One hundred years of interstitial cells of Cajal

Thuneberg, Lars

doi:10.1002/(sici)1097-0029(19991115)47:4<223::aid-jemt2>3.0.co;2-c

Cited by 99 publications

(72 citation statements)

References 70 publications

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“…It is well known that interstitial cells of Cajal (ICC) are present in various portions of intestinal wall; within longitudinal and circular muscle layer, myenteric plexus, deep muscular plexus and submucosal plexus (see for review ;Thuneberg, 1999;Hanani and Freund, 2000). In the mouse ileum, ICC are present in the myenteric (Auerbach's) plexus (ICC-MY) and deep muscular plexus (ICC-DMP).…”

Section: Introductionsupporting

confidence: 52%

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

Okishio

Takeuchi

Fujita

et al. 2005

J. Smooth Muscle Res.

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Recently an essential role of interstitial cells of Cajal (ICC) within myenteric plexus (ICC-MY) was suggested in ascending contraction and descending relaxation in the mouse ileum. The role of ICC in these neural reflexes was examined in the distal colonic segments prepared from the wild type and c-kit mutant, W/W V mice, in the present study. Localized distension of the segments from the wild type mice by using a small balloon resulted in ascending contraction and descending relaxation. In the segments from the mutant mice, localized distension also induced these neural reflexes similar to those observed in the wild type mice. Immunohistochemical examination demonstrated that ICC-MY and ICC present in muscle layers (ICC-IM) were severely disrupted in the mutant mouse, but only ICC, present within submucosal plexus (ICC-SMP), remained unchanged. In the small strips with ICC-SMP absent prepared from the mutant mouse, electrical field stimulation induced contraction or relaxation in the absence or presence of atropine, respectively. It was suggested that ICC have no important role in the ascending and descending neural reflexes in the mouse distal colon, this is in direct contrast to the role of ICC-MY in the ileum.

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Section: Introductionsupporting

confidence: 52%

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

Okishio

Takeuchi

Fujita

et al. 2005

J. Smooth Muscle Res.

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“…Since the spindle-shaped interstitial cells of Cajal (ICC) were found by Cajal about one hundred years ago, 3 numerous publications have contributed to find their origin and function. However, recent research from 1982 4 found that ICC played a role of pacemaker in gut motility and the proto-oncogene c-kit was critical in the development of ICC.…”

Section: Econium Ileus Is Expressed Mainly As a Clin-mentioning

confidence: 99%

Delayed maturation of interstitial cells of Cajal in meconium obstruction

Yoo

Jung

Eom

et al. 2002

Journal of Pediatric Surgery

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“…In any case, Cajal's studies formed the basis of intense discussions in subsequent studies at the light microscopy level in the Netherlands and elsewhere and the 'interstitial neurons" were thought to be pacemaker cells or connective tissue cells and named interstitial cells of Cajal (ICC) (see [5,6] for review). In the 1970s and 1980s, cells that were considered to correspond to the "interstitial neurons" discovered by Cajal were described using electron microscopy (EM) in the musculature of the intestinal tract of several mammals, fully defined at that level by FaussonePellegrini, Thuneberg and Rumessen [5,[7][8][9].…”

mentioning

confidence: 99%

About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract

Huizinga¹,

Faussone–Pellegrini²

2005

J Cellular Mol Med

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Santiago Ramon y Cajal observed a special cell type that appeared to function as endstructures of the intrinsic nervous system in several organs. These cells were structurally and functionally further characterized in the gut musculature and named interstitial cells of Cajal (ICC). In recent years, interstitial cells have been identified in the vasculature, urinary tract, glands and other organs. Their morphologies and functions are just beginning to be clarified. It is likely that amongst them, subtypes will be discovered that warrant the classification of interstitial cells of Cajal. This “point of view” continues the discussion on the criteria that should be used to identify ICC outside the musculature of the gut.

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One hundred years of interstitial cells of Cajal

Cited by 99 publications

References 70 publications

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

Ascending contraction and descending relaxation in the distal colon of mice lacking interstitial cells of Cajal

Delayed maturation of interstitial cells of Cajal in meconium obstruction

About the presence of interstitial cells of Cajal outside the musculature of the gastrointestinal tract

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