Viktor Hamburger at 100: eight decades of neuroembryological research, 1920–2000

Oppenheim, Ronald W.; Lauder, Jean M.

doi:10.1016/s0736-5748(00)00072-1

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…During development, embryos show spontaneous movements well before sensory pathways are functionally organized (Movie S1). This behavior, called embryonic motility, was originally described more than a century ago (Preyer, 1885) and has been best characterized in chicken embryos by Hamburger and colleagues (for reviews see Bekoff, 2001; Oppenheim and Lauder, 2001). Modern electrophysiological studies have revealed that the embryonic motility is produced by spontaneous activity in cranial and spinal motoneurons, which is driven by neural networks in the brainstem and spinal cord (Fortin et al, 1995; O'Donovan, 1999; Marder and Rehm, 2005).…”

Section: Introductionmentioning

confidence: 99%

Large-scale synchronized activity in the embryonic brainstem and spinal cord

Momose‐Sato

Sato

2013

Front. Cell. Neurosci.

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In the developing central nervous system, spontaneous activity appears well before the brain responds to external sensory inputs. One of the earliest activities is observed in the hindbrain and spinal cord, which is detected as rhythmic electrical discharges of cranial and spinal motoneurons or oscillations of Ca2+- and voltage-related optical signals. Shortly after the initial expression, the spontaneous activity appearing in the hindbrain and spinal cord exhibits a large-scale correlated wave that propagates over a wide region of the central nervous system, maximally extending to the lumbosacral cord and to the forebrain. In this review, we describe several aspects of this synchronized activity by focusing on the basic properties, development, origin, propagation pattern, pharmacological characteristics, and possible mechanisms underlying the generation of the activity. These profiles differ from those of the respiratory and locomotion pattern generators observed in the mature brainstem and spinal cord, suggesting that the wave is primordial activity that appears during a specific period of embryonic development and plays some important roles in the development of the central nervous system.

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Section: Introductionmentioning

confidence: 99%

Large-scale synchronized activity in the embryonic brainstem and spinal cord

Momose‐Sato

Sato

2013

Front. Cell. Neurosci.

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“…The earliest studies of spontaneous activity in the chick embryo involve descriptions of embryonic motility observed in ovo . Preyer ( 1885 ) described this behavior more than a century ago, and it has been well characterized by Hamburger and Balaban ( 1963 ) (for reviews see Bekoff, 2001 ; Oppenheim and Lauder, 2001 ). Embryonic motility from stage 21 (E3.5, E: days of incubation in chicks) appears as periodically recurring sequences of slight flexions of the neck, with subsequently two or more S-waves extending from the head to the tail (Hamburger and Balaban, 1963 ).…”

Section: Large-scale Synchronized Activitymentioning

confidence: 97%

Development of Spontaneous Activity in the Avian Hindbrain

Momose‐Sato

Sato

2016

Front. Neural Circuits

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Spontaneous activity in the developing central nervous system occurs before the brain responds to external sensory inputs, and appears in the hindbrain and spinal cord as rhythmic electrical discharges of cranial and spinal nerves. This spontaneous activity recruits a large population of neurons and propagates like a wave over a wide region of the central nervous system. Here, we review spontaneous activity in the chick hindbrain by focusing on this large-scale synchronized activity. Asynchronous activity that is expressed earlier than the above mentioned synchronized activity and activity originating in midline serotonergic neurons are also briefly mentioned.

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“…Nevertheless, in recent years when we tried to turn a conversation to a discussion of his scientific accomplishments, he often revealed his modest and unpretentious nature by the unfeigned relish with which he recounted what he liked to call "the fortuities of my life," the sequence of happy accidents without which he believed his life and career might have turned out very differently. So, because his accomplishments have already been summarized in more conventional form so frequently and so well (for example, Cowan, 1981Cowan, , 2001Levi-Montalcini, 1981, Oppenheim andLauder, 2001), we have decided to use this opportunity to share accounts of some of the happy accidents and coincidences in Viktor's life that he so much enjoyed telling us about. Some of these come directly from an abbreviated list of "Fortuities" that he prepared for distribution to selected friends approximately a year ago, others come from various conversations over the years, and still others come from the published record.…”

Section: Introductionmentioning

confidence: 99%