Invasiveness and Malignant Potential of Pulmonary Lesions Presenting as Pure Ground-Glass Opacities

Ichinose, Junji; Kohno, Tadasu; Fujimori, Sakashi; Harano, Takashi; Suzuki, Souichiro; Fujii, Takeshi

doi:10.5761/atcs.oa.13-00005

Cited by 52 publications

(43 citation statements)

References 23 publications

(22 reference statements)

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“…Two more recent studies that reported on SSNs ≤20 mm diameter are shown in table 10 103 104. One study looked at a CT-detected series and the other resected all lesions.…”

Section: Management Of Ssnsmentioning

confidence: 99%

“…Ichinose et al ,104 again from Japan, looked at 191 resected lesions in 160 patients. They found that the proportion of lesions that were malignant was higher, probably owing to the different selection criteria.…”

Section: Management Of Ssnsmentioning

confidence: 99%

“…None of the pGGNs (n=30) or PSNs (number not given) with solid component ≤10 mm had nodal metastases. Ichinose et al 104 reported that one of 114 pGGNs showed lymph node involvement. A further study of 57 SSNs showed that the proportion of the solid component was predictive of nodal metastases and that there were no metastases in the 15 SSNs where the solid component was ≤25% of the total diameter 98…”

Section: Management Of Ssnsmentioning

confidence: 99%

“…Nomori et al 140 reported 15 pGGNs (10 malignant, 5 benign) from a cohort of 136 nodules; nine malignant nodules were falsely negative on FDG PET, whereas four benign nodules were falsely positive and similarly concluded that FDG PET could not evaluate ground-glass nodules accurately. Ichinose used an SUV cut off point of 0.8 and found that for 64 pGGNs that had PET, the sensitivity was 67% and specificity 89% for detection of invasive lung cancer 104. Smaller retrospective studies have suggested that SSNs with increased FDG uptake may have a potential benign infective/inflammatory aetiology and should therefore be followed-up with CT rather than with more invasive investigations 141 142…”

Section: Further Imaging In Management Of Pulmonary Nodulesmentioning

confidence: 99%

See 3 more Smart Citations

British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE

Callister

Baldwin

Akram

et al. 2015

Thorax

714

724

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“…Two more recent studies that reported on SSNs ≤20 mm diameter are shown in table 10 103 104. One study looked at a CT-detected series and the other resected all lesions.…”

Section: Management Of Ssnsmentioning

confidence: 99%

Section: Management Of Ssnsmentioning

confidence: 99%

Section: Management Of Ssnsmentioning

confidence: 99%

Section: Further Imaging In Management Of Pulmonary Nodulesmentioning

confidence: 99%

See 2 more Smart Citations

British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE

Callister

Baldwin

Akram

et al. 2015

Thorax

714

724

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“…The ratio of invasive adenocarcinomas of pure GGO lesions with changes is significantly higher than those without changes. Monitoring by temporal CT is mandatory even though the invasiveness of pure GGO lesions has been reported to be low (19,20).…”

Section: Discussionmentioning

confidence: 99%

Surgical intervention for ground glass dominant lesions: observation or outright resection?

Fukui

Suzuki

Matsunaga

et al. 2017

Japanese Journal of Clinical Oncology

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Background: The management of ground glass opacity (GGO) on computed tomography (CT) remains controversial. Information of the relationship between clinical behavior and pathological invasiveness of GGO is valuable for management. We conducted this retrospective study to establish differences in the pathological invasiveness between GGO with and without changes. Methods: Among 1762 patients, the following criteria was used: (1) maximum tumor diameter of 3 cm or less, (2) tumor having 50% or more GGO and (3) resection after at least three months of follow up. A change of CT findings was defined as an increase in the diameter or consolidation compared with the initial CT. The relationship between preoperative changes and ratio of invasive adenocarcinoma was investigated. Predictors of GGO growth were also examined. Results: There were 250 patients: pure GGO without changes (G-N group; n = 118), pure GGO with changes (G-C group; n = 35), part-solid GGO without changes (S-N group; n = 78), and partsolid GGO with changes (S-C group; n = 20). The ratio of invasive adenocarcinoma in each group was 0.54, 0.89, 0.8, and 0.90. There was a significant difference between the G-N and G-C group (P < 0.001). However, there was no significant difference between the G-C, S-N and S-C group. Multivariate analysis indicated age was a predictor of preoperative changes (OR = 1.953, P = 0.049). Conclusions:The pathological results of part-solid GGO with changes were not different from those without changes. Therefore surgery can be deferred until those lesions demonstrate changes. The pathological results of pure GGO with changes were equivalent to those of partsolid GGO. Therefore, even for pure GGO, follow up is necessary especially in elderly patients.

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The Roles of Cellular Nanomechanics in Cancer

Yallapu

Katti

et al. 2014

Medicinal Research Reviews

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The biomechanical properties of cells and tissues may be instrumental in increasing our understanding of cellular behavior and cellular manifestations of diseases such as cancer. Nanomechanical properties can offer clinical translation of therapies beyond what are currently employed. Nanomechanical properties, often measured by nanoindentation methods using atomic force microscopy, may identify morphological variations, cellular binding forces, and surface adhesion behaviors that efficiently differentiate normal cells and cancer cells. The aim of this review is to examine current research involving the general use of atomic force microscopy/nanoindentation in measuring cellular nanomechanics; various factors and instrumental conditions that influence the nanomechanical properties of cells; and implementation of nanoindentation methods to distinguish cancer cells from normal cells or tissues. Applying these fundamental nanomechanical properties to current discoveries in clinical treatment may result in greater efficiency in diagnosis, treatment, and prevention of cancer, which ultimately can change the lives of patients.

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Invasiveness and Malignant Potential of Pulmonary Lesions Presenting as Pure Ground-Glass Opacities

Cited by 52 publications

References 23 publications

British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE

British Thoracic Society guidelines for the investigation and management of pulmonary nodules: accredited by NICE

Surgical intervention for ground glass dominant lesions: observation or outright resection?

The Roles of Cellular Nanomechanics in Cancer

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