Vicarious substitution of hydrogen with carbanions of dithioacetals

Hydroxylation and Amination of Azulenes by Vicarious Nucleophilic Substitution of Hydrogen

“…banions containing sulfur-based leaving groups are efficient reagents for the VNS cyanomethylation of nitroarenes. [1,4,14] The reported results indicate that VNS is a versatile tool for the introduction of a variety of oxygen, nitrogen, sulfur On the other hand we have found that 4-aminotriazole, proposed by Katritzky for the VNS amination of nitroar-and halogen substituents directly into azulene or by further conversion of hydroxyazulenes. enes, [11a] is an efficient aminating agent of azulenes when [18] and 1g by chlorination of azulene with Nchlorosuccinimide.…”

Difluoromethylation of some C–H acids with chlorodifluoromethane under conditions of phase transfer catalysis (PTC)

“…Column chromatography was performed on Merck Kieselgel 60 (230-400 mesh) with hexane and ethyl acetate mixtures (gradient) as eluents. Chlorodifluoromethane, nitrile 1a, malonates 1h-k and 9-methylsulfanylfluorene (1o) were commercial, while nitriles 1b [35], 1c [36], 1d [37], 1e [38], 1f [39], 1g [40], (phenyl)ethylcyanoacetate (1l) [41] and desoxybenzoines 1m,n [42] were prepared by literature procedures.…”

Syntheses of perdeuterated indoles and derivatives as probes for the biosyntheses of crucifer phytoalexins

“…12 After 60 min, the reaction mixture was poured into ice-cold HCl (25.0 ml, 1 M), was diluted with H 2 O (10.0 ml), and was extracted with CHCl 3 (50.0 ml  3). The combined organic extract was washed with H 2 O (70.0 ml), was dried over Na 2 SO 4 …”