Vimentin as antigenic target in autoimmunity: A comprehensive review

Musaelyan, A. A.; Лапин, С. В.; Назаров, В. Д.; Tkachenko, Olga; Gilburd, Boris; Мазинг, А. В.; Mikhailova, Lilia V; Shoenfeld, Yehuda

doi:10.1016/j.autrev.2018.04.004

Cited by 84 publications

(56 citation statements)

References 103 publications

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“…After becoming antigenic with a still unexplained mechanism, Vimentin is exposed and could be bound by anti-vimentin antibodies (AVA). 47,48 Vimentin could also electrically interact with cardiolipin on the surface of apoptotic cells generating the vimentin/cardiolipin complex. Antibodies against this complex (vimentin/cardiolipin antibodies, AVA/CL) show a prothrombotic effect.…”

Section: Anti-vimentin/cardiolipin Complexmentioning

confidence: 99%

Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

et al. 2020

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Section: Anti-vimentin/cardiolipin Complexmentioning

confidence: 99%

Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

et al. 2020

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“…Recent studies suggest that the mesenchymal protein vimentin, may be an autoantigen for sarcoidosis. The presence of autoantibodies to this protein is described in the pathogenesis of rheumatoid arthritis, systemic lupus erythematosus, and many other systemic autoimmune diseases (40,41).…”

Section: The Role Of Vimentin As An Autoantigen In Sarcoidosismentioning

confidence: 99%

Sarcoidosis as an Autoimmune Disease

et al. 2020

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Despite the large number of performed studies, the etiology and pathogenesis of sarcoidosis still remain unknown. Most researchers allude to the possible autoimmune or immune-mediated genesis of the disease. This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoidosis and "classic" autoimmune diseases, the role of triggering factors in the development of sarcoidosis, the presence of immunogenic susceptibility in the development of the disease, and the analysis of cellular and humoral immune responses in sarcoidosis. Studying the etiology and pathogenesis of sarcoidosis will improve diagnostic procedures as well as the prognosis and patients' quality of life.

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“…18,19 There is evidence that vimentin, an antigenic target in autoimmune disease, may function as an autoantigen in sarcoidosis as suggested by the observation of increased vimentin-specific antibodies that correlate with other markers of T-cell activation in sarcoidosis. 20,21 Nonspecific serum autoantibodies are also a common finding in many sarcoidosis patients [22][23][24][25][26] (►Table 3). Positive antinuclear antibodies (ANAs) and elevated rheumatoid factor (RF) levels are more commonly observed in sarcoidosis patients (30% and 16-38%, respectively) compared with healthy controls, while more specific autoantibodies such as anti-dsDNA and anti-CCP are less prevalent but still more common than controls in most sarcoidosis cohorts.…”

Section: Connective Tissue Diseasementioning

confidence: 99%

Overlap Syndromes in Sarcoidosis: Clinical Features and Outcomes

James

2020

Semin Respir Crit Care Med

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Sarcoidosis is a multisystem inflammatory disease characterized by noncaseating granulomatous inflammation. While pulmonary sarcoidosis is most common, extrapulmonary involvement occurs in 50 to 74% of patients and can be the presenting abnormality in some patients. The diagnosis of sarcoidosis is based on a compatible clinical presentation in combination with granulomas on histology and exclusion of other causes. However, the absence of a diagnostic biomarker for sarcoidosis, in addition to the overlap of granulomatous inflammation and nonspecific clinical findings with other diseases, often results in a delayed diagnosis. Sarcoidosis overlap syndromes are typically described when sarcoidosis is diagnosed in the presence of another disease (concurrently or sequentially) with shared clinical and histologic features, or when sarcoidosis presents with clinical features typically observed in, but not diagnostic of, other diseases. Awareness of overlap syndromes is important for clinicians to avoid diagnostic errors and evaluate for concomitant diagnoses that may impact the management and outcome of sarcoidosis. This article is intended to provide an overview of these presentations and the most commonly associated diseases, with attention to their prevalence, clinical features, and reciprocal impacts on disease outcomes.

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Vimentin as antigenic target in autoimmunity: A comprehensive review

Cited by 84 publications

References 103 publications

Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

Seronegative antiphospholipid syndrome: refining the value of “non-criteria” antibodies for diagnosis and clinical management

Sarcoidosis as an Autoimmune Disease

Overlap Syndromes in Sarcoidosis: Clinical Features and Outcomes

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