“…If we include the observations (Womack et al, 1988), which suggest that villous motility (frequency) is increased by a myogenic response to an increased intravillous fluid pressure, and if we think in terms of stretchsensitive, contractile pacemaker cells, it seems that there is a very good case for a mechanism basically similar to the one that may be operative in the muscularis-only, we will have to reverse Gü ldner's order of events: rather than having the villous smooth muscle cells initiating the events, the network of intravillous myofibroblasts would be spontaneously, and rhythmically contracting 19 (like ICC) and would be the primary sensors of stretch due to dilation of interstices, responding by increased contraction frequency to increased rates of fluid transport.…”