Vibrography During Tumor Neurosurgery

Scholz, Martin; Noack, V.; Pechlivanis, Ioannis; Engelhardt, Martin; Fricke, B.; Linstedt, Ulf; Brendel, Bernhard; Schmieder, Kirsten; Ermert, H.; Härders, A.

doi:10.7863/jum.2005.24.7.985

Cited by 44 publications

(34 citation statements)

References 26 publications

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“…In this Letter, we report for the first time to our knowledge the recovery of the elastic property (though qualitatively) using photoacoustic imaging. This imaging of elastic property is promising for preclinical study and clinical applications of diagnosis and therapeutic treatment of diseases that are characterized by changes in the elastic property of tissues such as brain tumors [5], breast and prostate cancers [6], and Alzheimers [7] and subsequently, this study enhances the horizon of potential clinical applications of PA imaging to diagnosis and therapeutic treatments. On the other hand, the existing imaging modalities (ultrasound and MRI) for recovery of elastic property fail to give physiological information while PA imaging, as a single imaging unit, can provide multiple functional and structural parameters that are of great clinical interest and value.…”

mentioning

confidence: 86%

Elastic property attributes to photoacoustic signals: an experimental phantom study

Singh

Jiang

2014

Opt. Lett.

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We report an experimental study that shows the attribution of the elastic property of light absorbing targets to the generation of ultrasound signals induced due to the photoacoustic effect. We investigated the variation in strength of the detected photoacoustic signals for various targets embedded in a background phantom with: (1) different elastic coefficients (94-346 kPa) and (2) various sizes (0.25-1.5 mm²). The results show that photoacoustic signals increase with an increase in elastic coefficient (i.e., showing to contrast in elastic property) while it is independent of variation in target sizes. Quantitative (analysis) study, and 2D and 3D reconstructed images are also presented. This study demonstrates the feasibility of imaging elastic property using photoacoustic technique.

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mentioning

confidence: 86%

Elastic property attributes to photoacoustic signals: an experimental phantom study

Singh

Jiang

2014

Opt. Lett.

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“…Although many of these studies have shown that tumors are stiffer than normal brain (Xu et al, 2007;Scholz et al, 2007Scholz et al, , 2005Chauvet et al, 2015), some have shown the opposite (Reiss- Zimmermann et al, 2015;Streitberger et al, 2014), and determination of stiffness differences between tumor grades has been inconclusive using this technique. Consistent with observations of stiffening of brain tumors, increased diffusion of water within a tumor, as measured by magnetic resonance imaging (MRI), is prognostic of poor outcome and is correlated with increased expression of ECM genes whose products are expected to stiffen a tissue (Pope et al, 2012(Pope et al, , 2009.…”

Section: Mechanical Properties Of Brain Tumor Subtypesmentioning

confidence: 99%

Tissue mechanics regulate brain development, homeostasis and disease

Barnes

Przybyla

Weaver

2017

Journal of Cell Science

260

245

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All cells sense and integrate mechanical and biochemical cues from their environment to orchestrate organismal development and maintain tissue homeostasis. Mechanotransduction is the evolutionarily conserved process whereby mechanical force is translated into biochemical signals that can influence cell differentiation, survival, proliferation and migration to change tissue behavior. Not surprisingly, disease develops if these mechanical cues are abnormal or are misinterpreted by the cells – for example, when interstitial pressure or compression force aberrantly increases, or the extracellular matrix (ECM) abnormally stiffens. Disease might also develop if the ability of cells to regulate their contractility becomes corrupted. Consistently, disease states, such as cardiovascular disease, fibrosis and cancer, are characterized by dramatic changes in cell and tissue mechanics, and dysregulation of forces at the cell and tissue level can activate mechanosignaling to compromise tissue integrity and function, and promote disease progression. In this Commentary, we discuss the impact of cell and tissue mechanics on tissue homeostasis and disease, focusing on their role in brain development, homeostasis and neural degeneration, as well as in brain cancer.

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“…The biomechanical properties of the brain have been the subject of many recent studies related to hydrocephalus (1)(2)(3), traumatic brain injury (4)(5)(6), and the evaluation of stroke or intraoperative evaluation (7,8). Most biomechanical tests were carried out by invasive indentation experiments (9,10) to specifically measure the elasticity of cortical brain tissue.…”

Section: Introductionmentioning

confidence: 99%

Non‐invasive measurement of brain viscoelasticity using magnetic resonance elastography

et al. 2007

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The purpose of this work was to develop magnetic resonance elastography (MRE) for the fast and reproducible measurement of spatially averaged viscoelastic constants of living human brain. The technique was based on a phase-sensitive echo planar imaging acquisition. Motion encoding was orthogonal to the image plane and synchronized to intracranial shear vibrations at driving frequencies of 25 and 50 Hz induced by a head-rocker actuator. Ten time-resolved phase-difference wave images were recorded within 60 s and analyzed for shear stiffness and shear viscosity. Six healthy volunteers (six men; mean age 34.5 years; age range 25-44 years) underwent 23-39 follow-up MRE studies over a period of 6 months. Interindividual mean +/- SD shear moduli and shear viscosities were found to be 1.17 +/- 0.03 kPa and 3.1 +/- 0.4 Pas for 25 Hz and 1.56 +/- 0.07 kPa and 3.4 +/- 0.2 Pas for 50 Hz, respectively (P < or = 0.01). The intraindividual range of shear modulus data was 1.01-1.31 kPa (25 Hz) and 1.33-1.77 kPa (50 Hz). The observed modulus dispersion indicates a limited applicability of Voigt's model to explain viscoelastic behavior of brain parenchyma within the applied frequency range. The narrow distribution of data within small confidence intervals demonstrates excellent reproducibility of the experimental protocol. The results are necessary as reference data for future comparisons between healthy and pathological human brain viscoelastic data.

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Vibrography During Tumor Neurosurgery

Abstract: These findings indicate that vibrography is a feasible imaging method for brain tumor surgery and may have numerous potential applications in neurosurgery if further improvements are made.

Cited by 44 publications

References 26 publications

Elastic property attributes to photoacoustic signals: an experimental phantom study

Elastic property attributes to photoacoustic signals: an experimental phantom study

Tissue mechanics regulate brain development, homeostasis and disease

Non‐invasive measurement of brain viscoelasticity using magnetic resonance elastography

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