Video-assisted thoracic surgery for pure ground-glass opacities 2 cm or less in diameter

Yamada, Shunsuke; Kohno, Tadasu

doi:10.1016/j.athoracsur.2003.12.040

Cited by 67 publications

(37 citation statements)

References 18 publications

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“…Table 2 summarises the data from nine Japanese reports focused on the surgical treatment of small BACs, currently f2 cm in diameter or less, although two series include larger tumours [13,[55][56][57][58][59][60][61][62]. In most reports, these small BACs represent ,2% of the lung cancer series, and were treated by either lobectomy or sublobar resection.…”

Section: Combined Therapiesmentioning

confidence: 99%

Sublobar resection for lung cancer

Rami–Porta

Tsuboi²

2008

European Respiratory Journal

100

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Sublobar resection for small lung cancers has been debated frequently and is still a controversial issue. The only randomised trial comparing lobectomy with sublobar resections found a significantly higher recurrence rate for the latter, but failed to show significant differences in survival, although survival was better for the lobectomy group. One meta-analysis and several nonrandomised comparisons have confirmed these results. In general, lobectomy and sublobar resections have similar 5-yr survival rates. Local recurrence after wedge resection is higher than after segmentectomy. However, for patients aged .71 yrs, lobectomy and wedge resection are associated with similar survival. For tumours of f2 cm, segmentectomy is equivalent to lobectomy, but survival after segmentectomy is worse if performed for larger tumours. For both segmentectomy and wedge resection, tumour margins should be o1 cm wide to avoid recurrence. For pure bronchioloalveolar carcinoma of f2 cm, diagnosed intraoperatively with certainty, sublobar resection seems equivalent to lobectomy, and because there is no nodal involvement, systematic nodal dissection may not be necessary. In case of doubt, however, lobectomy with systematic nodal dissection will ensure complete resection and adequate staging. More randomised trials are needed to confirm all these issues.

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Section: Combined Therapiesmentioning

confidence: 99%

Sublobar resection for lung cancer

Rami–Porta

Tsuboi²

2008

European Respiratory Journal

100

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“…Multiple studies [1][2][3][4][5][6][7] have shown a 100% 5-year disease-free survival rate, if complete resection is performed for patients with solitary lung adenocarcinoma exhibiting pure lepidic growth (<2-3 cm). Corresponding to adenocarcinoma in situ (AIS) in the International Association for the Study of Lung Cancer/American Thoracic Society/ European Respiratory Society international multidisciplinary classification of lung adenocarcinoma, 8) these tumors are a good indication for sublobar resection.…”

Section: Introductionmentioning

confidence: 99%

Invasiveness and Malignant Potential of Pulmonary Lesions Presenting as Pure Ground-Glass Opacities

Ichinose

Kohno

Fujimori

et al. 2014

Ann Thorac Cardiovasc Surg

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“…1,2 Direct visualization of the pleural space and lung surface offers higher spatial resolution than noninvasive cross sectional imaging modalities such as CT or MRI, and thus micrometastatic disease that is not identified by these modalities may be seen directly in some cases. 3 However, the luminescence of tumors, especially small foci, is often similar to the adjacent lung parenchyma.…”

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confidence: 99%

Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer

Figueiredo

Alencar

Weissleder

et al. 2006

Intl Journal of Cancer

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Improvement in tumor detection using ''smart'' probes in combination with microcatheter fluorescence thoracoscopy was evaluated in a mouse model. These imaging probes increase in fluorescence intensity after protease activation; cathepsin B is a major activator of the probes used in this study. Lewis lung carcinoma cells were orthotopically implanted in the subpleural lung parenchyma. Two activatable near infrared (NIR) probes with different excitation and emission wavelength were administered intravenously to determine whether wavelength would modulate target to background ratio (TBR). Mice were selectively intubated and thoracoscopy performed. A 0.8 mm outer diameter imaging catheter was used to record simultaneous white-light (anatomic) and NIR (protease expression) images. At both wavelength pairs evaluated (680/700 and 750/780 nm excitation/emission), the intrinsic luminosity differences between tumors and normal lung in uninjected animals was low (p > 0.3 and p 5 0.4, respectively and TBR near 1). In mice receiving protease probes IV, tumors were significantly more fluorescent than adjacent lung (p < 0.0005 for 680/700 and p < 0.006 for 750/780) and TBR increased to approximately 9-fold. Confirmatory fluorescence microscopy and immunohistochemistry were similar and revealed that normal lung had very low levels when compared to tumors of cathepsin B and probe fluorescence. In conclusion, protease sensitive imaging probes selective for cathepsin B, imaged with NIR microcatheters, significantly increase the TBR, making small peripheral lung tumors more readily apparent. Such an approach may be a useful adjunct in staging or restaging patients with lung cancer to find minimal disease in the pleural and subpleural space. ' 2005 Wiley-Liss, Inc.

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Video-assisted thoracic surgery for pure ground-glass opacities 2 cm or less in diameter

Cited by 67 publications

References 18 publications

Sublobar resection for lung cancer

Sublobar resection for lung cancer

Invasiveness and Malignant Potential of Pulmonary Lesions Presenting as Pure Ground-Glass Opacities

Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer

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