Viktor Hamburger: A prepared, persistent, and deserving mind favored by many “Fortuities”

Kirk, David L.; Allen, Garland E.

doi:10.1002/dvdy.1238

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…From the early pioneering works of Ross G. Harrison and Viktor Hamburger through those of John Saunders and Lewis Wolpert, the past century has revolutionized our understanding of the tetrapod limb development (Oppenheimer 1966;Kirk and Allen 2001;Tickle 2017;Smith 2021). As several recent high-profile reviews have summarized the essentials about the emerging "textbook view" of this process (Tickle 2015;Petit et al 2017;McQueen and Towers 2020;Royle et al 2021), we will only briefly introduce the basic anatomical structure of the tetrapod limbs and, subsequently, the main molecular players involved (see Table 1).…”

Section: Overview Of Tetrapod Limb Developmentmentioning

confidence: 99%

Gene expression changes during the evolution of the tetrapod limb

Varga

2022

BIOLOGIA FUTURA

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Major changes in the vertebrate anatomy have preceded the conquest of land by the members of this taxon, and continuous changes in limb shape and use have occurred during the later radiation of tetrapods. While the main, conserved mechanisms of limb development have been discerned over the past century using a combination of classical embryological and molecular methods, only recent advances made it possible to identify and study the regulatory changes that have contributed to the evolution of the tetrapod appendage. These advances include the expansion of the model repertoire from traditional genetic model species to non-conventional ones, a proliferation of predictive mathematical models that describe gene interactions, an explosion in genomic data and the development of high-throughput methodologies. These revolutionary innovations make it possible to identify specific mutations that are behind specific transitions in limb evolution. Also, as we continue to apply them to more and more extant species, we can expect to gain a fine-grained view of this evolutionary transition that has been so consequential for our species as well.

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Section: Overview Of Tetrapod Limb Developmentmentioning

confidence: 99%

Gene expression changes during the evolution of the tetrapod limb

Varga

2022

BIOLOGIA FUTURA

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“…In 1947, Rita Levi Montalcini joined the laboratory of Viktor Hamburger (Figure 1), one of the most accredited neuroembryologists of the twentieth century (Kirk & Allen III, 2001; Ribatti, 2016). In 1948, Elmer Bueker, a postgraduate student of Hamburger, demonstrated that after implantation of small fragments of malignant small sarcoma 37 and 180 into the hind limb fields of chick embryos, sensory fibers invaded the tumors and the adjacent dorsal root ganglia were markedly enhanced (Bueker, 1948).…”

Section: Introductionmentioning

confidence: 99%

The studies of Rita Levi‐Montalcini on the effects of tumor transplantation on the chorioallantoic membrane

Ribatti

2022

Clinical Anatomy

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In 1986, Rita Levi‐Montalcini and Stanley Cohen were awarded with the Nobel Prize for Physiology and Medicine for the discovery of the nerve growth factor. Among the experimental models used by Levi‐Montalcini in the first part of her studies it was the chick embryo chorioallantoic membrane, currently used in the study of tumor growth and angiogenesis. Levi‐Montalcini grafted fragments of mouse sarcomas on to the chorioallantoic membranes of 4‐ to 6‐day chick embryos and demonstrated that the tumors infiltrated the host blood vessels. Moreover, the ganglia showed hypertrophy, nerve fibers reaching to the implanted tumors. Levi‐Montalcini hypothesized that the effects could have been mediated by a soluble factor, which was later identified as the nerve growth factor.

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“…4 Hamburger, ''Fortuities in My Life,'' Unpublished essay, n.d.: p. 1. See alsoKirk and Allen, 2001. …”

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A Pact with the Embryo: Viktor Hamburger, Holistic and Mechanistic Philosophy in the Development of Neuroembryology, 1927?1955

Allen¹

2004

Journal of the History of Biology

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Viktor Hamburger was a developmental biologist interested in the ontogenesis of hte vertebrate nervous system. A student of Hans Spemann at Freiburg in the 1920s, Hamburger picked up a holistic view of the embryo that precluded him from treating it in a reductionist way; at the same time, he was committed to a materialist and analytical approach that eschewed any form of vitalism or metaphysics. This paper explores how Hamburger walked this thin line between mechanistic reductionism and metaphysical vitalism in light of his work on the factors influencing growth of neurons into limb buds, and the discovery of nerve growth factor, work carried out with Rita Levi-Montalcini and Stanley Cohen.

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Viktor Hamburger: A prepared, persistent, and deserving mind favored by many “Fortuities”

Cited by 3 publications

References 18 publications

Gene expression changes during the evolution of the tetrapod limb

Gene expression changes during the evolution of the tetrapod limb

The studies of Rita Levi‐Montalcini on the effects of tumor transplantation on the chorioallantoic membrane

A Pact with the Embryo: Viktor Hamburger, Holistic and Mechanistic Philosophy in the Development of Neuroembryology, 1927?1955

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