Vibrography: First Experimental Results in Swine Brains

Scholz, Martin; Fricke, B.; Mönnings, Peter; Brendel, Bernhard; Schmieder, Kirsten; Siebers, S.; Düring, Monika von; Ermert, H.; Härders, A.

doi:10.1055/s-2004-818450

Cited by 4 publications

(3 citation statements)

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“…13,14 The work presented here was performed before publication of these papers. The first group 13,17 used a previously described technique called vibrography utilizing a phase root-seeking algorithm as opposed to the cross-correlation technique 18 and low-frequency vibrations rather than freehand static compression. They also noted the stiffness heterogeneity between different tumours compared with brain but did not have surgical comparisons.…”

Section: Discussionmentioning

confidence: 99%

Preliminary investigation into the use of ultrasound elastography during brain tumour resection

2012

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Introduction Differentiation of brain tumours from normal brain, during surgical resection is, in part, based on their differing mechanical properties. Brain tumours have variable stiffness characteristics. Surgical evaluations on stiffness are, at best, subjective. Ultrasound elastography is a non-invasive method for imaging mechanical properties of tissues such as stiffness at depth. It is hypothesized that this technique may assist in differentiating tumour from the brain in an intraoperative setting. Methods This study evaluated the feasibility of the intraoperative use of ultrasound elastography during brain tumour resection. A total of 24 patients were recruited for the study. Surgical findings on tumour stiffness were compared with the elastogram findings. Furthermore, visibility of the brain-tumour interface on ultrasound echography compared with ultrasound elastography was analysed. Results Ultrasound elastography was found to have a sensitivity of 100% and specificity of 75% at detecting that tumour had a different stiffness to the brain when compared with surgical findings. The technique was also found to have a 100% sensitivity and specificity at the detection of intratumoral stiffness heterogeneity compared with surgical findings. The presence of fluid-filled cysts limited the quality of the elastograms. Ultrasound elastography did not detect the brain-tumour interface as accurately as conventional echography. Conclusion These findings suggest that ultrasound elastography in combination with conventional B-mode ultrasound may be a useful adjunct to differentiate tumour from the brain.

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Section: Discussionmentioning

confidence: 99%

Preliminary investigation into the use of ultrasound elastography during brain tumour resection

2012

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“…This technique has been applied experimentally to biological material in vitro to characterize intravascular arterial plaques, 13 thermal lesions in postmortem ovine kidney, 14 or agarose depots in brain tissue of swine. 10 In more recent studies, the clinical application of elastography to detect small soft tissue tumors (eg, prostate and breast tumors) 15,16 has been evaluated by applying compression to the tissue manually.…”

Section: Discussionmentioning

confidence: 99%

Vibrography During Tumor Neurosurgery

Scholz

Noack

Pechlivanis

et al. 2005

Journal of Ultrasound in Medicine

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“…After previous animal experiments [1] and approval by the Ethics Commission of Ruhr University Bochum, this study was started. The following were considered exclusion criteria: tumours in eloquent areas, emergency cases with brain swelling, and brain tumours in children.…”

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confidence: 99%