“…To our knowledge, a review summarizing the literature on the synthesis and chemistry of thieno[2,3‐ b ]quinolines was little known in the literature [35], we report herein a systematic and comprehensive survey of the methods of preparation and the chemical reactivity of thieno[2,3‐ b ]quinolines, which might show interesting biological activities.…”
As a continuation of our previous review entitled “Vilsmeier‐Haack cyclisation as a facile synthetic route to thieno[2,3‐b]quinolines (Part I).” This review describes the methods of preparation and the chemical reactivity of thieno[2,3‐b]quinolines, which might show interesting biological activities.
“…To our knowledge, a review summarizing the literature on the synthesis and chemistry of thieno[2,3‐ b ]quinolines was little known in the literature [35], we report herein a systematic and comprehensive survey of the methods of preparation and the chemical reactivity of thieno[2,3‐ b ]quinolines, which might show interesting biological activities.…”
As a continuation of our previous review entitled “Vilsmeier‐Haack cyclisation as a facile synthetic route to thieno[2,3‐b]quinolines (Part I).” This review describes the methods of preparation and the chemical reactivity of thieno[2,3‐b]quinolines, which might show interesting biological activities.
:
This review described the preparation of 2- chloroquinoline-3-carbaldehyde derivatives 18 through Vilsmeier-Haack formylation of N-arylacetamides and use of them as a key intermediate for preparation of 2-(piperazin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2-(piperazin-1-yl) quinolines derivatives was explained through the following chemical reactions: acylation, sulfonylation, Claisen-Schmidt condensation, 1, 3-dipolar cycloaddition, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction and Kabachnik-Field’s reaction.
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