Vimentin: an evaluation of its role as a tumour marker

Leader, M.; Collins, M.; Patel, J.; Henry, Kristin

doi:10.1111/j.1365-2559.1987.tb02609.x

Cited by 148 publications

(51 citation statements)

References 36 publications

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“…Vimentin is a structural protein from cells of mesenchymal origin (Leader et al, 1987). Its expression is higher in migratory epithelial cells and may contribute to the migratory and invasive phenotype of metastatic cells (Bindels et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer

et al. 2008

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Vimentin, nuclear factor-kB (NF-kB) p105, fascin, E-cadherin, TGF-b, Par6 and atypical PKC are molecular markers that play an important role in cell differentiation. Herein, we investigate their prognostic impact in primary non-small-cell carcinoma (NSCLC). Tumour tissue samples from 335 resected patients with stage I -IIIA were used. Tissue microarrays were constructed from duplicate cores of both neoplastic cells and stromal cells and were immunohistochemically evaluated. In univariate analyses, high tumour epithelial cell expressions of NF-kB p105 (P ¼ 0.02) and E-cadherin (P ¼ 0.03) were positive prognostic indicators for disease-specific survival (DSS), whereas high tumour epithelial cell expression of vimentin (P ¼ 0.001) was a negative prognostic indicator. High expression of NF-kB p105 (P ¼ 0.001) and Par6 (P ¼ 0.0001) in the stromal compartment correlated with a good prognosis. In multivariate analyses, the tumour epithelial cell expression of NF-kB p105 (P ¼ 0.0001) and vimentin (P ¼ 0.005) and the stromal cell expression of NF-kB p105 (P ¼ 0.007) and Par6 (P ¼ 0.0001) were independent prognostic factors for DSS. High expression of NF-kB p105 and low expression of vimentin in tumour epithelial cells are independent predictors of better survival in primary NSCLC. In stromal cells, high expressions of NF-kB p105 and Par6 are both favourable independent prognostic indicators.

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Section: Discussionmentioning

confidence: 99%

The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer

et al. 2008

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“…Intense immune-reaction of tumor cells to markers (vimentin, CD34, CD99, actin) that stain normal tissues and neoplasms of mesenchymal origin (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28); in contrast, they do not stain with cytokeratins, which represent a marker for epithelial differentiation. 2.…”

Section: Etio-pathogenetic Hypothesesmentioning

confidence: 99%

Solitary Fibrous Tumor of the Thyroid Gland

Papi

Corrado

Uberti

et al. 2007

Thyroid

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Solitary fibrous tumor (SFT) is a rare spindle-cell neoplasm more commonly involving the pleura, but recognized also in other tissues. Nineteen patients with SFT arising from the thyroid gland have been reported in the literature. The present report reviews these cases and discusses epidemiology, etio-pathogenesis, clinical-pathologic characteristics, differential diagnosis, therapy, and prognosis of thyroid SFT.

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“…It provides flexibility to the cell, and integrity (Goldman et al 1996). Through the various experimental setups it has been found that it is used as a marker for sarcoma tumour to identify the mesenchyme (Leader et al 1987). Further investigation reveals that it regulates the interaction of various cytoskeletal proteins with that of cell adhesion molecules and thereby plays a pivotal role in migration, invasion, signalling and adhesion.…”

Section: Vimentinmentioning

confidence: 99%