In this article, experimental studies for the preparation, characterization and nanomechanical membrane (NMM) application of Graphene-based nanomechanical mass and acoustic hybrid-sensor are carried out. Small-scale Graphene many-layer membranes were prepared by facile and low-cost mechanical exfoliation method and transferred onto the drilled Silicon dioxide frame-substrates by the developed set-ups. Characterization and tests were performed and interpreted by the morphological, spectroscopical and nanomechanical characterizations with the equipment and items like optical, digital, atomic force and scanning electron microscopes, Raman spectroscope, quantum dots, acoustic signal source and amplifier, data-logger, sound pressure level meter and laser Doppler vibrometer. Graphene-based NMM sensor chips with varying acoustic pressure levels and mass-loadings are tested, experimental challenges and sensor development solutions are discussed. Existing application examples are examined and evaluations are made about the current challenges and future of the NMM sensors.