Villous adenoma of urethra associated with tubulovillous adenoma and adenocarcinoma of rectum

Dr, Morgan; Mf, Dixon; Harnden, Patricia

doi:10.1046/j.1365-2559.1998.0241e.x

Cited by 12 publications

(4 citation statements)

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“…Villous adenomas have been described at all three sites, possibly because of the presence of remnants as a result of this common embryologica l pathway' (Morgan and Dixon, 1998). The latter then divides into three parts: the presumptive bladder, the pelvic urethra and the presumptive definitive urogenital sinus, which becomes the vestibule of the vagina.…”

Section: Discussionmentioning

confidence: 99%

Gynaecology Case Reports

2001

Journal of Obstetrics and Gynaecology

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ISSN 0 1 4 4 -3 6 1 5 print/ISSN 1 3 6 4 -6 8 9 3 online/0 1 /0 2 0 0 2 0 0 -1 2 ã T aylor & Francis Limited, 2 0 0 1 DOI: 1 0 .1 0 8 0 /0 1 4 4 6 1 0 0 2 0 0 2 6 2 0 9 GYNAECOLOGY CASE REPORTS Case report Ms NS was 30 years old and had been seen by her general practitioner, with a 21-month history of primary infertility. She also had abdominal discomfort and fullness over the previous 6 months. She had a normal menstrual cycle of 28 days, bleeding for 3-5 days. There was no menorrhagia or dysmenorrhoe a. She was found to have a palpable suprapubic mass on examination and was referred to a general surgeon. A full blood count and barium follow-through were normal. An ultrasound scan showed the presence of a mass suspected to be a dermoid cyst, probably arising from the left ovary. She was then referred to the consultant gynaecologist.Initial examination by the gynaecologist showed a normal general and abdominal examination. On pelvic examination the uterus was anteverted and normal size with a 5-cm mass, palpable, superior to the uterus. The adnexae were normal.Routine blood investigations, including a full blood count, urea and electrolytes, liver function test and thyroid function were normal. The CEA was raised at 141·5 ng/ml (normal range 0-3). The CA-125 and CA19-9 were normal, as were her alpha feta protein and Beta HCG. A pelvic ultrasound scan showed a complex, septate, cystic lesion containing areas of hyperechogenic ity and fat-fluid levels, measuring 7×4·4×5·8 cm, lying in the midline. This could be seen indenting the superior-posterior wall of the bladder. The left ovary was also identified, though a clear plane of demarcation from the mass could not be seen. The uterus and right ovary were normal and could be seen separate to the mass. An initial impression of a left dermoid cyst was made.Magnetic resonance imaging showed a complex pelvic mass, largely fluid-filled, but with irregular septa. There was no signal suppression on the STIR sequence, suggesting the absence of fat. Therefore the appearance was not typical of a dermoid. There was no adenopathy or ascites.Ms NS underwent a laparotomy. A 7×7 cm bladder tumour adherent to the anterior abdominal wall peritoneum invading the dome of the bladder was noted. Both ovaries were normal except for a filmy strand on her right ovary, which looked like a fine adhesion. A partial cystectomy was performed to remove the tumour mass. The omentum, liver, bowel and diaphragm were free of tumour and there was no ascites. The bladder was repaired. Peritoneal washings were sent for cytology. This showed clusters of malignant glandular epithelial cells. The histology of the tumour mass showed a moderately differentiated mucinous adenocarcinoma arising within a urachal remnant. The bladder mucosal circumferential resection margins were free from malignancy. The histology of the filmy strand on the right ovary showed metastatic mucinous adenocarcinoma .A week after surgery she was reviewed by a consultant urologist. A cystogram showed the bladder to be of good volume. ...

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Section: Discussionmentioning

confidence: 99%

Gynaecology Case Reports

2001

Journal of Obstetrics and Gynaecology

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“…Villous adenoma of the urinary tract is a rare tumor, histologically close to colonic villous adenoma, which is encountered in the bladder, urachus, ureter and prostatic urethra 1–3. This tumor exceptionally affects the female urethra and only isolated case reports have been described with a coexistent adenocarcinoma (Table I) 1, 4–7. To the best of our knowledge, this is the first case to be described of villous adenoma of the vulvar urethra associated with concomitant adenosquamous carcinoma.…”

Section: Introductionmentioning

confidence: 87%

Adenosquamous carcinoma arising in villous adenoma from female vulvar urethra

Noël¹,

Fayt²,

Aguilar³

2006

Acta Obstet Gynecol Scand

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“…Male predominance has been reported (1,2,5). VAs of the female urethra are very rare with only seven cases in the English literature to our knowledge (Table I) (1,(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 91%

Villous adenoma arising in the urethra of a female with bladder augmentation history: a case report and review of the literature

Demir

Cin²,

Çitgez³

et al. 2020

TJPATH

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Villous adenomas (VAs) in the female urethra are rare with only seven cases in the English literature to our knowledge. In patients with bladder augmentation cystoplasty, the neoplasia development risk increases and most of these develop in the neobladder or anastomosis line. Only two cases of VA developing from the native bladder mucosa have been reported. Physical examination of a 76-year-old female who had a history of augmentation cystoplasty revealed a caruncula-like structure protruding from the urethral meatus. The urinary USG showed that the lesion had no relation with the bladder. The lesion was excised. Microscopically, it consisted of villous structures covered with pseudostratified intestinal type epithelium. Low-grade dysplasia was present in the epithelium but high-grade dysplasia or in-situ/invasive carcinoma was not observed. Immunohistochemical study showed positivity for CK7, CK20, EMA, CEA and CDX2. The case was reported as VA of the urethra. We presented the first VA case arising in the urethra of a female patient with intestinal bladder augmentation. Excision is curative for pure VAs. Transformation to carcinoma or recurrence has not been reported. However, in one third of the cases, a malignant tumor may accompany the lesion. Therefore, all excision material should be examined carefully. Routine endoscopic follow-up should be performed in cases with bladder augmentation.

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Villous adenoma of urethra associated with tubulovillous adenoma and adenocarcinoma of rectum

Cited by 12 publications

References 4 publications

Gynaecology Case Reports

Gynaecology Case Reports

Adenosquamous carcinoma arising in villous adenoma from female vulvar urethra

Villous adenoma arising in the urethra of a female with bladder augmentation history: a case report and review of the literature

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