,

Sebaï²,

Marzouki³

2018

Novel Prospects in Oxidative and Nitrosative Stress

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Oxidative/nitrosative stress, a pervasive condition of increased amounts of reactive and nitrogen species, is responsible for a variety of degenerative processes in some human diseases such as gastrointestinal affections. Diarrhea is one such infection that has long been recognized as one of the most important health problems in developing countries. Constipation is a delay or difficulty in evacuating the stool. In this respect, several studies were performed and have shown that the diarrhea pathophysiology and constipation were accompanied by accumulation of biomarkers of oxidative/nitrosative stress as well as the depletion of antioxidant system. In this chapter, we discuss about the recent advances that propose a major role of oxidative/nitrosative stress on diarrhea pathogenesis and constipation.

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Section: Oxidative Stress and Constipationsupporting

confidence: 91%

Role of Oxidative/Nitrosative Stress in Diarrhea and Constipation

Rtibi¹,

Sebaï²,

Marzouki³

2018

Novel Prospects in Oxidative and Nitrosative Stress

Self Cite

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“…Although hydrogen peroxide is still harmful to the body, CAT can degrade it into water. SOD and CAT will form into an oxidation resistant chain to remit the damage to the intestinal tract that is caused by constipation [31]. The results of our study indicate that LP-CQPC10 could effectively remit the reduced activity of Cu/Zn-SOD, Mn-SOD, and CAT caused by constipation.…”

Section: Discussionmentioning

confidence: 70%

Preventive Effect of Lactobacillus Plantarum CQPC10 on Activated Carbon Induced Constipation in Institute of Cancer Research (ICR) Mice

Zhang

Zhou

Chen³

et al. 2018

Applied Sciences

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Chinese Paocai is a traditional fermented food containing an abundance of beneficial microorganisms. In this study, the microorganisms in Szechwan Paocai were isolated and identified, and a strain of lactic acid bacteria (Lactobacillus plantarum CQPC10, LP-CQPC10) was found to exert an inhibitory effect on constipation. Microorganisms were isolated and identified via 16S rDNA. Activated carbon was used to induce constipation in a mouse model and the inhibitory effect of LP-CQPC10 on this induced constipation was investigated via both pathological sections and qPCR (quantitative polymerase chain reaction). A strain of Lactobacillus plantarum was identified and named LP-CQPC10. The obtained results showed that, as compared to the control group, LP-CQPC10 significantly inhibited the amount, weight, and water content of faeces. The defecation time of the first tarry stool was significantly shorter in LP-CQPC10 groups than in the control group. The activated carbon progradation rate was significantly higher when compared to the control group and the effectiveness was improved. LP-CQPC10 increased the serum levels of MTL (motilin), Gas (gastrin), ET (endothelin), AchE (acetylcholinesterase), SP (substance P), and VIP (vasoactive intestinal peptide), while decreasing the SS (somatostatin) level. Furthermore, it improved the GSH (glutathione) level and decreased the MPO (myeloperoxidase), MDA (malondialdehyde), and NO (nitric oxide) levels. The results of qPCR indicated that LP-CQPC10 significantly up-regulated the mRNA expression levels of c-Kit, SCF (stem cell factor), GDNF (glial cell-derived neurotrophic factor), eNOS (endothelial nitric oxide synthase), nNOS (neuronal nitric oxide synthase), and AQP3 (aquaporin-3), while down-regulating the expression levels of TRPV1 (transient receptor potential cation channel subfamily V member 1), iNOS (inducible nitric oxide synthase), and AQP9 (aquaporin-9). LP-CQPC10 showed a good inhibitory effect on experimentally induced constipation, and the obtained effectiveness is superior to that of Lactobacillus bulgaricus, indicating the better probiotic potential of this strain.

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“…Acute UG diagnosis was evaluated by different clinical signs, such as gastric juice volume, ulcer score and gastric pH. Colonic alterations were caused in vivo according to the method elucidated by Rtibi et al 18 Briey, animals were intoxicated with intravenous injection of vinblastine (2 mg kg À1 of body weight in a saline solution) for 7 days. Diagnosis of VINB injuries was conrmed by several signs, such as fecal pellet, wet fecal weight, dry fecal weight and water content.…”

Section: Animalsmentioning

confidence: 99%