Vibration sonoelastography and the detectability of lesions

Parker, Kevin J.; Fu, Dongshan; Graceswki, Sheryl M.; Yeung, Fai; Levinson, Stephen F.

doi:10.1016/s0301-5629(98)00123-9

Cited by 120 publications

(70 citation statements)

References 16 publications

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“…The capability of sonoelastography to find cancer depends on the size and elastic contrast of the tumor in comparison with the normal surrounding tissue [30]. In our experiments, the average diameter was less than 10 mm and the expected elastic contrast was less than 3 (from Section 2).…”

Section: Discussionmentioning

confidence: 67%

“…Due to a relationship between particle vibrational response and received Doppler spectral variance [29], the amplitude of low frequency shear waves propagating in tissue can be visualized in real-time using sonoelastography to detect regions of abnormal stiffness [30]. In a more recent sonoelastographic development, it was shown that interfering shear waves could produce slowly propagating interference patterns with an apparent velocity much less than (but proportional to) the underlying true shear velocity [31].…”

Section: Introductionmentioning

confidence: 99%

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Tissue elasticity properties as biomarkers for prostate cancer

Hoyt

Castaneda

Zhang

et al. 2008

CBM

Self Cite

267

182

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In this paper we evaluate tissue elasticity as a longstanding but qualitative biomarker for prostate cancer and sonoelastography as an emerging imaging tool for providing qualitative and quantitative measurements of prostate tissue stiffness. A Kelvin-Voigt Fractional Derivative (KVFD) viscoelastic model was used to characterize mechanical stress relaxation data measured from human prostate tissue samples. Mechanical testing results revealed that the viscosity parameter for cancerous prostate tissue is greater than that derived from normal tissue by a factor of approximately 2.4. It was also determined that a significant difference exists between normal and cancerous prostate tissue stiffness (p < 0.01) yielding an average elastic contrast that increases from 2.1 at 0.1 Hz to 2.5 at 150 Hz. Qualitative sonoelastographic results show promise for cancer detection in prostate and may prove to be an effective adjunct imaging technique for biopsy guidance. Elasticity images obtained with quantitative sonoelastography agree with mechanical testing and histological results. Overall, results indicate tissue elasticity is a promising biomarker for prostate cancer.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Tissue elasticity properties as biomarkers for prostate cancer

Hoyt

Castaneda

Zhang

et al. 2008

CBM

Self Cite

267

182

View full text Add to dashboard Cite

show abstract

“…Parker et al [11] used a normal point source to verify FEM simulation results of displacement patterns, Catheline et al [12] measured the diffraction field of a point source using transient elastography. Yamakoshi et al [8] applied vibration to a tissue phantom using a perpendicularly vibrating rectangular plate, and…”

Section: Techniquesmentioning

confidence: 99%

Comparison of Vibrational Displacements Generated by Different Types of Surface Source in a Soft Tissue

Park¹,

Kwon²,

Jeong³

2012

Journal of the Korean Society for Nondestructive Testing

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The propagation characteristics of a mechanical wave in human soft tissue depend on its elastic properties. Investigation of these propagation characteristics is of paramount importance because it may enable us to diagnose cancer or tumor from the vibration response of the tissue. This paper investigates and compares displacement patterns generated in soft tissue due to several forms of low-frequency vibration sources placed on a surface. Among vibration sources considered are a normal load, tangential load, and antiplane shear load. We derive analytical expressions for displacements in viscoelastic single layers, and calculate displacement patterns in half space and infinite plate type tissue. Also, we simulate the vibration response of a finite-sized tissue using finite element method. The effects of the type of stress, the size and frequency of vibration sources, and medium boundaries on displacement patterns are discussed.

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“…A hard inhomogene- ity will produce a disturbance in the vibration response, forming the basis of detection of a tumour, even if it is isoechoic on grey scale ultrasound. 79 Sarvazyan et al 80 described the theoretical and technical aspects of shear wave elasticity imaging. They conclude that many issues including safety must be considered before the method can be used in clinical studies, but it has the potential of a valuable diagnostic tool.…”

Section: Future Prospectives Of Transrectal Ultrasonographymentioning

confidence: 99%

Transrectal ultrasound imaging of the prostate: review and perspectives of recent developments

Sedelaar

Rosette

Beerlage

et al. 1999

Prostate Cancer Prostatic Dis

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We present a critical review of the recent literature and discuss the development and prospective view of the evaluations of transrectal ultrasound with regard to prostate malignancy. We illustrate this with personal experiences. Material and Methods: Based on a critical evaluation of clinical data we address the apparent shortcoming of greyscale transrectal ultrasonography in the assessment of prostate cancer. New developments and future possibilities are also discussed.Evaluation of the value of greyscale transrectal ultrasonography in the diagnosis of prostate cancer indicates a limited role, because of the non-uniform appearance of prostate cancer on the ultrasound images. Ameliorating of transrectal ultrasound, like the use of contrast ultrasonography, could improve the detection of prostate cancer.Although the use of greyscale transrectal ultrasonography lacks sensitivity and speci®city for the diagnosis of prostate cancer, its use in volume measurement of the prostate and biopsy guidance is unquestionable. The ®rst results of the application of contrast ultrasonography are promising, both in detection of prostate cancer as in treatment follow up. Other developments like improvement of transducer and computer technology could make the use of ultrasound more versatile. However, future research will indicate whether all these improvements will lead to clinical applications.

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Vibration sonoelastography and the detectability of lesions

Cited by 120 publications

References 16 publications

Tissue elasticity properties as biomarkers for prostate cancer

Tissue elasticity properties as biomarkers for prostate cancer

Comparison of Vibrational Displacements Generated by Different Types of Surface Source in a Soft Tissue

Transrectal ultrasound imaging of the prostate: review and perspectives of recent developments

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