Pseudovascular squamous cell carcinoma of the uterine cervix: A lesion that may simulate an angiosarcoma

Horie, Yasushi; Kato, Masako

doi:10.1046/j.1440-1827.1999.00841.x

Cited by 22 publications

(14 citation statements)

References 23 publications

(24 reference statements)

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“…In humans, PASCC has been reported in the lung, 13 breast, 1,2 female reproductive tract, 6 skin, 2,10 and oral cavity. 9,15 In contrast to the present case, the human reports of oral involvement do not mention tumor invasion into the underlying bone.…”

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confidence: 99%

“…5 The human entity is characterized by anastomosing cords of epithelioid cells, with multiple vascular clefts formed within the neoplastic nodules. 1,2,6,10,13,15 The vascular clefts are believed to be caused by acantholysis of the neoplastic cells that occurs at the center of the neoplastic cords, with subsequent infiltration of these clefts by erythrocytes. Decreased expression of intercellular adhesion molecules, such as E-cadherin and syndecan-1, results in decreased adhesion of epithelial cells, which eventually leads to acantholysis.…”

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confidence: 99%

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Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

et al. 2010

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Abstract. An 8-year-old, spayed, female Labrador Retriever mixed-breed dog was presented to the Cornell University Hospital for Animals with an invasive oral mass involving the upper left fourth premolar and first molar teeth. Initial biopsy results suggested a poorly differentiated squamous cell carcinoma, whereas further histologic examination of the surgically removed mass revealed a hemangiosarcoma-like mass composed of numerous vascular clefts and variable numbers of keratinizing epithelial cells. Histologic and immunohistochemical characteristics were compatible with pseudoangiomatous squamous cell carcinoma, a wellrecognized human variant of acanthomatous squamous cell carcinoma. Because of histomorphologic similarities with canine gingival hemangiosarcoma, diagnosticians should be aware of the present tumor variant as a differential diagnosis for vascular-like growths in the oral cavity of dogs.

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Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

et al. 2010

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“…The pseudoangiosarcomatous carcinoma previously reported by Pitt et al 6 also had focal squamous keratinization and sarcomatoid spindle cell component. Most of the previously reported nonvesical pseudoangiosarcomatous carcinomas were squamous cell carcinoma in cutaneous and squamous mucosal sites, 2,4,5,8,11,[13][14][15][16] as well as in some visceral organs where squamous carcinoma is not typical, such as in the breast and colon. 3,7,9,10 In the current series, a relatively higher proportion of the bladder carcinomas (4/7) showed squamous differentiation, and the pseudoangiosarcomatous pattern was also exhibited by the squamous areas in 3 of the 7 tumors.…”

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confidence: 99%

“…[1][2][3][4][5][6] These carcinomas were also reported under different eponyms such as acantholytic, pseudovascular, angiosarcoma-like, pseudoglandular, adenoid squamous, and pseudovascular adenoid squamous carcinomas. 1,2,5,[7][8][9][10][11][12][13][14] Most of the pseudoangiosarcomatous carcinomas previously described were squamous cell carcinomas from various organ sites such as the skin, 2-4,13 conjunctiva, 15 aerodigestive mucosa, 11,16 lungs, 3,12 breast, 3,9,10 cecum, 7 vulva, 5,6,8 uterine cervix, 14 and penis. 17 The pseudoangiosarcomatous pattern has also been described in poorly differentiated and sarcomatoid ductal carcinoma of the breast.…”

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Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Paner

Cox

Richards

et al. 2014

American Journal of Surgical Pathology

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The pseudoangiosarcomatous pattern has been described mostly in cutaneous and some visceral squamous cell carcinomas and is unique for its striking morphologic resemblance to angiosarcoma. Herein, we describe the clinicopathologic features of 7 pseudoangiosarcomatous urothelial carcinomas that occurred in the urinary bladder. The patients included 6 men and 1 woman ranging in age from 47 to 87 years (median 70 y). The pseudoangiosarcomatous morphology was observed in 7 urothelial carcinomas including 3 with squamous differentiation and comprised 35% to 85% of the invasive tumor. Histologically, the pseudoangiosarcomatous carcinomas were characterized by tumor cell discohesion and lysis that created pseudolumina formations surrounded by attached residual tumor cells. Detached degenerating tumor cells variably admixed with inflammatory cells were common in the false lumina. Partly intact urothelial carcinoma nests contained irregular or cleft-like spaces and disintegrating tumor cells with stretched intercellular bridges. The tumor was commonly associated with a dense collagenous matrix, often surrounding the lytic nests. Similar tumor cell discohesion and breakdown were observed in 3 tumors with foci of squamous cell differentiation, distinguished by the presence of dyskeratosis and keratin formation. All 7 tumors contained other nonpseudoangiosarcomatous carcinoma components such as conventional urothelial carcinoma (5), squamous differentiation (4), sarcomatoid spindle cell carcinoma (2), small cell carcinoma (1), micropapillary carcinoma (1), and glandular differentiation (1). The pseudoangiosarcomatous urothelial carcinomas were all (7/7) diffusely CK7 positive, most (6/7) were GATA3 positive, and none (0/7) expressed vascular-associated markers. There was no evidence to suggest that apoptosis (by TUNEL assay and cleaved caspase-3 immunostaining) or loss of the adhesion molecules CD138 and e-cadherin were possible causes for the tumor cell discohesion and breakdown. All 7 tumors were high stage at cystectomy and included 1 pT3a, 2 pT3b, and 4 pT4a tumors, and 3 had pelvic lymph node involvement. Follow-up data available in 6 cases revealed a poor outcome with an overall median survival of 8.5 months. In conclusion, we present an unusual morphology of bladder carcinoma that has a striking resemblance to a malignant vasoformative tumor. Our series showed that bladder pseudoangiosarcomatous carcinoma morphology is associated with a higher tumor stage at cystectomy, commonly admixed with other aggressive carcinoma variant morphologies, and portend a poorer outcome. Knowledge of this pattern is also important to avoid misdiagnosis, particularly in limited tissue samples.

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“…1 It has been reported in different organs such as the lung, 1-3 breast, 2,4 and the uterine cervix. 5 Cutaneous pseudoangiosarcomatous squamous cell carcinomas are very rare, and the appearance near chronic ulcers is exceptional.…”

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Pseudoangiosarcomatous Squamous Cell Carcinoma of Skin Arising Adjacent to Decubitus Ulcers

Conde‐Taboada

Flórez

Torre

et al. 2005

The American Journal of Dermatopathology

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Pseudoangiosarcomatous, or pseudovascular, squamous cell carcinoma of skin is an unusual form of acantholytic (adenoid, pseudoglandular) squamous cell carcinoma that mimics the histolopathologic appearance of angiosarcoma. We report a case of pseudoangiosarcomatous squamous cell carcinoma arising adjacent to decubitus ulcers. The histopathologic examination of a wedge biopsy specimen revealed infiltrative cords of neoplastic cells that formed interanastomosing channels imitating angiosarcoma. Immunohistochemical staining was negative for the endothelial markers (CD31, CD34, and factor VIII-related antigen) and positive using cytokeratin antibodies (AE1/AE3 and 34 betaE12). Because of metastatic disease, palliative measures were undertaken and the patient died four months later. To our knowledge, our patient is the first with pseudoangiosarcomatous squamous cell carcinoma of skin developing within decubitus ulcer.

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Pseudovascular squamous cell carcinoma of the uterine cervix: A lesion that may simulate an angiosarcoma

Cited by 22 publications

References 23 publications

Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

Pseudoangiomatous Squamous Cell Carcinoma in the Oral Cavity of a Dog

Pseudoangiosarcomatous Urothelial Carcinoma of the Urinary Bladder

Pseudoangiosarcomatous Squamous Cell Carcinoma of Skin Arising Adjacent to Decubitus Ulcers

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