Sarcoidosis as an Autoimmune Disease

Старшинова, Анна; Малкова, Анна; Basantsova, Natalia; Zinchenko, Yulia; Kudryavtsev, I. V.; Ershov, Gennadiy A.; Сопрун, Лидия; Mayevskaya, Vera; Чурилов, Леонид Павлович; Yаblonskiy, Petr

doi:10.3389/fimmu.2019.02933

Cited by 71 publications

(75 citation statements)

References 80 publications

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“…Vimentin-derived peptides are the most plausible candidate for the activation of both T-cells and B-cells in the lung [58]. Autoimmunity presents a as a novel spectrum for sarcoidosis immunopathogenesis and may help elucidate sarcoid etiology [59][60][61].…”

Section: Autoimmunitymentioning

confidence: 99%

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Jain

Yadav

Puranik

et al. 2020

JCM

119

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Sarcoidosis is a multisystem granulomatous disease with nonspecific clinical manifestations that commonly affects the pulmonary system and other organs including the eyes, skin, liver, spleen, and lymph nodes. Sarcoidosis usually presents with persistent dry cough, eye and skin manifestations, weight loss, fatigue, night sweats, and erythema nodosum. Sarcoidosis is not influenced by sex or age, although it is more common in adults (< 50 years) of African-American or Scandinavians decent. Diagnosis can be difficult because of nonspecific symptoms and can only be verified following histopathological examination. Various factors, including infection, genetic predisposition, and environmental factors, are involved in the pathology of sarcoidosis. Exposures to insecticides, herbicides, bioaerosols, and agricultural employment are also associated with an increased risk for sarcoidosis. Due to its unknown etiology, early diagnosis and detection are difficult; however, the advent of advanced technologies, such as endobronchial ultrasound-guided biopsy, high-resolution computed tomography, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography has improved our ability to reliably diagnose this condition and accurately forecast its prognosis. This review discusses the causes and clinical features of sarcoidosis, and the improvements made in its prognosis, therapeutic management, and the recent discovery of potential biomarkers associated with the diagnostic assay used for sarcoidosis confirmation.

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Section: Autoimmunitymentioning

confidence: 99%

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Jain

Yadav

Puranik

et al. 2020

JCM

119

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“…One autoantigen was shared by all 3 screening sera of patients with sarcoidosis: Negative elongation factor E (NELF-E; RNA-binding protein RD) ( Figure 2). We compared our results with former protein array screenings, which were performed in former studies [13][14][15][16][17][18]. NELF-E antibodies were not detected in any of these protein screening arrays from patients with GPA (n = .…”

Section: Protein Array Resultsmentioning

confidence: 99%

“…Despite numerous attempts, only circumstantial evidence exists to regard sarcoidosis as an autoimmune disease, including its response to immunosuppressive therapy, association with certain Human Leucocyte Antigen (HLA) genotypes and detection of some autoantibodies that are also associated with other autoimmune diseases such as antimitochondrial, antinuclear, anti-double stranded deoxyribonucleic acid (DNA) and citrullinated cyclic peptide antibodies [13].…”

Section: Introductionmentioning

confidence: 99%

Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis

Baerlecken¹,

Pursche

Witte

et al. 2020

JCM

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Sarcoidosis is characterized by multiorgan involvement and granulomatous inflammation. Its origin is unknown and the potential role of autoimmunity has not been sufficiently determined. We investigated the presence of autoantibodies in sarcoidosis using protein array technology. The derivation cohort consisted of patients with sarcoidosis (n = 25) and controls including autoimmune disease and blood donors (n = 246). In addition, we tested a validation cohort including pulmonary sarcoidosis patients (n = 58) and healthy controls (n = 13). Initially, sera of three patients with sarcoidosis were screened using a protein array with 28.000 proteins against controls. Thereby we identified the Negative Elongation Factor E (NELF-E) as an autoantigen. With confirmatory Enzyme-linked Immunosorbent Assay (ELISA)testing, 29/82 patients (35%) with sarcoidosis had antibodies against NELF-E of the Immunoglobulin (Ig) G type, whereas 18/253 (7%) sera of the controls were positive for NELF-E. Clinically, there was an association of the frequency of NELF-E antibody detection with lung parenchymal involvement and corresponding x-ray types. NELF-E autoantibodies are associated with sarcoidosis and should be further investigated.

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“…Interestingly, B cells might also play a role in the autoimmune phenomena associated with the onset and progression of sarcoidosis. In fact, several types of autoantibodies have been found, both circulating and associated with the lung tissue, in patients with sarcoidosis, such as anti-mitochondrial, anti-nuclear antibodies, and autoantibodies to double-stranded DNA [70]. Case-report evidence of responses to rituximab exists in extrapulmonary sarcoidosis but not for pulmonary disease as yet [71].…”

Section: B Cellsmentioning

confidence: 99%

Clinical Presentations, Pathogenesis, and Therapy of Sarcoidosis: State of the Art

Polverino

Balestro

Spagnolo

2020

JCM

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Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no single reliable diagnostic test. Prognosis is variable and depends on epidemiologic factors, mode of onset, initial clinical course, and specific organ involvement. From a pathobiological standpoint, sarcoidosis represents an immune paradox, where an excessive spread of both the innate and the adaptive immune arms of the immune system is accompanied by a state of partial immune anergy. For all these reasons, the optimal treatment for sarcoidosis remains unclear, with corticosteroid therapy being the current gold standard for those patients with significantly symptomatic or progressive pulmonary disease or serious extrapulmonary disease. This review is a state of the art of clinical presentations and immunological features of sarcoidosis, and the current therapeutic approaches used to treat the disease.

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Sarcoidosis as an Autoimmune Disease

Cited by 71 publications

References 80 publications

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Presence of Antibodies Binding to Negative Elongation Factor E in Sarcoidosis

Clinical Presentations, Pathogenesis, and Therapy of Sarcoidosis: State of the Art

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