Vimentin-Positive Squamous Cell Carcinoma Arising in a Burn Scar

Ikegawa, Shuichi; Saida, Toshiaki; Takizawa, Yukio; Tokuda, Yasutaka; Ito, Takashi; Fujioka, Fumio; Sakaki, Tetsuhiko; Uchida, Naoyuki; Arase, Seiji; Takeda, Katsuyuki

doi:10.1001/archderm.1989.01670240072017

Cited by 31 publications

(3 citation statements)

References 10 publications

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“…However, the observation of epithelial-tomesenchymal transition and its implication in metastatic progression has recently been reported in a breast-carcinoma cell line (Bae et al, 1993). Moreover, even though the expression of vimentin has rarely been found in normal epithelial cells, it has already been observed in squamous-cell carcinoma (Ikegawa et al, 1989). A correlation between the invasive potential of melanoma tumor cells and the coexpression of vimentin and keratins has also been described (Ramaekers et al, 1983).…”

Section: Discussionmentioning

confidence: 98%

Differentiation ability and oncogenic potential of HPV‐33‐and HPV‐33+ras‐transfected keratinocytes

Gilles

Piette

Peter

et al. 1994

Intl Journal of Cancer

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Five HPV-33-immortalized and 5 HPV-33 + ras-transfected cell lines were characterized in terms of growth in soft agar, tumorigenic potential in nude mice, p21 expression, morphology and expression of differentiation markers in organotypic cultures. No striking differences were observed between the HPV-33-immortalized cell lines and their corresponding ras-transfected counterparts as regards their tumorigenicity in nude mice (only one cell line was able to develop tumors in nude mice) or their behavior on lifted collagen gels. However, all the ras-transfected cell lines gave rise to colonies in soft agar while only 2 HPV-33-transfected lines (CK1 and CK4) displayed this property. The 10 cell lines could be divided into 2 groups with respect to their phenotype in monolayer and in organotypic cultures. Lines from group I (CK2, 3, 5 and their ras-transfected homologous lines) shared a typical epithelial phenotype in monolayer and the ability (a) to form an epithelium similar to a CIN-III lesion and (b) to strongly express keratins K1-K10 and involucrin in organotypic cultures. On the other hand, for the lines from group II (CK1, CK4, CK1EJ7 and CK4EJ5), there was a correlation between an elongated phenotype in monolayer and the property (a) to form a structure similar to a microinvasive carcinoma and (b) to express vimentin and keratins K8-K18. These cell lines, exhibiting various transformation-associated alterations, can be considered as an in vitro model representing various stages of HPV-33-associated cervical carcinogenesis.

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Section: Discussionmentioning

confidence: 98%

Differentiation ability and oncogenic potential of HPV‐33‐and HPV‐33+ras‐transfected keratinocytes

Gilles

Piette

Peter

et al. 1994

Intl Journal of Cancer

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“…However, it is now generally recognized that, in addition to the proportion of differentiated cells, the degree of atypicality of the tumor cells and the depth of the penetration of the lesion are important factors in grading (11). Furthermore, vimentin‐positive SCC composed of acantholytic round neoplastic cells was a highly malignant subset of cutaneous SCC (12, 13). Other factors of importance are the architectural patterns of invasion (14).…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Squamous Cell Carcinoma Showing Continuous Mesenchymal Dedifferentiation in a Single Tumor

Seike¹,

Ikeda

Nakajima

et al. 2005

The Journal of Dermatology

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We report the case of an 85-year-old man who presented with an enlarging tumor on the right temple. Histologically, spindle-shaped cells were proliferating continuously within well-differentiated squamous cell carcinoma that was immunohistochemically negative for vimentin and alpha-smooth muscle actin (ASMA) but positive for cytokeratin (AE1/3). These spindle-shaped cells expressed vimentin and ASMA but not cytokeratin (AE1/3). Intermediate cells with round nuclei and small amounts of cytoplasm displayed slight expression of vimentin, ASMA, and cytokeratin. This case illustrated spindle cell squamous cell carcinoma with mesenchymal metaplasia of malignant epithelial cells.

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“…The peculiar appearance is biologically caused by acantholysis, wherein neoplastic tumor cells demonstrate defective cohesion to one another and lack glandular differentiation. Acantholytic squamous cell carcinoma has been reported in several organs including the skin, oral mucosa, nasopharynx, larynx, breast, lung, vulva and uterine cervix 1 –14 …”

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confidence: 99%

Pseudovascular squamous cell carcinoma of the uterine cervix: A lesion that may simulate an angiosarcoma

Horie

Kato

1999

Pathology International

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A case of pseudovascular squamous cell carcinoma in the uterine cervix of a 64-year-old woman was examined. Histologically, the lesion consisted of atypical, large, non-keratinizing squamous cells that exhibited not only acantholytic changes but also pseudovascular changes. Immunohistochemically, these tumor cells were positive for cytokeratin, epithelial membrane antigen and carcinoembryonic antigen, but none of them were positive for Factor VIII-related antigen or CD34. To our knowledge, pseudovascular carcinoma of the uterine cervix has not been described in the literature. Pathologists should be aware of this unusual form of cervical squamous cell carcinoma, particularly in the differential diagnosis of angiosarcoma.

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Vimentin-Positive Squamous Cell Carcinoma Arising in a Burn Scar

Cited by 31 publications

References 10 publications

Differentiation ability and oncogenic potential of HPV‐33‐and HPV‐33+ras‐transfected keratinocytes

Differentiation ability and oncogenic potential of HPV‐33‐and HPV‐33+ras‐transfected keratinocytes

Spindle Cell Squamous Cell Carcinoma Showing Continuous Mesenchymal Dedifferentiation in a Single Tumor

Pseudovascular squamous cell carcinoma of the uterine cervix: A lesion that may simulate an angiosarcoma

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