Vibrational spectra of calcium, strontium and barium valproates. Self-assembly of valproate nanostrands in aqueous solution and in the solid state

Naumov, Panče; Petruevski, Gjorgji; Jovanovski, Gligor

doi:10.1039/c000488j

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Thus, the above-mentioned effect is unlikely. Semiquantitative correlations based on the frequency differences between the carbonyl stretching vibration of the carboxylate group have been frequently employed to obtain information on the coordination in metal–organic complexes of organic acids . The intensity of SrRAN functional groups in the FTIR spectra of the SrRAN-nHAp is very low due to the relatively low concentration of the SrRAN (Figure B,B’).…”

Section: Resultsmentioning

confidence: 99%

“…To obtain the calibration curve, SrRAN was dissolved in DMEM, homogenized in an ultrasonic bath, and mixed for 40 min to acquire the stock solution. Next, the stock solution was diluted to five different concentrations (10,50,100,200, 250 μg/mL), which were measured using a two-beam ultraviolet− visible light spectrophotometer (UV/vis, Evolution 300, Thermo Scientific Waltham, MA, United States) at λ = 318 nm to plot the calibration curve. The SrRAN (anion ranelate) concentrations in samples were calculated using the linear calibration curve (correlation coefficient R 2 = 0.99997).…”

Section: ■ Introductionmentioning

confidence: 99%

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A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

Stipniece,

Ramata-Stunda,

Vecstaudza

et al. 2023

ACS Appl. Bio Mater.

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Synthetic hydroxyapatite nanoparticles (nHAp) possess compositional and structural similarities to those of bone minerals and play a key role in bone regenerative medicine. Functionalization of calcium phosphate biomaterials with Sr, i . e ., bone extracellular matrix trace element, has been proven to be an effective biomaterial-based strategy for promoting osteogenesis in vitro and in vivo . Functionalizing nHAp with Sr 2+ ions or strontium ranelate (SrRAN) can provide favorable bone tissue regeneration by locally delivering bioactive molecules to the bone defect microenvironment. Moreover, administering an antiosteoporotic drug, SrRAN, directly into site-specific bone defects could significantly reduce the necessary drug dosage and the risk of possible side effects. Our study evaluated the impact of the Sr source (Sr 2+ ions and SrRAN) used to functionalize nHAp by wet precipitation on its in vitro cellular activities. The systematic comparison of physicochemical properties, in vitro Sr 2+ and Ca 2+ ion release, and their effect on in vitro cellular activities of the developed Sr-functionalized nHAp was performed. The ion release tests in TRIS-HCl demonstrated a 21-day slow and continuous release of the Sr 2+ and Ca 2+ ions from both Sr-substituted nHAp and SrRAN-loaded HAp. Also, SrRAN and Sr 2+ ion release kinetics were evaluated in DMEM to understand their correlation with in vitro cellular effects in the same time frame. Relatively low concentration (up to 2 wt %) of Sr in the nHAp led to an increase in the alkaline phosphatase activity in preosteoblasts and expression of collagen I and osteocalcin in osteoblasts, demonstrating their ability to boost bone formation.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

Stipniece,

Ramata-Stunda,

Vecstaudza

et al. 2023

ACS Appl. Bio Mater.

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“…A characteristic signal can be observed at the Raman shift position of approximately 1445 cm −1 in spectra of VPA (line (b)). This peak is caused by the bending mode of CH 2 and CH 3 groups of VPA [10]. Some strong peaks are shown at 407 cm −1 , 544 cm −1 , and 1344 cm −1 in spectrum of glucose (line (c)).…”

Section: Methodsmentioning

confidence: 93%

Paper-based Raman spectroscopy for on-site therapeutic drug monitoring

Yokoyama

Nishimura

Yamada

et al. 2014

2014 IEEE Healthcare Innovation Conference (HIC)

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This study proposes Raman spectroscopy of tear fluid with paper substrates for on-site therapeutic drug monitoring(TDM). In this method, the paper substrates are used for tear sample collection and measurement. The use of paper offers a minimally-invasive, simple, and inexpensive method for therapeutic drug monitoring. To demonstrate the usability of the paper substrates for this purpose, we measured Raman spectra of samples containing therapeutic drug and glucose with a filter paper. Experimental results show the ability to detect Raman signals from the samples absorbed on the paper substrate.

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“…This advantages provide a rapid and simple method for monitoring the concentration of drugs, and would contribute to application in the medical field. There are multiple methods which can enhance the sensitivity of Raman spectroscopy such as surface-enhanced Raman scattering (SERS) [8], resonance Raman scattering [9], and crystallization of the sample [11]. Using these techniques, we will improve the sensitivity and save measuring time, and aim for application to the monitoring of other therapeutic drugs and practical use in the medical field.…”

Section: Discussionmentioning

confidence: 99%

“…The strong peaks were observed around 2904 cm −1 and 1452 cm −1 . These peaks come from the stretching vibration of C-H and the bending mode of CH 2 and CH 3 groups, respectively [9]. The peaks derived from the skeleton C-C vibrations (1330-1300 cm −1 ) and the stretching vibrations of C-O (∼1110 cm −1 ) were also observed.…”

Section: B Instrumentsmentioning

confidence: 95%

Proposal of estimation method for drug concentration in blood by Raman spectroscopy of tear fluids

Yokoyama

Nishimura

Yamada

et al. 2013

The 6th 2013 Biomedical Engineering International Conference

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Drug concentrations in blood are good indexes for drug thearpy. This study proposed an approach based on Raman spectroscopy of tears for a rapid and minimally invasive monitoring of the concentration. Tear fluid reflects the drug concentration in blood and its collection can be performed easily and noninvasively in comparison to blood drawing. Raman spectroscopy is a rapid and sensitive analytical technique, which is suitable for measurement of small volume samples such as human tears. As a first step, we measured the Raman spectra of 2 μL solutions of valproic acid to reveal the sensitivity toward a small amount of drug in tears. The measurement was performed with hydrophobic silicon substrates to concentrate fluid samples. The experimental result demonstrates that the method has sufficient sensitivity to monitor concentration of valproic acid in blood.

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Vibrational spectra of calcium, strontium and barium valproates. Self-assembly of valproate nanostrands in aqueous solution and in the solid state

Cited by 7 publications

References 16 publications

A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

A Comparative Study on Physicochemical Properties and In Vitro Biocompatibility of Sr-Substituted and Sr Ranelate-Loaded Hydroxyapatite Nanoparticles

Paper-based Raman spectroscopy for on-site therapeutic drug monitoring

Proposal of estimation method for drug concentration in blood by Raman spectroscopy of tear fluids

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