The potential of <i>Thymus vulgaris</i> aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

Rtibi, Kaïs; Selmi, Slimen; Wannes, Dalanda; Jridi, Mourad; Marzouki, Lamjed; Sebaï, Hichem

doi:10.1039/c9ra02042j

Cited by 6 publications

(5 citation statements)

References 49 publications

(47 reference statements)

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“…Our results revealed that thyme composition comprises phenolic components including gallic acid, 4-amino benzoic acid, protocatchuic acid, chlorogenic acid, catechol, vanillic acid, p-coumaric acid, isoferulic acid, αcoumaric acid, 3, 4, 5 methoxycinammic, coumarin, and cinammic acid with concentration ranging from 10 to 100 ppm. This is consistent with the findings of Varga et al [40], Köksal et al [41], El-Newary et al [42], and Rtibi et al [43] who reported that typical thyme constituents included pyrogallol, caffic acid, ferulic acid, and benzoic acid. Furthermore, thyme __________________________________________________________________________________________________________________ ________________________________________________ Egypt.…”

Section: Determination Of Phenolic and Flavonoid Components Of Dry Thyme Powdersupporting

confidence: 92%

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Hepatoprotective activities of thyme (Thymus vulgaris L.) in rats suffering from obesity.

2020

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Thyme (Thymus vulgaris L.) is medicinal plant in the lamiaceae family which is cultivated worldwide for cosmetic, culinary and medical uses. The current study aimed to investigate the impact of thyme on the nutritional parameters of obese rats. Phenolic and flavonoid components were detected in dry thyme powder by HPLC-UV and thyme essential oil was analyzed by GC-MS. In the biological experiment, the study included 30 male rats of weight approximately 200 grams which were divided into 5 groups; each group comprising 6 rats. Group (G1) rats were fed on basal diet, serving as a negative control group (N-control), while group (G2) rats were fed on a high-fat diet (fat percentage 15%) (P-control).The same diet used in (G2) was given to group (G3) but along with orlistat supplementation (2mg/Kg BW rat/day) using a stomach tube. Similarly, the rats of groups (G4 and G5) received HFD and supplemented with thyme powder (3g/100g diet) and thyme essential oil (0.6g/100g fat), respectively. The obtained results indicated that, dry thyme powder composition included high concentration of phenolic compounds such as ellagic acid and salicylic acid, as well as high concentration of flavonoids was hesperidin. The major constituent of thyme essential oil was thymol. After 8 weeks, the rats fed on HFD and supplemented with different treatments (G3, G4, and G5) showed a significant decrement in glucose levels. In addition, the treatments also showed significantly enhanced lipid profiles, liver functions, and total antioxidant capacity. However, the activities of catalase and glutathione reduced were significantly elevated in the blood of thyme powder and essential oil-treated groups. Moreover, malondialdehyde was significantly decreased in the treated groups. The induction of redox enzymes serves as a dependable marker for assessing the antiperoxidative effect of herbs; hence, this study revealed the role of thyme powder and essential oil treatment in the reduction of histopathological and liver abnormalities associated with obesity.

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Section: Determination Of Phenolic and Flavonoid Components Of Dry Thyme Powdersupporting

confidence: 92%

“…63, No. 11 (2020) composition includes high concentration of some other compounds such as catechin, caffeine, p-OH benzoic, ellagic acid, and salicylic acid [42,43,44]. Meanwhile, hesperidin was high concentration in flavonoid.…”

Section: Determination Of Phenolic and Flavonoid Components Of Dry Thyme Powdermentioning

confidence: 99%

Hepatoprotective activities of thyme (Thymus vulgaris L.) in rats suffering from obesity.

2020

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“…Among the 12 components, protocatechuic acid, chlorogenic acid, rutin and isoquercetin showed promising pharmacological activities in constipation (Rtibi et al. 2019 ), smooth muscle-relaxing (Tóth et al. 2015 ) and anti-inflammatory (Ezenyi et al.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Liu-ping

Xie

Xuan

et al. 2022

Pharmaceutical Biology

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Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications. Objective To investigate the therapeutic effect of B. ceiba flower aqueous extracts (BCE) against loperamide-induced constipation and characterize the chemical composition of BCE. Materials and methods Sixty male Kunming mice were divided into control (saline), model (10 mg/kg loperamide + saline), phenolphthalein (10 mg/kg loperamide + 10 mg/kg phenolphthalein) and different dosage of BCE (10 mg/kg loperamide + 40, 80 and 160 mg/kg BCE, respectively) groups, and received intragastric administrations for eight days. Faecal water content, number of faeces, first black-stool defecation time and gastrointestinal transit rates were evaluated. Various biochemical and molecular biomarkers were assessed in blood and colon. UPLC-ESI-QTOF-MS/MS was used to tentatively identify the composition of the BCE. Results BCE treatment (160 mg/kg) could increase faecal water (15.75%), faeces number (11.65%), gastrointestinal transit rate (25.37%) and decrease first black-stool defecation time (24.04%). The BCE (80 mg/kg) increased the serum level of motilin (30.62%), gastrin (54.46%) and substance P (18.99%), and decreased somatostatin (19.47%). Additionally, the BCE (160 mg/kg) reduced the mucosal damage, restored colonic goblet cell function, down-regulated the protein expression of AQP 3 (33.60%) and increased c-kit protein expression (11.63%). Twelve known compounds, including protocatechuic acid, chlorogenic acid and rutin, previously reported in B. ceiba, were identified in the BCE. Discussion and conclusions This study suggested that BCE is a promising agent for the treatment of constipation.

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“…For Thymus species, multiple studies have been conducted using mostly ethanol, methanol, water, and their mixture as solvents, in which not much variety was observed in the flavones extraction of such species as T. alternans, T. caespititius, T. fragrantissimus, T. mastichina, T. pulegioides, T. serpyllum, and T. vulgaris, among others [68,71,[117][118][119][120][121]. However, using fractionation techniques, it is possible to obtain flavones that have not been identified in crude extracts such as 7-methoxyapigenin (genkwanin) [122] and nobiletin [123,124], while, by using dichloromethane, hydroxyluteolin and hydroxyapigenin derivatives can be extracted from T. mastichina [125].…”

Section: Extraction Methods Of Flavones From Lamiaceae Plants 41 Conventional Methodsmentioning

confidence: 99%

Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review

et al. 2021

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Lamiaceae plants are a widespread family of herbaceous plants with around 245 plant genera and nearly 22,576 species distributed in the world. Some of the most representative and widely studied Lamiaceae plants belong to the Ocimum, Origanum, Salvia, and Thymus genera. These plants are a rich source of bioactive molecules such as terpenes, flavonoids, and phenolic acids. In this sense, there is a subgroup of flavonoids classified as flavones. Flavones have antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic potential; thus, efficient extraction techniques from their original plant matrixes have been developed. Currently, conventional extraction methods involving organic solvents are no longer recommended due to their environmental consequences, and new environmentally friendly techniques have been developed. Moreover, once extracted, the bioactivity of flavones is highly linked to their bioavailability, which is often neglected. This review aims to comprehensively gather recent information (2011–2021) regarding extraction techniques and their important relationship with the bioavailability of flavones from Lamiaceae plants including Salvia, Ocimum, Thymus, and Origanum.

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The potential of Thymus vulgaris aqueous extract to protect against delayed gastric emptying and colonic constipation in rats

Abstract: Thyme is a rich source of bioactive phytochemicals and it is frequently used in folk-medicine to treat gastroenteritis irritations.

Cited by 6 publications

References 49 publications

Hepatoprotective activities of thyme (Thymus vulgaris L.) in rats suffering from obesity.

Hepatoprotective activities of thyme (Thymus vulgaris L.) in rats suffering from obesity.

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Extraction Processes Affect the Composition and Bioavailability of Flavones from Lamiaceae Plants: A Comprehensive Review

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