Synthesis and reactivity of thieno[2,3‐<i>b</i>]quinoline derivatives (Part <scp>II</scp>)

Salem, Mohamed Salem Ould Ahmedou; Abu‐Hashem, Ameen A.; Abdelgawad, Ahmed A. M.; Gouda, Moustafa A.

doi:10.1002/jhet.4269

Cited by 16 publications

(1 citation statement)

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“…There are also some researchers to use greener method for the synthesis of several quinoline derivatives. Many review articles related to the synthesis of quinolines were published, such as synthesis of derivatives of thieno [2,3-b]quinoline (Part-II) was reviewed by Mohammed A. Salem et al in 2021, [1] synthesis of derivatives of thieno [3,2-b]quinoline derivatives (Part-III) was reviewed in 2021 by Moustafa A. Gouda and team, [2] review article related to preparations of tetrahydrothieno [3,2b]quinolines (Part-IV) was published in 2022 by Ameen A. Abu-Hashem and team, [3] reactions associated with thieno [3,2c]quinolines (Part-V and Part-VI) were reported by Ameen A. Abu-Hashem in 2021 [4] and Moustafa A. Gouda et al in 2022 [5] respectively.…”

Section: Introductionmentioning

confidence: 99%

Quinoline N‐Oxide: A Versatile Precursor in Organic Transformations

2022

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Quinoline derivatives are very widely known biologically active heterocyclic compounds, as for example quinine, mefloquine, etc. In recent years, the interests of researchers are growing to look for a methodology using quinoline N-oxides as a precursor to make several bio-active quinoline compounds as quinoline N-oxides are more reactive with good regioselectivity than unoxidized quinolines. In this review, numerous procedures are discussed using quinoline N-oxides as a versatile precursor in organic transformations, such as alkenylation, alkylation, arylation, amination, amidation, halogenation and so on under metal or metal-free conditions at C-2, C-3 or C-8 positions. The main focus of this context is to explore various procedures of synthesis of quinoline derivatives with good regioselectivity, to understand the extent of usefulness of those procedures through the study of scope of substrates and the reaction mechanisms of the processes.

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