Viable Meniscal Transplantation

Verdonk, René; Daele, Peter Van; Claus, Benedikt B.; Abbeele, K Van den; Desmet, Paul; Verbruggen, Gust; Veys, Eric; Claessens, H

doi:10.1007/978-3-7091-6885-1_30

Cited by 23 publications

(32 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most medial meniscal margin contains a distinctly lower percentage of original glucosaminoglycans, compared to what can be found in the fragments obtained from other sites of the meniscus (41). These findings are also consistent with Tanaka et al's.…”

Section: Metabolism and Topographysupporting

confidence: 93%

Meniscal substitutes – animal experience

Kohn

Verdonk

Aagaard

et al. 1999

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

Animal studies have shown that meniscus allografts and tendon autografts generally heal to the capsule, are revascularjzed and repopulated with host cells. In animals, neither meniscal allografts nor tendon or fat autografts gain the properties of a normal meniscus. Meniscus allografts and tendon autografts are promising as both seem to offer some protection to the cartilage of the tibial plateau. There is no evidence that meniscal transplantation can prevent cartilage degenerative changes, and the longterm effect of meniscal transplantation on articular cartilage remains unknown. Whether cellular repopulation of the meniscal allograft is sufficient to restore its biomechanical properties is unknown. Collagen scaffolds and tissue engineered grafts are still under investigation, showing promising results especially for the former. Viable meniscal allografts should be implanted within 1 to 2 weeks after harvesting, as the production of proteoglycans decreases after 2 weeks. Different types of menlscal substitutes (D. Kohn, R. Seil, M. Dienst)The interest in meniscal replacement emerged in the 1980s. It has been investigated in several animal species: dogs (3, 4, 6, ll, 25, 38), sheep (7, 20, 22, 26), goats (10, 15, 16) and rabbits (19, 30, 36, 42). Different types of tissue, prostheses (30, 37), scaffolds (31, 32,35), and recently tissue engineered grafts (8,9, 13, 14) have been tested. During the first 10 years most groups concentrated on different types of allografts. Meniscus allograftsThere are numerous experiments in which animals were treated with meniscus allografts (3, 5, 6, 16, 17, 29,36). The results have been dependent on the tissue conservation methods: fresh tissue, cryopreserved, fresh frozen, lyophilized (freeze dried) and glutaraldehyde preserved allografts. Our own experiments (26) with sheep were performed with either lyophilized or deep frozen menisci. They showed that both types of meniscus allografts healed to the capsule and were not rejected by the recipient animal. The transplanted menisci were biomechanidy inferior in comparison to the original tissue. Lyophilized grafts revascularized completely, whereas in deep frozen specimens revascularization only happened at the periphery. Usually, the revascularization process and cellular repopulation had two different origins: the synovial 0. Kohn', R. Verdonk2, H. Aagad, R. Sell1, M. Diienstl tissue on the surface and the central part of the meniscus and the capsular tissue at the meniscus periphery (36).In summary, these animal studies showed that meniscus allografts generally healed to the capsule, revascularized and repopulated with host cells (23). Despite these findings, it remains unclear how long the graft will retain its material properties after transplantation, or whether it will ever take over the func

show abstract

Section: Metabolism and Topographysupporting

confidence: 93%

Meniscal substitutes – animal experience

Kohn

Verdonk

Aagaard

et al. 1999

Scandinavian Med Sci Sports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Access to the knee joint was achieved by a lateral or medial parapatellar arthrotomy. The insertion of the lateral collateral ligament and popliteus tendon or the medial collateral ligament was detached with an osteotomy on the femoral side 15 . The osteotomy fragment was later restored by screw fixation or stapling.…”

Section: Surgical Techniquementioning

confidence: 99%

“…Instead, the anterior and posterior horns of the transplanted meniscus were sutured to the remnant native horns on the tibia. This procedure has been described in detail elsewhere 15 . Postoperative rehabilitation consisted of three weeks of non-weight-bearing with mobilization of the knee, within pain limits, with limitation of flexion to 60°.…”

Section: Surgical Techniquementioning

confidence: 99%

“…Therefore, it is an indicator of overall knee function 17 . This rating system has been used to determine knee function in previous reviews of the results of meniscal allografting procedures and of fresh osteochondral allograft procedures in combination with meniscal allografting 15,18,19 . Since meniscal allografting specifically relieves pain and improves function, the pain score and functional score of the modified HSS system were used for the evaluation of the clinical outcome and for the survival analysis [4][5][6][7] .…”

Section: Clinical Evaluation Of the Knee Jointmentioning

confidence: 99%

See 1 more Smart Citation

Transplantation of Viable Meniscal Allograft

Verdonk

Demurie

Almqvist

et al. 2005

The Journal of Bone & Joint Surgery

270

View full text Add to dashboard Cite

“…25 However, as yet no randomized prospective trials have been performed comparing meniscal transplantation with conservative treatment of post-meniscectomy pain, and there is a time dependant decrease in the quality of outcomes after 3 years. 26 Studies generally contain heterogeneous groups of patients undergoing a variety of additional procedures (ACL/HTO) and grafts processed in a variety of ways. In the United Kingdom graft availability and cost remain a problem.…”

Section: Meniscal Transplantationmentioning

confidence: 99%